A 20 amino acid synthetic peptide of a region from the 55 kDa human TNF receptor inhibits cytolytic and binding activities of recombinant human tumour necrosis factorin vitro

Autor: Elizabeth K. Innins, Chenduen Hwang, M. Gatanaga, Gale A. Granger, Robert S. Yamamoto, Tetsuya Gatanaga

Publikováno v: Proceedings of the Royal Society of London. Series B: Biological Sciences. 245:115-119

Tumour Necrosis Factor (TNF) and Lymphotoxin (LT) can exert a wide range of effects on cells and tissues and they are important effector molecules in cell mediated immunity. All these effects are induced subsequent to the binding of these cytokines t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e92eb316165770209431695f4ff497a
https://doi.org/10.1098/rspb.1991.0096

Prostaglandin-E2 regulation of tumor necrosis factor receptor release in human monocytic THP-1 cells

Autor: Sue S. Choi, Gale A. Granger, Tetsuya Gatanaga, M. Gatanaga

Publikováno v: Choi, SS; Gatanaga, M; Granger, GA; & Gatanaga, T. (1996). Prostaglandin-E2regulation of tumor necrosis factor receptor release in human monocytic THP-1 cells. Cellular Immunology, 170(2), 178-184. doi: 10.1006/cimm.1996.0150. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/984924m5

Recent in vitro studies indicate that tumor necrosis factor (TNF) production in human monocytic THP-1 cells is suppressed by action of arachidonic acid metabolite prostaglandin-E2 (PGE2). PGE2 stimulation of human monocytic cell line THP-1 demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbe04dae479e2197cbbbbd8d4146d08
https://pubmed.ncbi.nlm.nih.gov/8660816

Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro

Autor: C Hwang, M Gatanaga, G A Granger, T Gatanaga

Publikováno v: Hwang, C; Gatanaga, M; Granger, GA; & Gatanaga, T. (1993). Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro. Journal of Immunology, 151(10), 5631-5638. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6ch3n0wc

The mechanism involved in the release of the soluble forms of 55 and 75 kDa TNF and lymphotoxin (LT) membrane receptors was studied in a continuous human monocytic cell line, THP-1, in vitro. THP-1 cells were found to spontaneously release soluble fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d60950b8a6f05efae15495f167ed13
http://www.escholarship.org/uc/item/6ch3n0wc

The role of lymphotoxin in the IL-2-driven differentiation of human lymphokine-activated T-killer (T-LAK) cells in vitro

Autor: Y, Abe, M, Van Eden, M, Gatanaga, F I, Wang, H D, Brightbill, G A, Granger, T, Gatanaga

Publikováno v: Lymphokine and cytokine research. 12(5)

Brief stimulation of human peripheral blood mononuclear cells with PHA and subsequent coculture with IL-2 results by 5 days in cultures of human lymphokine-activated killer (T-LAK) cells. While IL-2 drives the proliferation of these cells in vitro, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72d85487293c2e6921d9a46aac7b861e
https://pubmed.ncbi.nlm.nih.gov/8260536

Role of 55- and 75-kDa tumor necrosis factor membrane receptors in the regulation of intercellular adhesion molecules-1 expression by HL-60 human promyelocytic leukemia cells in vitro

Autor: Y, Abe, M, Gatanaga, Y, Osuka, S, Kimura, R A, Burger, G A, Granger, T, Gatanaga

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 150(11)

Most human cells express two TNF and lymphotoxin (LT) membrane receptors (TNF-R), of 55 and 75 kDa. The regulatory effect of these two receptors on intercellular adhesion molecules (ICAM-1) expression was examined in various human cell lines in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc8ac46ba85e868bbb0c70d9d884ec2f
https://pubmed.ncbi.nlm.nih.gov/8098725