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Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter

Autor: T Meulia, A Krumm, C Spencer, M Groudine

Publikováno v: Molecular and Cellular Biology. 12:4590-4600

A conditional block to transcription elongation provides one mechanism for controlling the steady-state levels of c-myc RNA in mammalian cells. Although prematurely terminated c-myc RNAs are not detectable in mammalian cells, truncated c-myc RNAs wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abdf5f235f4e07ce1509e1bfde1b4886
https://doi.org/10.1128/mcb.12.10.4590

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The control of mammalian DNA replication: a brief history of space and timing

Autor: D M, Cimbora, M, Groudine

Publikováno v: Cell. 104(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98c5ce9d653263c3312702fc6c477e3c
https://pubmed.ncbi.nlm.nih.gov/11257217

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Akademický článek

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Independent formation of DnaseI hypersensitive sites in the murine beta-globin locus control region

Autor: M A, Bender, M G, Mehaffey, A, Telling, B, Hug, T J, Ley, M, Groudine, S, Fiering

Publikováno v: Blood. 95(11)

Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally regulated. The expression of these genes both from the endogenous locus and from transgenes is strongly influenced by a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2676dbb25cee5d985add4fddbb6ccc4e
https://pubmed.ncbi.nlm.nih.gov/10828050

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Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus

Autor: D, Schübeler, C, Francastel, D M, Cimbora, A, Reik, D I, Martin, M, Groudine

Publikováno v: Genesdevelopment. 14(8)

We have investigated the mechanism, structural correlates, and cis-acting elements involved in chromatin opening and gene activation, using the human beta-globin locus as a model. Full transcriptional activity of the human beta-globin locus requires

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f71e72e5cce62505513d914f61dcdde8
https://pubmed.ncbi.nlm.nih.gov/10783166

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Analysis of mammalian cis-regulatory DNA elements by homologous recombination

Autor: S, Fiering, M A, Bender, M, Groudine

Publikováno v: Methods in enzymology. 306

The use of homologous recombination to modify and thereby functionally analyze cis-regulatory DNA elements in mammalian cells has become an important approach in mammalian gene expression research. We have emphasized the necessity of designing a syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01078d0c2f16ea63c4aeb2f4fe646884
https://pubmed.ncbi.nlm.nih.gov/10432447

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Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes

Autor: M, Bulger, J H, van Doorninck, N, Saitoh, A, Telling, C, Farrell, M A, Bender, G, Felsenfeld, R, Axel, M, Groudine, J H, von Doorninck

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 96(9)

In mouse and human, the beta-globin genes reside in a linear array that is associated with a positive regulatory element located 5' to the genes known as the locus control region (LCR). The sequences of the mouse and human beta-globin LCRs are homolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842a902485144008721e74aeda05b9a1
https://pubmed.ncbi.nlm.nih.gov/10220430

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Measurement of spontaneous and therapeutic agent-induced apoptosis with BCL-2 protein expression in acute myeloid leukemia

Autor: D E, Banker, M, Groudine, T, Norwood, F R, Appelbaum

Publikováno v: Blood. 89(1)

We have designed in vitro assays to investigate the possible association between apoptosis and chemotherapeutic sensitivity in acute myeloid leukemias (AMLs). Consistent low levels of spontaneous apoptosis were observed in myeloid cells from normal b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcce68c440d97e6fae0a1a62815fe1f6
https://pubmed.ncbi.nlm.nih.gov/8978298

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Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells

Autor: K J, Russell, L W, Wiens, G W, Demers, D A, Galloway, S E, Plon, M, Groudine

Publikováno v: Cancer research. 55(8)

We have examined the effect of abrogation of the G2 checkpoint on the radiosensitivity of G1 checkpoint-proficient and G1 checkpoint-deficient cells. A549 human lung adenocarcinoma cells were transduced with the E6 oncogene of the human papillomaviru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6899536ab774a3135dbe272affbc938b
https://pubmed.ncbi.nlm.nih.gov/7712467

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Akademický článek

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