Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc

Autor: Elena A. Ostrakhovitch, M G Cherian

Publikováno v: Archives of Biochemistry and Biophysics. 423:351-361

Previous studies have suggested that cells may differ in their response to metal stress. This study was undertaken to investigate the role of PI3K/Akt signaling pathway in metal resistance in human breast cancer epithelial cells with different p53 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07e27ab5e8a122668317600e9af02aa
https://doi.org/10.1016/j.abb.2004.01.004

Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53.

Autor: Kabir M; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hu X; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Martin TC; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Pokushalov D; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kim YJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chen Y; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Zhong Y; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Wu Q; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Chipuk JE; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shi Y; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Xiong Y; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Gu W; Institute for Cancer Genetics, and Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, 10032, USA., Parsons RE; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Jin J; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Dec 24, pp. e2413377. Date of Electronic Publication: 2024 Dec 24.

Repeated Cadmium Exposures Enhance the Malignant Progression of Ensuing Tumors in Rats

Autor: S Rehm, M G Cherian, Michael P. Waalkes

Publikováno v: Toxicological Sciences. 54:110-120

Prior studies show that a single subcutaneous (sc) exposure to cadmium (Cd) will induce injection site sarcomas (ISS) in rats. These tumors, thought clearly malignant, do not often metastasize or invade subdermal muscle layers because of their locati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179f39eb3c4a162bde997934d8755b2a
https://doi.org/10.1093/toxsci/54.1.110

Metallothionein and Apoptosis during Differentiation of Myoblasts to Myotubes: Protection against Free Radical Toxicity

Autor: Margarita D. Apostolova, M G Cherian, Iordanka A. Ivanova

Publikováno v: Toxicology and Applied Pharmacology. 159:175-184

The changes in subcellular localization of metallothionein (MT) during differentiation were studied in two muscle cell lines, L6 and H9C2, myoblasts in order to understand the nuclear presence of MT and its antiapoptotic property. In myoblasts, MT an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d649884e2fda647cdff242e90fe5e00
https://doi.org/10.1006/taap.1999.8755

Changes in brain metallothionein and Zinc during development in transgenic mice

Autor: Shin-ichi Ono, M G Cherian

Publikováno v: Biological Trace Element Research. 61:41-49

The developmental alterations in metallothionein (MT) proteins and zinc (Zn) were investigated in brains of two transgenic strains of mice. MT protein was measured by a cadmium binding assay and Zn by atomic absorption spectrophotometry. MT proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eed4ce128440157c8c21fa21f38d172
https://doi.org/10.1007/bf02784039