Zobrazeno 1 - 10
of 95
pro vyhledávání: '"M. G. CHERIAN"'
Autor:
M G Cherian, Elena A. Ostrakhovitch
Publikováno v:
Apoptosis. 10:111-121
Previous studies revealed that cells may differ in their response to metal stress depending on their p53 status; however, the sequence of events leading to copper-induced apoptosis is still unclear. Exposure of copper (10 and 25 microM) and zinc (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875adbde8b6959f67cedee1836824afa
https://doi.org/10.1007/s10495-005-6066-7
https://doi.org/10.1007/s10495-005-6066-7
Autor:
Elena A. Ostrakhovitch, M G Cherian
Publikováno v:
Archives of Biochemistry and Biophysics. 423:351-361
Previous studies have suggested that cells may differ in their response to metal stress. This study was undertaken to investigate the role of PI3K/Akt signaling pathway in metal resistance in human breast cancer epithelial cells with different p53 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07e27ab5e8a122668317600e9af02aa
https://doi.org/10.1016/j.abb.2004.01.004
https://doi.org/10.1016/j.abb.2004.01.004
Autor:
L Z Fan, M G Cherian
Publikováno v:
British Journal of Cancer
The expression and induction of metallothionein has been associated with protection against oxidative stress and apoptosis. This study examines the effect of tumour suppressor protein p53 on metallothionein expression following CdCl2 treatment in eig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c9ae005a0d38b5e13e6770870eb8e6
https://doi.org/10.1038/sj.bjc.6600549
https://doi.org/10.1038/sj.bjc.6600549
Publikováno v:
Toxicological Sciences. 54:110-120
Prior studies show that a single subcutaneous (sc) exposure to cadmium (Cd) will induce injection site sarcomas (ISS) in rats. These tumors, thought clearly malignant, do not often metastasize or invade subdermal muscle layers because of their locati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179f39eb3c4a162bde997934d8755b2a
https://doi.org/10.1093/toxsci/54.1.110
https://doi.org/10.1093/toxsci/54.1.110
Autor:
M. G. Cherian, Yutaka Suzuki
Publikováno v:
Alcoholism: Clinical and Experimental Research. 24:315-321
Background: Three isoforms of metallothionein (MT-I, -II, and -III) have been detected in mice brain hut little is known on their inducibility. Therefore, changes in MT levels in brain were investigated in MT-I overexpressing transgenic mice (MT-I *
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ccb68b84f0b3c3bfd14209b2d094b63
https://doi.org/10.1111/j.1530-0277.2000.tb04613.x
https://doi.org/10.1111/j.1530-0277.2000.tb04613.x
Publikováno v:
Toxicology and Applied Pharmacology. 159:175-184
The changes in subcellular localization of metallothionein (MT) during differentiation were studied in two muscle cell lines, L6 and H9C2, myoblasts in order to understand the nuclear presence of MT and its antiapoptotic property. In myoblasts, MT an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d649884e2fda647cdff242e90fe5e00
https://doi.org/10.1006/taap.1999.8755
https://doi.org/10.1006/taap.1999.8755
Publikováno v:
Chemico-Biological Interactions. 115:141-151
Oxidative DNA damage can be caused by radicals generated by transitional metals like iron in Fenton reaction. Metallothionein (MT) may play an important role in preventing oxidative DNA damage. Therefore, after comparing the effects of ferric salts (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9946a03ec0426c9b892887e3fd9bb1d
https://doi.org/10.1016/s0009-2797(98)00069-6
https://doi.org/10.1016/s0009-2797(98)00069-6
Autor:
Shin-ichi Ono, M G Cherian
Publikováno v:
Biological Trace Element Research. 61:41-49
The developmental alterations in metallothionein (MT) proteins and zinc (Zn) were investigated in brains of two transgenic strains of mice. MT protein was measured by a cadmium binding assay and Zn by atomic absorption spectrophotometry. MT proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eed4ce128440157c8c21fa21f38d172
https://doi.org/10.1007/bf02784039
https://doi.org/10.1007/bf02784039
Autor:
C. D. Klaassen, M. G. Cherian, R. D. Palmiter, Michael Aschner, Ashley I. Bush, J. C. Erickson
Publikováno v:
Toxicology and Applied Pharmacology. 142:229-242
A symposium on the role of brain metallothioneins (MTs) in physiology and pathology was held at the 1996 Annual Society of Toxicology Meeting in Anaheim, California. The objectives of this symposium were to: (1) review the physiologic function of MTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dfd7b4b282aa2cba13bbb66a11f13d
https://doi.org/10.1006/taap.1996.8054
https://doi.org/10.1006/taap.1996.8054
Publikováno v:
Toxicological Sciences. 30:204-212
Inhaled CdCl2 is a pulmonary carcinogen in rats but not in mice. We hypothesized that pulmonary metallothionein (MT) induction may be different in both species and thereby may lead to different levels of protection from Cd-induced lung injury. Fisher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb080d23752a83221fe7388747584b93
https://doi.org/10.1093/toxsci/30.2.204
https://doi.org/10.1093/toxsci/30.2.204