Zobrazeno 1 - 10
of 250
pro vyhledávání: '"M. Gittelman"'
Autor:
Rachel M. Gittelman, Enrico Lavezzo, Thomas M. Snyder, H. Jabran Zahid, Cara L. Carty, Rebecca Elyanow, Sudeb Dalai, Ilan Kirsch, Lance Baldo, Laura Manuto, Elisa Franchin, Claudia Del Vecchio, Monia Pacenti, Caterina Boldrin, Margherita Cattai, Francesca Saluzzo, Andrea Padoan, Mario Plebani, Fabio Simeoni, Jessica Bordini, Nicola I. Lorè, Dejan Lazarević, Daniela M. Cirillo, Paolo Ghia, Stefano Toppo, Jonathan M. Carlson, Harlan S. Robins, Andrea Crisanti, Giovanni Tonon
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
T cells play a prominent role in orchestrating the immune response to viral diseases, but their role in the clinical presentation and subsequent immunity to SARS-CoV-2 infection remains poorly understood. As part of a population-based survey of the m
Externí odkaz:
https://doaj.org/article/ef4ff663260a45f7ba60d15fe32db9e4
Autor:
Rebecca Elyanow, Thomas M. Snyder, Sudeb C. Dalai, Rachel M. Gittelman, Jim Boonyaratanakornkit, Anna Wald, Stacy Selke, Mark H. Wener, Chihiro Morishima, Alexander L. Greninger, Michael Gale Jr., Tien-Ying Hsiang, Lichen Jing, Michael R. Holbrook, Ian M. Kaplan, H. Jabran Zahid, Damon H. May, Jonathan M. Carlson, Lance Baldo, Thomas Manley, Harlan S. Robins, David M. Koelle
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
BACKGROUND Measuring the immune response to SARS-CoV-2 enables assessment of past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell responses, but these responses vary with disease severity and individual characterist
Externí odkaz:
https://doaj.org/article/c720e1a7f2ea4a9bb6e8db6d06e7b8ab
Autor:
Alexander M. Xu, Dalin Li, Joseph E. Ebinger, Emebet Mengesha, Rebecca Elyanow, Rachel M. Gittelman, Heidi Chapman, Sandy Joung, Gregory J. Botwin, Valeriya Pozdnyakova, Philip Debbas, Angela Mujukian, John C. Prostko, Edwin C. Frias, James L. Stewart, Arash A. Horizon, Noah Merin, Kimia Sobhani, Jane C. Figueiredo, Susan Cheng, Ian M. Kaplan, Dermot P. B. McGovern, Akil Merchant, Gil Y. Melmed, Jonathan Braun
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
T-cells specifically bind antigens to induce adaptive immune responses using highly specific molecular recognition, and a diverse T-cell repertoire with expansion of antigen-specific clones can indicate robust immune responses after infection or vacc
Externí odkaz:
https://doaj.org/article/b9f0c827dbb943ba89561bcaec2c555a
Autor:
Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou, Rachel M. Gittelman, Jun Li, Won-Chul Lee, Junya Fujimoto, Carmen Behrens, Xiaoke Liu, Feng Wang, Kelly Quek, Chunlin Wang, Farrah Kheradmand, Runzhe Chen, Chi-Wan Chow, Heather Lin, Chantale Bernatchez, Ali Jalali, Xin Hu, Chang-Jiun Wu, Agda Karina Eterovic, Edwin Roger Parra, Erik Yusko, Ryan Emerson, Sharon Benzeno, Marissa Vignali, Xifeng Wu, Yuanqing Ye, Latasha D. Little, Curtis Gumbs, Xizeng Mao, Xingzhi Song, Samantha Tippen, Rebecca L. Thornton, Tina Cascone, Alexandra Snyder, Jennifer A. Wargo, Roy Herbst, Stephen Swisher, Humam Kadara, Cesar Moran, Neda Kalhor, Jianhua Zhang, Paul Scheet, Ara A. Vaporciyan, Boris Sepesi, Don L. Gibbons, Harlan Robins, Patrick Hwu, John V. Heymach, Padmanee Sharma, James P. Allison, Veera Baladandayuthapani, Jack J. Lee, Mark M. Davis, Ignacio I. Wistuba, P. Andrew Futreal, Jianjun Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tiss
