Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress

Autor: Simone Mori, Shuei Sugama, William Nguyen, Tatiana Michel, M. Germana Sanna, Manuel Sanchez-Alavez, Rigo Cintron-Colon, Gianluca Moroncini, Yoshihiko Kakinuma, Pamela Maher, Bruno Conti

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-10 (2017)

Abstract Background The majority of Parkinson’s disease (PD) cases are sporadic and idiopathic suggesting that this neurodegenerative disorder is the result of both environmental and genetic factors. Stress and neuroinflammation are among the facto

Externí odkaz: https://doaj.org/article/5950a5a111e644f3b24f9e96bcbaf71f

Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction

Autor: William B. Kiosses, Emanuela Repetto, Sean Riley, Yasushi Kohno, Stuart M. Cahalan, M. Germana Sanna, Joan Heller Brown, Andrew D. McCulloch, Nhan Nguyen, Pedro J. Gonzalez-Cabrera, Steven J. Brown, Nora B. Leaf, Lusine Abgaryan, Kevin P. Vincent, Hugh Rosen

Publikováno v: Molecular pharmacology, vol 89, iss 1
Sanna, MG; Vincent, KP; Repetto, E; Nguyen, N; Brown, SJ; Abgaryan, L; et al.(2016). Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. MOLECULAR PHARMACOLOGY, 89(1), 176-186. doi: 10.1124/mol.115.100222. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/19v1t1kw

The molecular pharmacology of the G protein-coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P3 antagonist, SPM-354, with in vivo activity, has been u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59acdba56a92adf62fc93f6d3ca82d7
https://doi.org/10.1124/mol.115.100222

Modulating tone: the overture of S1P receptor immunotherapeutics

Autor: Pedro J. Gonzalez-Cabrera, Stuart M. Cahalan, M. Germana Sanna, Anthony S. Don, David Marsolais, Hugh Rosen

Publikováno v: Immunological Reviews. 223:221-235

Summary: Modulation of complex functions within the immune system has proven to be surprisingly sensitive to alterations in the lysophospholipid sphingosine 1-phosphate (S1P) receptor-ligand rheostat. This has become increasingly evident from both ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609fe261a18ca00d64b92a167a00313b
https://doi.org/10.1111/j.1600-065x.2008.00645.x

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

Autor: Hugh Rosen, M. Germana Sanna, Ian Parker, Sheng-Kai Wang, Melanie P. Matheu, Sindy H. Wei, Chi-Huey Wong, Euijung Jo, Michael D. Cahalan

Publikováno v: Nature Immunology. 6:1228-1235

Sphingosine 1-phosphate type 1 (S1P(1)) receptor agonists cause sequestration of lymphocytes in secondary lymphoid organs by a mechanism that is not well understood. One hypothesis proposes that agonists act as 'functional antagonists' by binding and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9657bbc9adf0627fd754a21db595f5b8
https://doi.org/10.1038/ni1269

ILPIP, a Novel Anti-apoptotic Protein That Enhances XIAP-mediated Activation of JNK1 and Protection against Apoptosis

Autor: Quinn Deveraux, M. Germana Sanna, Betty Chuang, Jean da Silva Correia, Lorien M. Paulson, Ying Luo, Richard J. Ulevitch, Binh Nguyen

Publikováno v: Journal of Biological Chemistry. 277:30454-30462

We have previously described a new aspect of the Inhibitor of Apoptosis (IAP) family of proteins anti-apoptotic activity that involves the TAK1/JNK1 signal transduction pathway (1,2). Our findings suggest the existence of a novel mechanism that regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530376b8c4bfc2a4425a3cbb5ef89c8b
https://doi.org/10.1074/jbc.m203312200