Reinforcement of transcriptional silencing by a positive feedback between DNA methylation and non-coding transcription

Autor: M Hafiz Rothi, Andrzej T. Wierzbicki, Masayuki Tsuzuki, Shriya Sethuraman

Publikováno v: Nucleic Acids Research

Non-coding transcription is an important determinant of heterochromatin formation. In Arabidopsis thaliana a specialized RNA polymerase V (Pol V) transcribes pervasively and produces long non-coding RNAs. These transcripts work with small interfering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10afcc7793cfb50e1379ad544e54c911
https://doi.org/10.1093/nar/gkab746

Long non-coding RNA produced by RNA polymerase V determines boundaries of heterochromatin

Autor: Gudrun Böhmdorfer, Shriya Sethuraman, M Jordan Rowley, Michal Krzyszton, M Hafiz Rothi, Lilia Bouzit, Andrzej T Wierzbicki

Publikováno v: eLife, Vol 5 (2016)

RNA-mediated transcriptional gene silencing is a conserved process where small RNAs target transposons and other sequences for repression by establishing chromatin modifications. A central element of this process are long non-coding RNAs (lncRNA), wh

Externí odkaz: https://doaj.org/article/2fd2ef24e3fb48bfa1c98540afe2f95f

DNA methylation directs nucleosome positioning in RNA-mediated transcriptional silencing

Autor: Andrzej T. Wierzbicki, Jakub Dolata, Alan P. Boyle, Shriya Sethuraman, M Hafiz Rothi

Repressive chromatin modifications are instrumental in regulation of gene expression and transposon silencing. In Arabidopsis thaliana, transcriptional silencing is performed by the RNA-directed DNA methylation (RdDM) pathway. In this process, two sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::689e68d5ad3bf8971d80f111d478ef85
https://doi.org/10.1101/2020.10.29.359794

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The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.

Autor: Hafiz Rothi M; Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Sarkar GC; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Haddad JA; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Mitchell W; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA., Ying K; Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Pohl N; Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Sotomayor-Mena RG; Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Natale J; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Dellacono S; Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA., Gladyshev VN; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston MA 02115, USA., Lieberman Greer E; Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston MA, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 15. Date of Electronic Publication: 2024 May 15.