Výsledky vyhledávání - "M. G. Roncarolo"

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Autor: Jay M. Sosenko, D. J. Becker, Kevan C. Herold, E. Leschek, James W. Thomas, Francesco Dotta, Jeffrey L. Mahon, K. Nanto-Salonen, Diane K. Wherrett, Lisa M. Spain, Andrew Muir, Polly J. Bingley, Massimo Trucco, Jeffrey P. Krischer, S. E. Gitelman, Alessandra Mandelli, Mark S. Anderson, Sarah J. Richardson, Peter S. Linsley, Riccardo Bonfanti, Eleonora Bianconi, George S. Eisenbarth, M. Siegelman, J. Peyman, Angela Stabilini, M. Redondo, Bernhard J. Hering, Richard A. Insel, Maurizio De Pellegrin, Franco Meschi, Francesca Ragogna, Mark A. Clements, Lars Krogvold, Mark Peakman, Alberto Pugliese, J. Blum, William E. Russell, P. Chase, Pia Leete, Anette-Gabriele Ziegler, Mark A. Atkinson, Jane H. Buckner, Andrea Rigamonti, Tihamer Orban, Laura Nigi, Philip Raskin, Guido Sebastiani, Louis H. Philipson, Linda A. DiMeglio, Clara Bonura, Manuela Battaglia, Jay S. Skyler, David A. Baidal, Giulio Frontino, Emanuele Bosi, Matthew J. Dufort, Andrea Valle, William E. Winter, Peter A. Gottlieb, C. G. Fathman, Helena Elding Larsson, Robin Goland, Michael J. Clare-Salzler, M. G. Roncarolo, Raphael Clynes, Peter A. Antinozzi, Andrea K. Steck, Mikael Knip, Olli Simell, R. Parkman, Bart O. Roep, Desmond A. Schatz, Henry Rodriguez, Nicola Lo Buono, John M. Wentworth, Andrea Laurenzi, Francesca Mancarella, P. Savage, Jennifer B. Marks, G. Grave, Paola M.V. Rancoita, Federica Vecchio, Åke Lernmark, Darrell M. Wilson, Noel G. Morgan, Thomas W.H. Kay, Francine R. Kaufman, Federica Cugnata, Christophe Benoist, Susan Geyer, Peter G. Colman, Mark D. Pescovitz, Robert S. Sherwin, Gerald T. Nepom, John E. Wagner, Antoinette Moran, Knut Dahl-Jørgensen, Jerry P. Palmer, Kasia Bourcier, Wayne V. Moore, Carla J. Greenbaum, Pauline Grogan

BACKGROUND. Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee5d8b12a49d70a6a58dc2174c69799

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SAP and Lessons Learned from a Primary Immunodeficiency

Autor: J, Sayos, C, Wu, M, Morra, N, Wang, X, Zhang, D, Allen, S, van Schaik, L, Notarangelo, R, Geha, M G, Roncarolo, H, Oettgen, J E, De Vries, G, Aversa, C, Terhorst

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 199(5)

Approximately 19 years ago, Terhorst and colleagues ([1][1]) reported the cloning of the gene encoding a small adaptor protein, signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), named by virtue of its binding to the intracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888cb408fb2dd0051362ecfbde4dbe2e
https://pubmed.ncbi.nlm.nih.gov/28827385

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Genotypes and haplotypes in the 3′ untranslated region of the HLA-G gene and their association with clinical outcome of hematopoietic stem cell transplantation for beta-thalassemia

Publikováno v: Tissue Antigens. 79:326-332

Polymorphisms in the 3' untranslated region (3'UTR) of HLA-G, an important player in immunological tolerance, could be involved in post-transcriptional expression control, and their association with different clinical immune-related conditions includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1a460fe49a0c64add82b565d5b2308
https://doi.org/10.1111/j.1399-0039.2012.01862.x

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Akademický článek

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Progress and Prospects: Gene Therapy Clinical Trials (Part 2)

Publikováno v: Gene Therapy. 14:1555-1563

This is the second part of a review summarizing progress and prospects in gene therapy clinical research. Twenty key diseases/strategies are succinctly described and commented on by leaders in the field. This part includes clinical trials for skin di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afd401ec8bec5c238d348bc98e0aa46
https://doi.org/10.1038/sj.gt.3303033

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Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression

Autor: H Groux, T Sornasse, F Cottrez, J E de Vries, R L Coffman, M G Roncarolo, H Yssel

Publikováno v: The Journal of Immunology. 158:5627-5631

Differential expression of cytokine receptors accounts for an important regulatory mechanism in differentiation of Th1/Th2 subsets. Here, we report that human Th0 and Th2 clones constitutively express transcripts for the IFN-gammaR beta-chain, wherea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64f0c3b324ea0e1e81e4dec50a53aa3f
https://doi.org/10.4049/jimmunol.158.12.5627

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Unique cytokine production profile of anergic human T cells in SCID-hu mice after staphylococcal enterotoxin B administration

Autor: D Schols, D Jones, M G Roncarolo

Publikováno v: The Journal of Immunology. 154:3204-3212

Severe combined immunodeficient mice transplanted with human organs (SCID-hu mice), provide a unique in vivo model for studying human intrathymic T cell selection and development of tolerance. In vivo administration of staphylococcal enterotoxin B (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9636457486effa4b2bb9b8ac30097a71
https://doi.org/10.4049/jimmunol.154.7.3204

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