Výsledky vyhledávání - "M. Goeritzer"

Akademický článek

Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. F. Graier, D. Kratky, E. Malle, W. Sattler

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-28 (2017)

Abstract Background Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1–6) and are indispensible for brain development and function of the nervous system. However, under neuroinfla

Externí odkaz: https://doaj.org/article/275bdff4de584594a8741445fdbfe635

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The role of endothelial adipose triglyceride lipase (ecATGL) in heart failure with preserved ejection fraction (HFpEF)

Autor: J Schwanbeck, M Stahnke, M Goeritzer, D Kolb, E E Kershaw, R Zechner, A Foryst-Ludwig, U Kintscher

Publikováno v: European Heart Journal. 43

Background and objectives Obesity is one of the major drivers of heart failure with preserved ejection fraction (HFpEF). Endothelial cells (EC) have an important barrier function including the control of lipid transport from the coronary circulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72609274dc20d60d5cd128bf9d138bf2
https://doi.org/10.1093/eurheartj/ehac544.2949

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Additional file 4: Figure S4. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

TCLPA5 inhibits the phosphorylation of pro-inflammatory transcription factors. BV-2 microglia cells were cultured in 6-well plates and serum-starved overnight. Cells were treated with LPA (1 μM) or LPA (1 μM) in the presence of (A) TCLPA5 (5 μM) f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::038c41818bc9280da15f894364d5e682

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Additional file 6: Figure S6. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

PKD family members control the secretion of pro-inflammatory cytokines and chemokines. BV-2 cells were cultured on 12-well plates; serum-starved o/n and the supernatants were collected after incubation with DMSO, DMSO plus LPA (1 μM) or LPA (1 μM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eccd9574d82dfc20c4f584c668e149c2

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Additional file 3: Figure S3. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

LPA promotes activation of pro-inflammatory transcription factors in BV-2 cells. Serum-starved (A) BV-2 cells were treated with 0.1% BSA (control) or LPA (1 μM) for the indicated time periods, the cellular protein lysates were collected and phosphor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b8b625a41bb2501c037d35893fad550

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Additional file 5: Figure S5. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

The phosphorylation of pro-inflammatory transcription factors is under PKD family control. BV-2 cells, serum-starved overnight and treated with LPA (1 μM) or LPA (1 μM) in the presence of (A) CRT0066101 (1 μM) for the indicated time periods. Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c2002f48134aa1aa2f2890b533f58fe

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Additional file 2: Figure S2. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

PKD family inhibition abrogates LPA-mediated downstream signaling. (A) BV-2 microglia cells were cultured in 6-well plates, serum-starved overnight and preincubated with CRT0066101 (‘CRT’, 1 μM) for the indicated time periods before incubation w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a048c985b2ba7fee0f31c2157ce645a5

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Additional file 1: Figure S1. of Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Autor: I. Plastira, E. Bernhart, M. Goeritzer, T. DeVaney, H. Reicher, A. Hammer, B. Lohberger, A. Wintersperger, B. Zucol, W. Graier, D. Kratky, E. Malle, W. Sattler

LPAR5 controls LPA-mediated downstream signaling. (A) BV-2 microglia cells were cultured in 6-well plates and serum-starved overnight. The cells were preincubated with TCLPA5 (5 μM) for the indicated times and then incubated with LPA (1 μM) or LPA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3e144702f6855fb7514406f3493026

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