Výsledky vyhledávání

Methods for testing familial aggregation of diseases in population-based samples: application to hodgkin lymphoma in swedish registry data

Autor: R. M. Pfeiffer, L. R. Goldin, N. Chatterjee, S. Daugherty, K. Hemminki, D. Pee, L. I. X, M. H. Gail

Publikováno v: Annals of Human Genetics. 68:498-508

We use data on lymphoma in families of Hodgkin lymphoma (HL) cases from the Swedish Family Cancer Database (Hemminki et al. 2001) to illustrate survival methods for detecting familial aggregation in first degree relatives of case probands compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a55c4f462c83f42555ffd21e6928c61
https://doi.org/10.1046/j.1529-8817.2003.00111.x

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Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine

Autor: Jimmie B. Vaught, S C Rossi, P Kiuru, Thomas R. Fears, D Sepkovic, Jennifer L. Donaldson, H L Bradlow, Roni T. Falk, M H Gail, Robert N. Hoover, K Wahala, Herman Adlercreutz, Regina G. Ziegler, Capri-Mara Fillmore, Pentti K. Siiteri

Publikováno v: Environmental Health Perspectives

Rapid and simple enzyme immunoassays (EIAs) were recently developed to measure 2-hydroxyestrone and 16alpha-hydroxyestrone in unextracted urine. The balance between these competing estrogen metabolism pathways may serve as a biomarker of breast cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ebf058d820083beb82250600a31032
http://europepmc.org/articles/PMC1469903

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A comparison of the power of two tests for qualitative interactions

Autor: S Piantadosi, M. H. Gail

Publikováno v: Statistics in Medicine. 12:1239-1248

'Qualitative' or 'crossover' interactions arise when a new treatment, compared with a control treatment, is beneficial in some subsets of patients and harmful in other subsets. We present a new range test for crossover interactions and compare it wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0036bddd22c97462767d6e5e795f3526
https://doi.org/10.1002/sim.4780121305

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Autor: Z, Li, J L, Gastwirth, M H, Gail

Publikováno v: Annals of human genetics. 69(Pt 3)

Both population based and family based case control studies are used to test whether particular genotypes are associated with disease. While population based studies have more power, cryptic population stratification can produce false-positive result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8149029fe273d1c3522912c01209ac8
https://pubmed.ncbi.nlm.nih.gov/15845034

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Considerations in the evaluation of surrogate endpoints in clinical trials. summary of a National Institutes of Health workshop

Autor: V G, De Gruttola, P, Clax, D L, DeMets, G J, Downing, S S, Ellenberg, L, Friedman, M H, Gail, R, Prentice, J, Wittes, S L, Zeger

Publikováno v: Controlled clinical trials. 22(5)

We report on recommendations from a National Institutes of Health Workshop on methods for evaluating the use of surrogate endpoints in clinical trials, which was attended by experts in biostatistics and clinical trials from a broad array of disease a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb9d73e5014e3e1ed459f22000f98171
https://pubmed.ncbi.nlm.nih.gov/11578783

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Pseudo-likelihood estimates of the cumulative risk of an autosomal dominant disease from a kin-cohort study

Autor: D F, Moore, N, Chatterjee, D, Pee, M H, Gail

Publikováno v: Genetic epidemiology. 20(2)

Wacholder et al. [1998: Am J Epidemiol 148:623-629] and Struewing et al. [1997: N Engl J Med 336:1401-1408] have recently proposed a design called the kin-cohort design to estimate the probability of developing disease (penetrance) associated with an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6a7241efc654ef28fb8a293d460a024
https://pubmed.ncbi.nlm.nih.gov/11180447

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Probability of helicobacter pylori infection based on IgG levels and other covariates using a mixture model

Autor: R M, Pfeiffer, M H, Gail, L M, Brown

Publikováno v: Journal of epidemiology and biostatistics. 5(5)

To use IgG antibody measurements to detect infection with Helicobacter pylori (H. pylori). one typically defines a cut-off value based on samples of persons presumed to be infected or uninfected. When there are no good 'gold standard' tests to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::587edfb90c7702b9c96566167ee67c53
https://pubmed.ncbi.nlm.nih.gov/11142602

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