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Autor: Y.X. Wang, K.-S. Choi, M. Gaster, C. Atkin, V. Borodulin, Y. Kachanov

Opposition control of artificially initiated turbulent spots in a laminar boundary layer was carried out in a low-turbulence wind tunnel with the aim to delay transition to turbulence by modifying the turbulent structure within the turbulent spots. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fd6b038ffdfcb72b10bdaef6242828

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Hematopoietic stem cells (+iPS) (PP-010)

Autor: J. Kim, R. Zhang, M. Kassem, M. Torabi Rahvar, B. Altinok, T. Barington, M. Jeddi-Tehrani, R. McKenzie, H. Yang, Y. Obata, G. Kumar, R. McIntosh, J. Kato, T. Ben Othman, H. Nakauchi, H. Hisha, J. Baran, K. Shimoji, S. Mise-Omata, A. Zarnani, J. Moon, F. Bojin, M. Gaster, Y. S. Lee, S. Darzi, S. Kazemnejad, J. Joh, M. Bejaoui, H. Wada, X. Wang, A. Abdelkafi, H. J. Sabir, Q. Li, L. Pulaski, J. O. Nehlin, C. Tatu, H. Suzukiand, F. Mallouli, M. Akhondi, F. Jenhani, N. Ben Azouna, I. Siska, T. S. Doi, N. Nishio, A. Walczak-Drzewiecka, K. Isobe, K. Seino, M. Stec, S. Kim, K. Entezami, M. Ratajewski, C. Bunu Panaitescu, J. Hwang, B. Ishizuka, A. Karadag, S. Kojo, T. Mizokami, A. Sunguroglu, H. Kanzaki, Y. Sato, N. Okamoto, B. Mytar, H. Chelli, Z. Cheng, T. Ozkan, V. Anderson, S. Aydos, A. Isa, V. Paunescu, Y. Choi, T. Yamaguchi, A. Wood, G. Tanasie, A. Karabay, T. Fukazawa, D. Nistor, S. Ito, J. Domenech, T. Andersen, S. Bozkurt, J. Dastych, M. Zembala, S. Ikehara

Publikováno v: International Immunology. 22:i76-i79

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da22d08293f6538bf87cb534387407c1
https://doi.org/10.1093/intimm/dxq085

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Akademický článek

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The Selective 5-HT1B Receptor Inverse Agonist 1‘-Methyl-5-[[2‘-methyl-4‘- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4‘-piperidine] (SB-224289) Potently Blocks Terminal 5-HT Autoreceptor Function Both in Vitro and in Vivo

Publikováno v: Journal of Medicinal Chemistry. 41:1218-1235

5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT1B and 5-HT1D receptors (previously known as 5-HT1Dbeta and 5-HT1Dalpha, respectively), although encoded b

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https://doi.org/10.1021/jm970457s

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Overview Central & Peripheral Nervous System: 5-HT4receptor antagonists

Autor: Gareth J. Sanger, Laramie M Gaster

Publikováno v: Expert Opinion on Therapeutic Patents. 4:323-332

(1994). Overview Central & Peripheral Nervous System: 5-HT4 receptor antagonists. Expert Opinion on Therapeutic Patents: Vol. 4, No. 4, pp. 323-332.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8abf6d47493b7f3deef71f52878e2b2f
https://doi.org/10.1517/13543776.4.4.323

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(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide

Autor: Keith Raymond Mulholland, E.S. Ellis, S Starr, Andrew John Jennings, Wyman Paul Adrian, L M Gaster, Frank King, Graham Francis Joiner, Kay A. Wardle, Sh K Rahman

Publikováno v: Journal of Medicinal Chemistry. 36:4121-4123

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef304443d22d699a5a9efced745d625
https://doi.org/10.1021/jm00077a018

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GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?

Autor: M, Gaster, P, Staehr, H, Beck-Nielsen, H D, Schrøder, A, Handberg

Publikováno v: Diabetes. 50(6)

To gain further insight into the mechanisms underlying muscle insulin resistance, the influence of obesity and type 2 diabetes on GLUT4 immunoreactivity in slow and fast skeletal muscle fibers was studied. Through a newly developed, very sensitive me

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https://pubmed.ncbi.nlm.nih.gov/11375332

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Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent

Publikováno v: Journal of medicinal chemistry. 43(6)

The evolution, synthesis, and biological activity of a novel series of 5-HT(2C) receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT(2C) affinity and selectivity over 5-HT(2A) receptors. In additio

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https://pubmed.ncbi.nlm.nih.gov/10737744

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SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity

Autor: J V, Selkirk, C, Scott, M, Ho, M J, Burton, J, Watson, L M, Gaster, L, Collin, B J, Jones, D N, Middlemiss, G W, Price

Publikováno v: British journal of pharmacology. 125(1)

1. Human 5-HT1B (h5-HT1B) and human 5-HT1D (h5-HT1D) receptors show remarkably similar pharmacology with few compounds discriminating the receptors. We report here on a novel compound, SB-224289 (1'-Methyl-5-[[2'-methyl-4'-(5-methyl- 1,2,4-oxadiazol-

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https://pubmed.ncbi.nlm.nih.gov/9776361

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