Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

Autor: Hala Fahs, Jia-Xuan Chen, Fabio Piano, Kristin C. Gunsalus, Matthias Selbach, Olivia Bay, Hin Hark Gan, Vinay K. Mayya, Thomas F. Duchaine, George Chung, P. Giselle Cipriani, John Zinno, Yu Guan, M. Gutwein

We describe MIP-1 and MIP-2, novel paralogous C. elegans germ granule components that interact with the intrinsically disordered MEG-3 protein. These proteins promote P granule condensation, form granules independently of MEG-3 in the postembryonic g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efe93d1bc55674377c9a5a1f4ecac397
https://doi.org/10.1101/2021.06.17.448425

Genome Architecture and Evolution of a Unichromosomal Asexual Nematode

Autor: Jessica Lucas, Mikhail Kovtun, Fabio Piano, Karin Kiontke, David H. A. Fitch, Kristin C. Gunsalus, Hélène Fradin, M. Gutwein, L. Ryan Baugh, Charles Zegar, David L. Corcoran

Publikováno v: Current biology : CB. 27(19)

Summary Asexual reproduction in animals, though rare, is the main or exclusive mode of reproduction in some long-lived lineages. The longevity of asexual clades may be correlated with the maintenance of heterozygosity by mechanisms that rearrange gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb5a571b5ad0b3a1ed2d50ec63ddb71
https://pubmed.ncbi.nlm.nih.gov/29017041

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

Autor: L. Dick, Mark S. Guyer, D. Mecenas, William C. Spencer, Ming Sin Cheung, Sebastian D. Mackowiak, Tao Liu, A. Vielle, Abby F. Dernburg, Mitzi Morris, Bradley I. Arshinoff, Sheldon J. McKay, Amber Leahey, Thea A. Egelhofer, Lukas Habegger, Michael Snyder, Teruaki Takasaki, Roger P. Alexander, Stuart K. Kim, Ashish Agarwal, Ting Han, A. Leo Iniguez, Eric L. Van Nostrand, Gos Micklem, S. Taing, Ekta Khurana, Joel Rozowsky, Beijing Wu, Steven Henikoff, Adrian Carr, Philip Green, Angie S. Hinrichs, A. Muroyama, Jason D. Lieb, Paul Lloyd, Yaniv Lubling, P. Scheid, Kevin Y. Yip, Stefan R. Henz, Chao Cheng, Jiang Du, Mei Zhong, P. Alves, Elicia Preston, Zhi John Lu, Vishal Khivansara, Robert H. Waterston, J. Janette, C. Slightam, Frank J. Slack, David M. Miller, Eo Stinson, Nikolaus Rajewsky, Eran Segal, Jing Leng, Tony Hyman, R. Robilotto, C. Shou, Gunnar Rätsch, Eric C. Lai, Mihail Sarov, X. Shirley Liu, Isabel J. Latorre, A. Chateigner, Francois Gullier, Raymond K. Auerbach, W. James Kent, Sergio Contrino, Jeremy Brouillet, Lincoln Stein, T. Phippen, Andrea Sboner, Marco Mangone, Georg Zeller, Hoang Pham, Mark Gerstein, Michael J. MacCoss, Siew Loon Ooi, Cathleen M. Brdlik, D. Vafeados, Nicole L. Washington, Andreas Rechtsteiner, Peter J. Good, Susan Strome, Galt P. Barber, Kristin C. Gunsalus, John I. Murray, Valerie Reinke, Luke Dannenberg, Masaomi Kato, M. Jensen, X. Feng, John Kim, Kahn Rhrissorrakrai, H. Holster, Kohta Ikegami, Christina M. Whittle, M. Gutwein, Rachel Lyne, Wei Niu, Richard J.H. Smith, LaDeana W. Hillier, P. Kolasinska-Zwierz, Heidi Rosenbaum, Andréa C. Dosé, Xingliang Zhou, Marc D. Perry, Rajkumar Sasidharan, Rebecca F. Lowdon, Arshad Desai, Z. Zha, J. Brennan, Guilin Wang, P. Ruzanov, Brent Ewing, Gennifer E. Merrihew, Kim Rutherford, Reto Gassmann, Elise A. Feingold, Fabio Piano, Julie Ahringer, E. Kephart, Lucas Lochovsky, Sevinc Ercan, Suzanna E. Lewis, Ksenia Voronina, Koon-Kiu Yan, Jorja G. Henikoff, Hyunjin Shin, Hiram Clawson, Ghia Euskirchen

Publikováno v: Science. 330:1775-1787

From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used to help to produce a functional organism (see the Perspective by Blaxter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af1c9379c54f3982c93a77444265918c
https://doi.org/10.1126/science.1196914

Label Free Cell-Tracking and Division Detection Based on 2D Time-Lapse Images For Lineage Analysis of Early Embryo Development

Autor: Marcelo Cicconet, M. Gutwein, Kristin C. Gunsalus, Davi Geiger

In this paper we report a database and a series of techniques related to the problem of tracking cells, and detecting their divisions, in time-lapse movies of mammalian embryos. Our contributions are (1) a method for counting embryos in a well, and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb963afc1fc9874be8fd85b9df32553
https://europepmc.org/articles/PMC4096606/

Rational design of temperature-sensitive alleles using computational structure prediction

Autor: Richard Bonneau, David Gresham, M. Gutwein, Kevin Drew, Glenn L. Butterfoss, Kristin C. Gunsalus, Dennis Shasha, Christopher S. Poultney

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e23947 (2011)
PLoS ONE

Temperature-sensitive (ts) mutations are mutations that exhibit a mutant phenotype at high or low temperatures and a wild-type phenotype at normal temperature. Temperature-sensitive mutants are valuable tools for geneticists, particularly in the stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28544d91b4d59fe9ad6e63752cc7f793
http://europepmc.org/articles/PMC3166291?pdf=render