Zobrazeno 1 - 10
of 177
pro vyhledávání: '"M. GILKES"'
Autor:
Inês Godet, Harsh H. Oza, Yi Shi, Natalie S. Joe, Alyssa G. Weinstein, Jeanette Johnson, Michael Considine, Swathi Talluri, Jingyuan Zhang, Reid Xu, Steven Doctorman, Delma Mbulaiteye, Genevieve Stein-O’Brien, Luciane T. Kagohara, Cesar A. Santa-Maria, Elana J. Fertig, Daniele M. Gilkes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Hypoxia occurs in 90% of solid tumors and is associated with metastasis and mortality. Breast cancer cells that experience intratumoral hypoxia are 5x more likely to develop lung metastasis in animal models. Using spatial transcriptomics, we
Externí odkaz:
https://doaj.org/article/426e0d8a44dd43e7bc5d581380aed53f
Autor:
Zachary J. Rogers, Thibault Colombani, Saad Khan, Khushbu Bhatt, Alexandra Nukovic, Guanyu Zhou, Benjamin M. Woolston, Cormac T. Taylor, Daniele M. Gilkes, Nikolai Slavov, Sidi A. Bencherif
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract In oxygen (O2)‐controlled cell culture, an indispensable tool in biological research, it is presumed that the incubator setpoint equals the O2 tension experienced by cells (i.e., pericellular O2). However, it is discovered that physioxic (
Externí odkaz:
https://doaj.org/article/1068060eb74c48a59b7780c76e69d254
Autor:
Natalie S. Joe, Inês Godet, Nubaira Milki, Noor U. I. Ain, Harsh H. Oza, Gregory J. Riggins, Daniele M. Gilkes
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-18 (2022)
Abstract Breast cancer is the most diagnosed cancer among women. Approximately 15–20% of all breast cancers are highly invasive triple-negative breast cancer (TNBC) and lack estrogen, progesterone, and ERBB2 receptors. TNBC is challenging to treat
Externí odkaz:
https://doaj.org/article/7cb06462f9314d5ba5823989757985df
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Viperin, an IFN-regulated gene product, is known to inhibit fatty acid β-oxidation in the mitochondria, which enhances glycolysis and lipogenesis during viral infections. Yet, its role in altering the phenotype of cancer cells has not been establish
Externí odkaz:
https://doaj.org/article/14771bb6681940c4aff6e360e5b82e3d
Autor:
Natalie S. Joe, Christine Hodgdon, Lianne Kraemer, Kristin J. Redmond, Vered Stearns, Daniele M. Gilkes
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Breast cancer is the most commonly diagnosed cancer in women worldwide. Approximately one-tenth of all patients with advanced breast cancer develop brain metastases resulting in an overall survival rate of fewer than 2 years. The challenges
Externí odkaz:
https://doaj.org/article/d0a11b6843be427c9edb69242b62887d
Autor:
Heber L. Rocha, Inês Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul Macklin
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102935- (2021)
Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time. This approac
Externí odkaz:
https://doaj.org/article/5cae5965ce2a4feea68884bca732d613
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have
Externí odkaz:
https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b
Publikováno v:
Cells, Vol 11, Iss 4, p 686 (2022)
The rapid proliferation of cancer cells combined with deficient vessels cause regions of nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme hypoxic conditions and persist to promote cancer progression. Intratumo
Externí odkaz:
https://doaj.org/article/c4b49a748b9d4606be7d0748ac021559
Autor:
Hasini Jayatilaka, Pranay Tyle, Jonathan J. Chen, Minsuk Kwak, Julia Ju, Hyun Ji Kim, Jerry S. H. Lee, Pei-Hsun Wu, Daniele M. Gilkes, Rong Fan, Denis Wirtz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inh
Externí odkaz:
https://doaj.org/article/dbe0f12d5d9d4050b25725c41849802f
Autor:
Jenna M. Gilkes, Rebekah A. Frampton, Amanda J. Board, André O. Hudson, Thomas G. Price, Deborah L. Crittenden, Andrew C. Muscroft-Taylor, Campbell R. Sheen, Grant R. Smith, Renwick C.J. Dobson
The effect of population bottlenecks and genome reduction on enzyme function is poorly understood. ‘CandidatusLiberibacter solanacearum’ is a bacterium with a reduced genome that is transmitted vertically to the egg of an infected psyllid—a pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae563f9989df70e9064ff8f57b7f708
https://doi.org/10.1101/2023.04.17.537279
https://doi.org/10.1101/2023.04.17.537279
