Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M. G. Willems"'
Autor:
E. M. M. van Bussel, N. H. M. Nguyen, A. I. Wierdsma, B. C. van Aken, I. E. M. G. Willems, C. L. Mulder
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Despite growing evidence for the role of attachment in psychosis, no quantitative review has yet been published on the relationship in this population between insecure attachment and recovery in a broad sense. We therefore used meta-analytic techniqu
Externí odkaz:
https://doaj.org/article/017647b4f89849fe9e31ee882aa16b90
Publikováno v:
Disability and Rehabilitation, 44(23), 7116-7126. Routledge/Taylor & Francis Group
Purpose To identify possible technological solutions that can contribute to stroke patients' participation at home. Methods In this qualitative case study, data on factors that negatively influenced participation at home were collected via semi-struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a92b1a8a6a7ebd153cad5fa7387c98
https://doi.org/10.1080/09638288.2021.1983041
https://doi.org/10.1080/09638288.2021.1983041
Autor:
Henriëtte M. G. Willems, Simon Edwards, Helen K. Boffey, Stephen J. Chawner, Christopher Green, Tamara Romero, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews
The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating cell signalling pathways and, as such, have become therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders. Many of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f8b2006fdb5bab4230b8704b380df0
Autor:
Timothy P. C. Rooney, Gregory G. Aldred, Helen K. Boffey, Henriëtte M. G. Willems, Simon Edwards, Stephen J. Chawner, Duncan E. Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews
Owing to their central role in regulating cell signaling pathways, the phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive therapeutic targets in diseases such as cancer, neurodegeneration, and immunological disorders. Until now, tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d160b7c900b0f29940d1fd8d175c7fc
Publikováno v:
Schizophrenia Bulletin Open. 4
Background Personal recovery has become a key objective in the treatment of clients with a psychotic disorder. So far it has been established that the two attachment dimensions, ie, anxious and avoidant, are negatively associated with subjective well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a98f93d1c4de96c2e40ec54af39c0a
https://doi.org/10.1093/schizbullopen/sgad010
https://doi.org/10.1093/schizbullopen/sgad010
Autor:
Jalal Ashayeri, R. M. G. Willems
Publikováno v:
Proceeding of Flexible Automation and Integrated Manufacturing 1996.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d67a7b05fbc68c95a2c2e06b63fb3d3e
https://doi.org/10.1615/faim1996.610
https://doi.org/10.1615/faim1996.610
Autor:
Caroline Richardson, Zining Wu, Henriëtte M. G. Willems, William E. Wixted, Alison Jo-Anne Woolford, Charlotte Mary Griffiths-Jones, Yolanda Sanchez, David Norton, Jeffrey K. Kerns, T.G. Davies, William G. Bonnette, Sharna J. Rich, James F. Callahan, Hong Nie, Lawrence Wolfe, Maria Grazia Carr, Marcel L. Verdonk, William L. Rumsey, Tom D. Heightman
Publikováno v:
Journal of Medicinal Chemistry. 64:15949-15972
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is increasing interest in developing small-molecule activators of this pathway as therapeutics for diseases involving chronic oxidative stress. The protein KEAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba196f8cf42319174247f8aba6d5c760
https://doi.org/10.1021/acs.jmedchem.1c01351
https://doi.org/10.1021/acs.jmedchem.1c01351
Autor:
John Skidmore, Jonathan H. Clarke, Elliott D. Bayle, Tashfina Mirza, Stephen P. Andrews, Henriëtte M. G. Willems, Duncan Scott, Timothy P. C. Rooney
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bifunctional molecules known as PROTACs simultaneously bind an E3 ligase and a protein of interest to direct ubiquitination and clearance of that protein, and they have emerged in the past decade as an exciting new paradigm in drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33edb481bdf8562badf0dddd3f1ab838
https://doi.org/10.1021/acsmedchemlett.0c00194
https://doi.org/10.1021/acsmedchemlett.0c00194
Autor:
Helen K. Boffey, Timothy P. C. Rooney, Henriette M. G. Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E. Scott, David Winpenny, James Duce, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews
Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing to their central role in regulating cell signaling pathways that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3436caf3f254cd663c0a8c1e1751a60
https://www.repository.cam.ac.uk/handle/1810/334446
https://www.repository.cam.ac.uk/handle/1810/334446
Autor:
Jennifer Turney, Henriëtte M. G. Willems, Philip J. Mitchell, Vivienne Allen, Alan G. Hendrick, Takashi Ito, Jenny Reeves, Susanne Wright, Ilka Müller, Richard J. Davenport, Richard Bazin, Stephen Wilkinson, Philip Leonard, Helen Heffron, Steve Irving
Publikováno v:
Journal of Medicinal Chemistry. 59:8094-8102
Fatty acid binding protein 6 (FABP6) is a potential drug discovery target, which, if inhibited, may have a therapeutic benefit for the treatment of diabetes. Currently, there are no published inhibitors of FABP6, and with the target believed to be am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb461ea8115897027e5a13fb8162307c
https://doi.org/10.1021/acs.jmedchem.6b00869
https://doi.org/10.1021/acs.jmedchem.6b00869