Zobrazeno 1 - 10
of 62
pro vyhledávání: '"M. G. WIENTJES"'
Advances in molecular medicine have led to identification of worthy cellular and molecular targets located in extracellular and intracellular compartments. Effectiveness of cancer therapeutics is limited in part by inadequate delivery and transport i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793396741f9fddac8263f090f28ce960
https://europepmc.org/articles/PMC4829347/
https://europepmc.org/articles/PMC4829347/
Publikováno v:
Cancer Chemotherapy and Pharmacology. 44:241-248
Purpose: We have previously shown that paclitaxel, when dissolved in water and instilled into the bladder, readily penetrates the urothelium. The FDA-approved formulation uses Cremophor and ethanol to dissolve paclitaxel. In the present study, the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5efd23bd8940692205c8631ef24f0e8
https://doi.org/10.1007/s002800050973
https://doi.org/10.1007/s002800050973
Publikováno v:
Pharmaceutical Research. 16:170-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d1749d8ed89607d86ca87024e08740
https://doi.org/10.1023/a:1011903719732
https://doi.org/10.1023/a:1011903719732
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:177-182
We have previously reported incomplete cytotoxic responses of other human solid tumors (bladder, head and neck, ovarian and prostate) to paclitaxel. This finding is qualitatively different from the nearly complete response observed in monolayer cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfccfef998c76899253ec0711228dd6
https://doi.org/10.1007/s002800050803
https://doi.org/10.1007/s002800050803
Publikováno v:
Pharmaceutical Research. 15:1760-1766
Purpose. We have shown that the three human prostate xenograft tumors, i.e. the androgen-dependent CWR22 tumor, and the androgen-resistant CWR22R and CWR91 tumors, are comparable to patient tumors in their expression of prostate specific antigen, mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdfe84dfaf73511cd36b274d1bffedc7
https://doi.org/10.1023/a:1011921031564
https://doi.org/10.1023/a:1011921031564
Publikováno v:
Cancer Chemotherapy and Pharmacology. 37:539-546
The bladder wall penetration kinetics of intravesical doxorubicin were examined in radical cystectomy patients, to provide insight into drug concentrations at target tumor sites. The dosing solution (40 mg/20 ml) was instilled just prior to the start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d024a7202d281d946648110d35c0b5aa
https://doi.org/10.1007/s002800050426
https://doi.org/10.1007/s002800050426
Publikováno v:
Pharmaceutical Research. 13:628-632
Purpose. This study examined the pharmacokinetic interaction between 2',3'-dideoxyinosine (ddl) and pentamidine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f473954dc7fc78303f2ff8e7b3ea33b6
https://doi.org/10.1023/a:1016018726327
https://doi.org/10.1023/a:1016018726327
Publikováno v:
Pharmaceutical Research. 13:1305-1312
Purpose. This study compared the sensitivity of rat prostate MAT-LyLu primary and lymph node metastatic tumors to taxol. Methods. Tumors were established by subcutaneous implantation of tumor cells in a hind leg (primary site) of male Copenhagen rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::491d6264902d256f0d844ba7d9e118bf
https://doi.org/10.1023/a:1016053412582
https://doi.org/10.1023/a:1016053412582
Publikováno v:
Pharmaceutical Research. 12:2012-2017
Purpose. To use the drug kinetics in dermis to predict the in vivo blood concentration after topical administration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::185efebd6ddc4f94ea1efdeadee21a57
https://doi.org/10.1023/a:1016268628647
https://doi.org/10.1023/a:1016268628647
Publikováno v:
Pharmaceutical Research. 12:108-112
The present study evaluated the kinetics of drug penetration in the dermis. A rat was given a dermal dose of 2',3'-dideoxyinosine (ddI). At 6 hr, the skin tissue was excised, immediately frozen and sectioned, and the decline of drug concentration as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1eadef0df36dd8add9d21565fb16265
https://doi.org/10.1023/a:1016298906589
https://doi.org/10.1023/a:1016298906589