Context-restricted PD-(L)1 checkpoint agonism by CTLA4-Ig therapies inhibits T cell activity

Autor: Ethan P. Oxley, Nadia J. Kershaw, Cynthia Louis, Katharine J. Goodall, Maximilian M. Garwood, Skye Min Jee Ho, Veronica T.F. Voo, Hae-Young Park, Josephine Iaria, Lilian L.L. Wong, Ariel G. Lebenbaum, Stephanie Wiranata, Ee Shan Pang, Emily S.J. Edwards, Damian B. D’Silva, Jacinta Hansen, Menno C. van Zelm, Meredith O’Keeffe, P. Mark Hogarth, Nicole M. Haynes, Nicholas D. Huntington, Ian P. Wicks, Ross A. Dickins

Publikováno v: Cell Reports, Vol 43, Iss 10, Pp 114834- (2024)

Summary: T cell surface CTLA4 sequesters the costimulatory ligands CD80 and CD86 on antigen-presenting cells (APCs) to prevent autoimmunity. Therapeutic immunosuppression by recombinant CTLA4-immunoglobulin (Ig) fusion proteins, including abatacept,

Externí odkaz: https://doaj.org/article/6c8609b2d6c447c2abb2c3c69d1e33ba

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Autor: Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic

Externí odkaz: https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71

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Sex-related differences in aging rate areassociated with sex chromosome system inamphibians

Autor: Hugo Cayuela, Jean‐François Lemaître, Jean‐Paul Léna, Victor Ronget, Iñigo Martínez‐Solano, Erin Muths, David S. Pilliod, Benedikt R. Schmidt, Gregorio Sánchez‐Montes, Jorge Gutiérrez‐Rodríguez, Graham Pyke, Kurt Grossenbacher, Omar Lenzi, Jaime Bosch, Karen H. Beard, Lawrence L. Woolbright, Brad A. Lambert, David M. Green, Nathalie Jreidini, Justin M. Garwood, Robert N. Fisher, Kathleen Matthews, David Dudgeon, Anthony Lau, Jeroen Speybroeck, Rebecca Homan, Robert Jehle, Eyup Başkale, Emiliano Mori, Jan W. Arntzen, Pierre Joly, Rochelle M. Stiles, Michael J. Lannoo, John C. Maerz, Winsor H. Lowe, Andrés Valenzuela‐Sánchez, Ditte G. Christiansen, Claudio Angelini, Jean‐Marc Thirion, Juha Merilä, Guarino R. Colli, Mariana M. Vasconcellos, Taissa C. V. Boas, Ísis da C. Arantes, Pauline Levionnois, Beth A. Reinke, Cristina Vieira, Gabriel A. B. Marais, Jean‐Michel Gaillard, David A. W. Miller

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Evolution (Lancaster, Pa. : Online) (2021). doi:10.1111/evo.14410
info:cnr-pdr/source/autori:Cayuela H., Lemaitre J.F., Léna J.P., Ronget V., Martinez-Solano I., Muths E., Pilliod D.S., Schmidt B.R., Sànchez-Montes G., Gutièrrez-Rodriguez J., Pyke G., Grossenbacher K., Lenzi O., Bosch J., Beard K.H., Woolbright L.L., Lambert B.A., Green D.M., Jreidini N., Garwood J.M., Fischer R.N., Matthews K., Dudgeon D., Lau A., Speybroek J., Homan R., Jehle R., Baskale E., Mori E., Arntzen J.W., Joly P., Stiles R.M., Lannoo M.J., Maerz J.C., Lowe W.H., Valenzuela-Sanchez A., Christiansen D.G., Angelini C., Thirion J.M., Merilä J., Colli G.R., Vasconcellos M.M., Boas T.C.V., Arantes I.D.C., Levionnois P., Reinke B.A., Vieira C., Marais G.A.B., Gaillard J.M., Miller D.A.W./titolo:Sex-related differences in aging rate are associated with sex chromosome systems in Amphibians/doi:10.1111%2Fevo.14410/rivista:Evolution (Lancaster, Pa. : Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Evolution, 76(2), 346-356
Evolution-International Journal of Organic Evolution
Evolution-International Journal of Organic Evolution, 2022, 76 (2), pp.346-356. ⟨10.1111/evo.14410⟩
Wildland Resources Faculty Publications

Sex-related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determinationsystems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e649cfe7199ae2f729c93aa8a25711f
http://hdl.handle.net/10261/268165