Externí odkaz:
https://doaj.org/article/15a3818a702a41f18e727456b0714f76
Autor:
Seth M Pollack, Robin L Jones, Marissa Vignali, Brett A Schroeder, Shihong Zhang, Jose G Mantilla, Kimberly S Smythe, Jean S Campbell, Robert H Pierce, Lee D Cranmer, Michael J Wagner, Bonnie J LaFleur, Brian C Schulte, Natalie A LaFranzo, Rachel M Gittelman, Kevin C Flanagan, Julie Rytlewski, Laura Riolobos, Teresa S Kim, Eleanor Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/484b994ebf74450d8db188497c041c18
Autor:
Sarah A Johnson, Spencer L Seale, Rachel M Gittelman, Julie A Rytlewski, Harlan S Robins, Paul A Fields
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0249484 (2021)
The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random proce
Externí odkaz:
https://doaj.org/article/dee177985d1643a8a813d6a4f72cdbb8
Autor:
Samir N. Khleif, Seema Gupta, Mikayel Mkrtichyan, John E. Janik, Scott A. Hammond, Harlan Robins, Catherine Sanders, Erik Yusko, Rachel M. Gittelman, Pankaj Gaur, Sudha Ananth, Peng Zeng, Vivek Verma, Shamim Ahmad, Rajeev K. Shrimali
Evaluation of expression of OX40, PD-1, and PD-L1 and proliferation and apoptosis in CD8+ T-cells in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c4154d895a255c0807381cb59d5a80
https://doi.org/10.1158/2326-6066.22539584.v1
https://doi.org/10.1158/2326-6066.22539584.v1
Autor:
Samir N. Khleif, Seema Gupta, Mikayel Mkrtichyan, John E. Janik, Scott A. Hammond, Harlan Robins, Catherine Sanders, Erik Yusko, Rachel M. Gittelman, Pankaj Gaur, Sudha Ananth, Peng Zeng, Vivek Verma, Shamim Ahmad, Rajeev K. Shrimali
Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 are being tested in the clinic to achieve improved antitumor effects. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0801e54b2055f9ba4cd12f3c386703
https://doi.org/10.1158/2326-6066.c.6549134.v1
https://doi.org/10.1158/2326-6066.c.6549134.v1
Autor:
Samir N. Khleif, Seema Gupta, Mikayel Mkrtichyan, John E. Janik, Scott A. Hammond, Harlan Robins, Catherine Sanders, Erik Yusko, Rachel M. Gittelman, Pankaj Gaur, Sudha Ananth, Peng Zeng, Vivek Verma, Shamim Ahmad, Rajeev K. Shrimali
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615d975cb0e07c871f0a46f68a354f77
https://doi.org/10.1158/2326-6066.22539587
https://doi.org/10.1158/2326-6066.22539587
Autor:
Dalin Li, Alexander Xu, Emebet Mengesha, Rebecca Elyanow, Rachel M Gittelman, Heidi Chapman, John C Prostko, Edwin C Frias, James L Stewart, Valeriya Pozdnyakova, Philip Debbas, Angela Mujukian, Arash A Horizon, Noah Merin, Sandy Joung, Gregory J Botwin, Kimia Sobhani, Jane C Figueiredo, Susan Cheng, Ian M Kaplan, Dermot P B McGovern, Akil Merchant, Gil Y Melmed, Jonathan Braun
Publikováno v:
Inflammatory Bowel Diseases. 28:1130-1133
Lay Summary T-cell and antibody responses to severe acute respiratory syndrome coronavirus 2 vaccination in inflammatory bowel disease patients are poorly correlated. T-cell responses are preserved by most biologic therapies, but augmented by anti-tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833af4b439c25ed1e3a2b049743e780e
https://doi.org/10.1093/ibd/izac071
https://doi.org/10.1093/ibd/izac071