Výsledky vyhledávání - "M. H. Buonarati"

Metabolism of 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine (PHIP) in mice

Autor: James S. Felton, Mark G. Knize, James A. Happe, C.J. Morris, M. H. Buonarati, Michelle Roper

Publikováno v: Carcinogenesis. 13:621-627

The metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), a heterocyclic amine carcinogen detected in cooked meats, was investigated in mice. In 3-methylcholanthrene-induced mice administered 0.1, 1.0 and 10 mg/kg [14C]PhIP (i.p.), u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd9e2facc4f42f5b26598095f766bb7
https://doi.org/10.1093/carcin/13.4.621

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Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 IA2

Autor: James S. Felton, James D. Tucker, J. L. Minkler, Larry H. Thompson, Rebekah W. Wu, M. H. Buonarati

Publikováno v: Mutagenesis. 6:253-259

We have utilized Chinese hamster ovary cell lines which stably express a murine cytochrome P450IA2 (P(3)450) cDNA to characterize more fully the mechanisms of genotoxicity of heterocyclic amines derived from cooked meats. To verify that these cell li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5b9b77fa85a9c3f1f50e7cbe12d10f
https://doi.org/10.1093/mutage/6.4.253

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Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by liver microsomes and isolated rabbit cytochrome P450 isozymes

Autor: J. A. Mazrimas, M. E. Veronese, Kenneth W. Turteltaub, M. H. Buonarati, James S. Felton, M. E. McManus, Mark G. Knize

Publikováno v: Carcinogenesis. 11:941-946

The cytochrome P450-dependent metabolism of the heterocyclic amine mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) has been determined. We investigated the in vitro metabolism of PhIP by polycyclic hydrocarbon-induced mouse and rabbit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3de63dcff041b68b1a4c2301514eb1
https://doi.org/10.1093/carcin/11.6.941

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Activation of 2-amino-1-methyl-6-phenyimidazo[4,5-b] pyridine (PhIP) to mutagenic metabolites

Autor: James S. Felton, M. H. Buonarati

Publikováno v: Carcinogenesis. 11:1133-1138

Metabolism of heterocyclic amines to N-hydroxy intermediates appears critical in the mutagenic and carcinogenic actions of these compounds. We have studied the murine hepatic microsomal and cytosolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65afd4694c0bda52e2795b17960a382e
https://doi.org/10.1093/carcin/11.7.1133

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Pharmacokinetic profiles in rats after intravenous, oral, or dermal administration of dapsone

Autor: D R, Helton, D W, Osborne, S K, Pierson, M H, Buonarati, R A, Bethem

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(8)

Dapsone is a potent anti-inflammatory and antibacterial agent that has been used extensively in the oral treatment of leprosy and dermatitis herpetiformis. This study compared the pharmacokinetic profile of dapsone in rats given a single oral or i.v.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::11e31e0e408af8118f1f471cd82bbdde
https://pubmed.ncbi.nlm.nih.gov/10901702

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Metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in nonhuman primates

Autor: E G, Snyderwine, R J, Turesky, M H, Buonarati, K W, Turteltaub, R H, Adamson

Publikováno v: Princess Takamatsu symposia. 23

The metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), three heterocyclic amine mutagens and carcino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b22565818bafe5af9a0466839d271e9f
https://pubmed.ncbi.nlm.nih.gov/8844797

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Mutagens and Carcinogens in Cooked Foods: Concentration, Potency and Risk

Autor: Kenneth W. Turteltaub, James D. Tucker, L.H. Thompson, Martin Vanderlaan, M. H. Buonarati, M. K. Knize, James S. Felton, Bruce E. Watkins, Robert T. Taylor

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781489926289

The cooking of foods derived from muscle generates heterocyclic amines that are very potent bacterial mutagens and carcinogens in mice, rats, and monkeys. Presently 12 mutagenic compounds have been found in cooked foods derived from the Western Diet.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6f843b95704b0803d95b2a38a9b5d0f
https://doi.org/10.1007/978-1-4899-2626-5_10

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