Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M. Gartz Hanson"'
Publikováno v:
eLife, Vol 4 (2015)
Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous ani
Externí odkaz:
https://doaj.org/article/9743179c702a4abd8f678b58ef8d1e1f
Autor:
Emily A. Bates, M. Gartz Hanson, David Sept, Jeffrey K. Moore, Daniel V. Sietsema, Lee Niswander, Jayne Aiken
Publikováno v:
Developmental Biology. 409(2):406-419
Mutations in the microtubule cytoskeleton are linked to cognitive and locomotor defects during development, and neurodegeneration in adults. How these mutations impact microtubules, and how this alters function at the level of neurons is an important
Autor:
Lee Niswander, M. Gartz Hanson
Publikováno v:
Developmental Biology. 404:76-87
Locomotion and respiration require motor axon connectivity and activation of the neuromuscular junction (NMJ). Through a forward genetic screen for muscle weakness, we recently reported an allele of ryanodine receptor type 1 (Ryr1AG). Here we reveal
Autor:
Jing Han, Xiang Li, Melanie D. Mark, Peter Hegemann, Lynn T. Landmesser, Hillel J. Chiel, M. Gartz Hanson, Stefan Herlitze, Davina V. Gutierrez
Publikováno v:
Proceedings of the National Academy of Sciences. 102:17816-17821
Techniques for fast noninvasive control of neuronal excitability will be of major importance for analyzing and understanding neuronal networks and animal behavior. To develop these tools we demonstrated that two light-activated signaling proteins, ve
Autor:
Christopher P. Myers, Simon Gosgnach, James B. Aimone, M. Gartz Hanson, Fred H. Gage, Samuel L. Pfaff, Lynn T. Landmesser, Kuo-Fen Lee, Joseph W. Lewcock
Publikováno v:
Neuron. 46(1):37-49
SummaryRhythmic limb movements are controlled by pattern-generating neurons within the ventral spinal cord, but little is known about how these locomotor circuits are assembled during development. At early stages of embryogenesis, motor neurons are s
Autor:
Lynn T. Landmesser, M. Gartz Hanson
Publikováno v:
Neuron. 43(5):687-701
Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at pre
Publikováno v:
Developmental biology. 395(1)
Peroxisome biogenesis disorders (PBD) are autosomal recessive disorders in humans characterized by skeletal, eye and brain abnormalities. Despite the fact that neurological deficits, including peripheral nervous system (PNS) defects, can be observed
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous ani
Publikováno v:
Brain research reviews. 57(1)
During embryonic development chick and mouse spinal cords are activated by highly rhythmic episodes of spontaneous bursting activity at very early stages, while motoneurons are still migrating and beginning to extend their axons to the base of the li