Bioprinted Multi-Composition Array Mimicking Tumor Microenvironments to Evaluate Drug Efficacy with Multivariable Analysis.

Autor: Lee G; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea., Kim SJ; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea., Park JK; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.; KI for Health Science and Technology, KAIST Institutes (KI), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.; KI for Nanocentury, KAIST Institutes (KI), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (22), pp. e2303716. Date of Electronic Publication: 2024 Jun 14.

Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment

Autor: J. L.-S. Au, M. G. Wientjes, I. Knemeyer

Publikováno v: Cancer Chemotherapy and Pharmacology. 44:241-248

Purpose: We have previously shown that paclitaxel, when dissolved in water and instilled into the bladder, readily penetrates the urothelium. The FDA-approved formulation uses Cremophor and ethanol to dissolve paclitaxel. In the present study, the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5efd23bd8940692205c8631ef24f0e8
https://doi.org/10.1007/s002800050973

Cytostatic and apoptotic effects of paclitaxel in human breast tumors

Autor: Jie Lu, M. G. Wientjes, Yuebo Gan, Jessie L.-S. Au

Publikováno v: Cancer Chemotherapy and Pharmacology. 42:177-182

We have previously reported incomplete cytotoxic responses of other human solid tumors (bladder, head and neck, ovarian and prostate) to paclitaxel. This finding is qualitatively different from the nearly complete response observed in monolayer cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfccfef998c76899253ec0711228dd6
https://doi.org/10.1007/s002800050803

Pharmacologic effects of paclitaxel in human bladder tumors

Autor: Yuebo Gan, M. G. Wientjes, Jessie L.-S. Au, J. Kalns

Publikováno v: Cancer Chemotherapy and Pharmacology. 41:69-74

Purpose: The goal of this study was to determine whether paclitaxel, when given by a 2-h treatment, produces significant cytotoxic effects in human bladder transitional cell carcinoma and hence qualifies as a candidate drug for intravesical treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7451a0a507c291a64f1b56111169d35
https://doi.org/10.1007/s002800050709

Penetration of intravesical doxorubicin in human bladders

Autor: Robert A. Badalament, M. G. Wientjes, Jessie L.-S. Au

Publikováno v: Cancer Chemotherapy and Pharmacology. 37:539-546

The bladder wall penetration kinetics of intravesical doxorubicin were examined in radical cystectomy patients, to provide insight into drug concentrations at target tumor sites. The dosing solution (40 mg/20 ml) was instilled just prior to the start

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d024a7202d281d946648110d35c0b5aa
https://doi.org/10.1007/s002800050426