Establishment of protein delivery systems targeting podocytes.

Autor: Wen Chih Chiang, Tessa M Geel, Mehmet M Altintas, Sanja Sever, Marcel H J Ruiters, Jochen Reiser

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11837 (2010)

Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular capillaries expose podocytes to large quantities of both plasma and urinary components and thus ar

Externí odkaz: https://doaj.org/article/cecbf0d0b3674acea3d874348c5afcb6

The past and presence of gene targeting: from chemicals and DNA via proteins to RNA

Autor: T. M. Geel, Marcel H. J. Ruiters, Paola B. Arimondo, Ludovic Halby, K. E. Niezen-Koning, L Andrade Ruiz, Marianne G. Rots, Robbert H. Cool, D C Voshart

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences
Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2018, 373 (1748), pp.20170077. ⟨10.1098/rstb.2017.0077⟩

The ability to target DNA specifically at any given position within the genome allows many intriguing possibilities and has inspired scientists for decades. Early gene-targeting efforts exploited chemicals or DNA oligonucleotides to interfere with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82f066ed6911611e79945de7b701c90
https://hal.archives-ouvertes.fr/hal-02383681

Selective targeting of adenovirus to αvβ3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies

Autor: Anna Rita Bellu, Hidde J. Haisma, Anu Kariath, T. M. Geel, Arend Bouma, Marianne G. Rots, Gera Kamps

Publikováno v: International Journal of Pharmaceutics, 391(1-2), 155-161. Elsevier Bedrijfsinformatie b.v.

Tumor angiogenesis is a prominent mechanism, driving the development and progression of solid tumors and the formation of cancer cell metastasis. Newly formed tumor vessels represent an elective target for the activity and the delivery of cancer ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc69683b41671138507318465f76940e
https://doi.org/10.1016/j.ijpharm.2010.02.032

Combining counterflow centrifugal elutriation and glycoprotein lb-dependent purification of human megakaryocytes: Efficacy and selectivity

Autor: Adri Zevenbergen, Gert J. Ossenkoppele, B. J. M. Geel, Mart M. A. C. Langenhuijsen, F. Rodriguez, Peter C. Huijgens, P. W. Wijermans, Elisabeth C.M. van Pampus

Publikováno v: European Journal of Haematology. 47:299-304

To estimate the efficacy of human megakaryocyte purification techniques, mixtures of known numbers of megakaryocytes with a known ploidy range and of bone marrow or peripheral blood mononuclear cells were made. These artificial bone marrow samples we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebd889f1b9cf10330649ff86cdc3ad6
https://doi.org/10.1111/j.1600-0609.1991.tb01575.x

THE IMPACT OF FAMILY PLANNING SUPPLY FACTORS ON UNMET NEED IN RURAL EGYPT 1988Ð1989

Autor: Fiona Steele, Fatma El-Zahraa M. M. Geel

Publikováno v: Journal of Biosocial Science. 31:311-326

This paper examines the reasons for the high level of unmet need for contraception in rural Egypt, using data from the individual survey and service availability module of the 1988Ð89 Egypt Demographic and Health Survey. Two broad sets of potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74ce4669576e51f91f7fddef887b6ffc
https://doi.org/10.1017/s0021932099003119