Lack of islet amyloid polypeptide/amylin-immunoreactivity in urine collected from healthy volunteers after ingestion of a carbohydrate-rich meal

Autor: Marinus A. Blankenstein, K. L. Van Hulst, Cornelis J.M. Lips, Jwm Hoppener, M. G. Nieuwenhuis

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 104:177-179

Islet amyloid polypeptide (IAPP), or amylin, is synthesized by beta cells in the islets of Langerhans of the pancreas. Plasma IAPP levels are highly elevated in patients with advanced renal failure. To investigate the involvement of the kidney in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92421f3489c86ec2590c63350618076c
https://doi.org/10.1055/s-0029-1211441

An improved method for the determination of islet amyloid polypeptide levels in plasma

Autor: B. C. Van Jaarsveld, Marinus A. Blankenstein, K. L. Van Hulst, M. G. Nieuwenhuis, Cornelis J.M. Lips, Jo W.M. Höppener, W. H. L. Hackeng

Publikováno v: Annals of Clinical Biochemistry, 31(2), 165-170. SAGE Publications Ltd
Scopus-Elsevier
Van Hulst, K L, Hackeng, W H L, Höppener, J W M, Van Jaarsveld, B C, Nieuwenhuis, M G, Blankenstein, M A & Lips, C J M 1994, ' An improved method for the determination of islet amyloid polypeptide levels in plasma ', Annals of Clinical Biochemistry, vol. 31, no. 2, pp. 165-170 . https://doi.org/10.1177/000456329403100209

SUMMARY. We describe an improved method for the determination of islet amyloid polypeptide (lAPP) levels in plasma. Plasma is first extracted with acid-acetone, followed by a specific and sensitive radioimmunoassay (RIA) for lAPP using rabbit­ anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c0e2f85a691d68348878a0cf65cbd5
https://doi.org/10.1177/000456329403100209

[Islet amyloid and diabetes mellitus type 2]

Autor: J W, Höppener, M G, Nieuwenhuis, T M, Vroom, C J, Lips

Publikováno v: Nederlands tijdschrift voor geneeskunde. 144(42)

Type 2 diabetes mellitus is a heterogeneous and multifactorial disorder accompanied by severe complications and a reduced life expectancy. Histopathologically, it is characterized by deposition of protein in the islets of Langerhans in the pancreas (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59ecfd013e7f331f2037ba9928236618
https://pubmed.ncbi.nlm.nih.gov/11072517

Multifocal fibrosclerosis presenting as Grave's orbitopathy. Bilateral exophthalmos associated with retroperitoneal and sellar fibrosis

Autor: R, van der Pol, M G, Nieuwenhuis, M P, Mourits

Publikováno v: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 237(3)

Multifocal fibrosclerosis (MF) is a rare disease that may be misdiagnosed as Graves' orbitopathy. The combination of localisations of MF presented here has not been reported before.A 44-year-old man was referred with progressive bilateral exophthalmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8515b680dbee491fb37980cd5609746f
https://pubmed.ncbi.nlm.nih.gov/10090590

A Comparative Study Between Human B-Cell Insulin and Islet Amyloid Polypeptide (IAPP) Storage and Amyloid Deposition in Type 2 Diabetes Mellitus and in Non-Diabetics

Autor: A. P. R. Blok, R. W. Veldhuizen, M. G. Nieuwenhuis, E. C. M. Ooms, M. J. H. Berends, C. J. M. Lips

Publikováno v: Amyloid and Amyloidosis 1990 ISBN: 9789401054508

Islet amyloid polypeptide is a recently discovered pancreatic polypeptide hormone which is produced by the B-cells of the islets of Langerhans and is co-secreted with insulin. IAPP is the formative protein in islet amyloid depositions in type-2 diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0d3716317884e5d867820df36797860
https://doi.org/10.1007/978-94-011-3284-8_114