Výsledky vyhledávání - "M. H. Stickland"

RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response

Autor: Barry I. Hudson, Loredana G. Bucciarelli, Joanita Monteiro, S Chitnis, Marion A. Hofmann, David M. Stern, Bernhard Moser, Silviu Itescu, Steven Drury, M. H. Stickland, G Moxley, M R Gleason, Evanthia Lalla, Peter K. Gregersen, Yi-Fan Lu, Ann Marie Schmidt, Peter J. Grant, Wu Qu

Publikováno v: Genes & Immunity. 3:123-135

The receptor for advanced glycation end products (RAGE) and its proinflammatory S100/calgranulin ligands are enriched in joints of subjects with rheumatoid arthritis (RA) and amplify the immune/inflammatory response. In a model of inflammatory arthri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05af2e20fff3964db67fc2a43fa1f228
https://doi.org/10.1038/sj.gene.6363861

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Characterization of Allelic and Nucleotide Variation Between the RAGE Gene on Chromosome 6 and a Homologous Pseudogene Sequence to Its 5′ Regulatory Region on Chromosome 3

Autor: Peter J. Grant, M. H. Stickland, T. Simon Futers, Barry I. Hudson

Publikováno v: Diabetes. 50:2646-2651

Activation of the receptor for advanced glycation end products (RAGE) appears to be a key mechanism in the pathogenesis of diabetic vascular disease, making RAGE a candidate gene for investigation. RAGE is located in the major histocompatibility comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3971b5f4f17019e194c453005aef15b8
https://doi.org/10.2337/diabetes.50.12.2646

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Association of a Common Polymorphism in the Factor XIII Gene with Myocardial Infarction

Autor: Hanna K. A. Mikkola, Nicholas Ossei-Gerning, Peter J. Grant, Hans P. Kohler, M. H. Stickland, Angela M. Carter

Publikováno v: Thrombosis and Haemostasis. 79:8-13

SummaryFactor XIII when activated by thrombin, crosslinks fibrin, however its role in thrombotic disorders is unknown. A common point mutation (G T) in exon 2 of the A-subunit gene which codes for an amino acid change three amino acids from the throm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec03eca78acec1821362a35bb9fe29cb
https://doi.org/10.1055/s-0037-1614250

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Levels of Activated FXII in Survivors of Myocardial Infarction – Association with Circulating Risk Factors and Extent of Coronary Artery Disease

Autor: M. H. Stickland, Hans P. Kohler, Angela M. Carter, Peter J. Grant

Publikováno v: Thrombosis and Haemostasis. 79:14-18

SummaryLittle data is available regarding the activated form of factor XIIa (FXIIa) in survivors of myocardial infarction. 292 Caucasian patients characterised for extent of coronary atheroma by angiography and for a past history of myocardial infarc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9223a98fae0e77b5cbada83dded02b5
https://doi.org/10.1055/s-0037-1614210

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PAI-1 Concentrations in First-degree Relatives of Patients with Non-insulin-dependent Diabetes: Metabolic and Genetic Associations

Autor: Peter J. Grant, M. H. Stickland, Michael W. Mansfield

Publikováno v: Thrombosis and Haemostasis. 77:357-361

SummaryAim: To identify whether levels of PAI-1 are elevated in relatives of NIDDM patients and the extent to which they relate to features of insulin resistance and to genotype at a common PAI-1 promoter polymorphism.Results: In 132 first-degree rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf81fdc91214fac29f845e52e1ab0773
https://doi.org/10.1055/s-0038-1655968

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Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G Promoter Polymorphism and Levels in Subjects with Cerebrovascular Disease

Autor: Andrew J. Catto, Angela M. Carter, John Bamford, J.A. Davies, M. H. Stickland, Peter J. Grant

Publikováno v: Thrombosis and Haemostasis. 77:730-734

SummaryThe exact role of the fibrinolytic system in the pathogenesis of stroke remains to be established. Elevated circulating levels of plasminogen activator inhibitor-1, the principle inactivator of the fibrinolytic system, have been related to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb7b30c0a2fe9f989b695c88ee751013
https://doi.org/10.1055/s-0038-1656042

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Promoter (4G/5G) plasminogen activator inhibitor-1 genotype in Pima Indians: relationship to plasminogen activator inhibitor-1 levels and features of the insulin resistance syndrome

Autor: D.K. Nagi, W. C. Knowler, L. J. McCormack, Vidya Mohamed-Ali, John S Yudkin, Peter J. Grant, Michael W. Mansfield, M. H. Stickland

Publikováno v: Diabetologia. 39:1512-1518

Elevated plasminogen activator inhibitor-1 may contribute to vascular disease in diabetes mellitus. Pima Indians have a low incidence of cardiovascular disease despite having a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM) which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704d953e35ee9952e024b611006a29ce
https://doi.org/10.1007/s001250050606

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Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Cerebrovascular Disease

Autor: Jennifer H. Barrett, John Bamford, Peter J. Grant, J. Andrew Davies, Andrew J. Catto, M. H. Stickland, Angela M. Carter

Publikováno v: Stroke. 27:435-440

Background and Purpose There is evidence that an allelic variation in the angiotensin-converting enzyme (ACE) gene may confer an increased risk of vascular disease. The roles of the ACE insertion/deletion polymorphism and circulating ACE levels are u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2872db6a34301f8484e025fccd2cc3a
https://doi.org/10.1161/01.str.27.3.435

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Environmental and Genetic Factors in Relation to Elevated Circulating Levels of Plasminogen Activator Inhibitor-1 in Caucasian Patients with Non-Insulin-Dependent Diabetes Mellitus

Autor: Michael W. Mansfield, Peter J. Grant, M. H. Stickland

Publikováno v: Thrombosis and Haemostasis. 74:842-847

SummaryTo investigate the interaction of metabolic and genetic factors in relation to PAI-1, genotype was determined at a 4G/5G polymorphism in the PAI-1 gene promoter and at a Hind III RFLP of the PAI-1 gene in 189 Caucasian NIDDM patients. PAI-1 le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d26729746a3de8a0683c3d3c69590982
https://doi.org/10.1055/s-0038-1649834

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Higher Levels of Microproteinuria in Asian Compared with European Patients with Diabetes Mellitus and Their Relationship to Dietary Protein Intake and Diabetic Complications

Autor: P. Martin, J.A. Davies, H. Tindall, M. H. Stickland, D. Nagi, S. Pinnock

Publikováno v: Diabetic Medicine. 11:37-41

Asian patients with diabetes have a higher prevalence of renal disease than their European counterparts. The aim of the study was to investigate the pattern of the renal excretion of proteins in 70 Asian and 70 European patients with diabetes and to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b1a7f4fb9c38f1e50fae4526a1d02f
https://doi.org/10.1111/j.1464-5491.1994.tb00227.x

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