Zobrazeno 1 - 10
of 703
pro vyhledávání: '"M. GEOGHEGAN"'
Autor:
Ravendra Garg, Kevin J. H. Allen, Wojciech Dawicki, Eileen M. Geoghegan, Dale L. Ludwig, Ekaterina Dadachova
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 1128-1140 (2021)
ABSTRACT Purpose Despite the availability of new drugs, many patients with acute myeloid leukemia (AML) do not achieve remission and outcomes remain poor. Venetoclax is a promising new therapy approved for use in combination with a hypomethylating ag
Externí odkaz:
https://doaj.org/article/af252bdb1a414e8c8cac047a8543fb55
Publikováno v:
Biochemistry and Biophysics Reports, Vol 21, Iss , Pp - (2020)
Molecular dynamics (MD) simulations were used to investigate the binding of four ligands to the Val122Ile mutant of the protein transthyretin. Dissociation, misfolding, and subsequent aggregation of mutated transthyretin proteins are associated with
Externí odkaz:
https://doaj.org/article/5791165ec5aa460f801c25f75b37ee4a
Autor:
Duncan R. Hewett, Kate Vandyke, David M. Lawrence, Natasha Friend, Jacqueline E. Noll, Joel M. Geoghegan, Peter I. Croucher, Andrew C.W. Zannettino
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 12, Pp 972-981 (2017)
Multiple myeloma (MM) is a hematological malignancy resulting from the uncontrolled proliferation of antibody-producing plasma cells in the bone marrow. At diagnosis, independent plasma cell tumors are found throughout the skeleton. The recirculation
Externí odkaz:
https://doaj.org/article/9891e1730b4e4a3a92cc6a87bb1595a4
Autor:
Eileen M. Geoghegan, Diana V. Pastrana, Rachel M. Schowalter, Upasana Ray, Wei Gao, Mitchell Ho, Gary T. Pauly, Dina M. Sigano, Campbell Kaynor, Ellen Cahir-McFarland, Benoit Combaluzier, Jan Grimm, Christopher B. Buck
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1169-1179 (2017)
Summary: Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of sial
Externí odkaz:
https://doaj.org/article/940b16d5a0d7411789fc82a19047a02f
Autor:
Mariano Prado Acosta, Eileen M. Geoghegan, Bernd Lepenies, Sandra Ruzal, Margaret Kielian, Maria Guadalupe Martinez
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Alphaviruses and flaviviruses are important human pathogens that include Chikungunya virus (CHIKV), Dengue virus (DENV), and Zika virus (ZIKV), which can cause diseases in humans ranging from arthralgia to hemorrhagic fevers and microcephaly. It was
Externí odkaz:
https://doaj.org/article/45c2f650fdbd43268a491dfe2f7d3bb0
Autor:
Kendra M. Dresback, Christine M. Szpilka, Xianwu Xue, Humberto Vergara, Naiyu Wang, Randall L. Kolar, Jia Xu, Kevin M. Geoghegan
Publikováno v:
Journal of Marine Science and Engineering, Vol 7, Iss 7, p 225 (2019)
With a growing population (over 40%) living in coastal counties within the U.S., there is an increasing risk that coastal communities will be significantly impacted by riverine/coastal flooding and high winds associated with tropical cyclones. Climat
Externí odkaz:
https://doaj.org/article/d05d3759474e4c13ab8023746d7e7411
Autor:
Dale Ludwig, Wojciech Dawicki, Ravendra Garg, Kevin J. H. Allen, Ekaterina Dadachova, Eileen M. Geoghegan
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 1128-1140 (2021)
Cancer Medicine
Cancer Medicine
Purpose Despite the availability of new drugs, many patients with acute myeloid leukemia (AML) do not achieve remission and outcomes remain poor. Venetoclax is a promising new therapy approved for use in combination with a hypomethylating agent or wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5b119488da6a01ebf186503bd8d291
https://doaj.org/article/af252bdb1a414e8c8cac047a8543fb55
https://doaj.org/article/af252bdb1a414e8c8cac047a8543fb55
Autor:
Malin D. Wijeratna, Eshan N.H. Oderuth, John M. Geoghegan, Paul Manning, Ben W. Gooding, Daniel L.J. Morris
Publikováno v:
Journal of Arthroscopy and Joint Surgery. 8:64-70
Background We report our medium-term outcomes of the balloon spacer in treating irreparable massive rotator cuff tears (MRCT). Methods Twenty-two patients (17 male:5 female; mean age 68.2 years) had a balloon spacer arthroscopically inserted between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d1af7e878749bd19ff8aca767baaf4e
https://doi.org/10.1016/j.jajs.2021.01.003
https://doi.org/10.1016/j.jajs.2021.01.003
Autor:
Christopher B Buck, Koenraad Van Doorslaer, Alberto Peretti, Eileen M Geoghegan, Michael J Tisza, Ping An, Joshua P Katz, James M Pipas, Alison A McBride, Alvin C Camus, Alexa J McDermott, Jennifer A Dill, Eric Delwart, Terry F F Ng, Kata Farkas, Charlotte Austin, Simona Kraberger, William Davison, Diana V Pastrana, Arvind Varsani
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005574 (2016)
Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches
Externí odkaz:
https://doaj.org/article/7739ad4591ff4b3b9ba8b0164dfb5663
Autor:
Ravendra Garg, Eileen M. Geoghegan, Wojciech Dawicki, Mark S. Berger, Dale L. Ludwig, Kevin J. H. Allen, Ekaterina Dadachova
Publikováno v:
Oncotarget
Chimeric antigen receptor (CAR) T cell therapies, and adoptive cell therapy (ACT) in general, represent one of the most promising anti-cancer strategies. Conditioning has been shown to improve the immune homeostatic environment to enable successful A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2ff8d673ede559fa00c72c7138e5a7
https://doi.org/10.18632/oncotarget.27731
https://doi.org/10.18632/oncotarget.27731