MGMT methylation assessment in glioblastoma: MS-MLPA versus human methylation 450K beadchip array and immunohistochemistry

Autor: Kalthoum Tlili, N. Karmeni, Nadia Mama, Ali Saad, Mohamed Tahar Yacoubi, Saoussen Trabelsi, H. Krifa, M. Mokni, M. Haddaji Mastouri, Marwa Chourabi, Mohamed Ladib, D. H’mida Ben Brahim

Publikováno v: Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 18(4)

The MGMT gene encodes a DNA repair enzyme that counteracts with chemotherapy efficiency, specifically with alkylating agents such as temozolomide (TMZ). It is well established that MGMT methylation should be screened as a predictive marker for TMZ in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7368e99052d16a3b3168863a2936fe8d
https://pubmed.ncbi.nlm.nih.gov/26289551

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Modulation at age of onset in tunisian huntington disease patients: implication of new modifier genes.

Autor: Hmida-Ben Brahim D; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Chourabi M; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Ben Amor S; Department of Neurology, Sahloul Hospital, Sahloul Road, 4054 Sousse, Tunisia., Harrabi I; Department of Epidemiology and Medical Statistics, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Trabelsi S; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Haddaji-Mastouri M; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Gribaa M; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Sassi S; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Gahbiche FE; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Lamouchi T; Department of Neurology, Sahloul Hospital, Sahloul Road, 4054 Sousse, Tunisia., Mougou-Zereli S; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia., Ben Ammou S; Department of Neurology, Sahloul Hospital, Sahloul Road, 4054 Sousse, Tunisia., Saad A; Department of Cytogenetics and Reproductive Biology, Farhat HACHED Hospital, Ibn El Jazzar Road, 4000 Sousse, Tunisia.

Publikováno v: Genetics research international [Genet Res Int] 2014; Vol. 2014, pp. 210418. Date of Electronic Publication: 2014 Sep 01.