Zobrazeno 1 - 10
of 180
pro vyhledávání: '"M. G. CARON"'
Autor:
J D, Gross, D W, Kim, Y, Zhou, D, Jansen, L M, Slosky, N B, Clark, C R, Ray, X, Hu, N, Southall, A, Wang, X, Xu, E, Barnaeva, W C, Wetsel, M, Ferrer, J J, Marugan, M G, Caron, L S, Barak, K, Toth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(10)
SignificanceThe modulation of growth hormone secretagogue receptor-1a (GHSR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f838693fcac32b16a133b90127867a8a
https://pubmed.ncbi.nlm.nih.gov/35239443
https://pubmed.ncbi.nlm.nih.gov/35239443
Publikováno v:
Journal of Visualized Experiments.
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a crucial role in mediating cellular responses to cytokines and growth factors. STAT proteins are activated by tyrosine phosphorylation mediated ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79822018cdd16328865790da236c4cf0
https://doi.org/10.3791/62915
https://doi.org/10.3791/62915
Autor:
Chunhua Wang, Douglas S. Auld, M G Caron, William Adam Hill, Ji-Hu Zhang, Jaime Padrós, Zhaobin Kang, Debra Burdick
Publikováno v:
ASSAY and Drug Development Technologies. 10:179-186
Histone methylation is a regulated feature of nucleosomes that can have an impact on gene expression. The methylation state of histone residues has also been found in recent years to be associated with various disorders. Tools for detecting methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074ae68587b1ed6229448982ea3aa58b
https://doi.org/10.1089/adt.2011.0395
https://doi.org/10.1089/adt.2011.0395
Autor:
Ivan Izquierdo, Martín Cammarota, Bruno Leles, M. G. Caron, P Lima, Marcus Vinicius Gomez, Marco A. M. Prado, Raul R. Gainetdinov, Janine I. Rossato, Grace S. Pereira, Vania F. Prado, X. De Jaeger, V. Magalhães, B. M. de Castro, Cristina Martins-Silva
Publikováno v:
Genes, Brain and Behavior. 8:23-35
Storage of acetylcholine in synaptic vesicles plays a key role in maintaining cholinergic function. Here we used mice with a targeted mutation in the vesicular acetylcholine transporter (VAChT) gene that reduces transporter expression by 40% to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f84ca27e2c281bcb8cacbb95fb06fee
https://doi.org/10.1111/j.1601-183x.2008.00439.x
https://doi.org/10.1111/j.1601-183x.2008.00439.x
Autor:
Robert J. Lefkowitz, Richard T. Premont, Julia K. L. Walker, M G Caron, D.S. Feldman, John T. Fisher, Raul R. Gainetdinov, Peter K. McFawn
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L312-L319
G protein-coupled receptors (GPCRs) transduce extracellular signals into intracellular events. The waning responsiveness of GPCRs in the face of persistent agonist stimulation, or desensitization, is a necessary event that ensures physiological homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a073c9e274d516ef7b28202e3193aa63
https://doi.org/10.1152/ajplung.00255.2003
https://doi.org/10.1152/ajplung.00255.2003
Autor:
M M Sidor, S M Spencer, K Dzirasa, P K Parekh, K M Tye, M R Warden, R N Arey, J F Enwright, J P R Jacobsen, S Kumar, E M Remillard, M G Caron, K Deisseroth, C A McClung
Publikováno v:
Molecular Psychiatry. 20:1479-1480
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4380d9a9f08c44e171b78e8c81d13b6d
https://doi.org/10.1038/mp.2015.8
https://doi.org/10.1038/mp.2015.8
Publikováno v:
British journal of pharmacology. 170(5)
In addition to typical GPCR kinase (GRK)-/β-arrestin-dependent internalization, dopamine D3 receptor employed an additional GRK-independent sequestration pathway. In this study, we investigated the molecular mechanism of this novel sequestration pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25437157613ca13e06f9234554585620
https://pubmed.ncbi.nlm.nih.gov/23992580
https://pubmed.ncbi.nlm.nih.gov/23992580
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 74:1095-1110
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8efeda33d4248552be439af8c9b502bb
https://doi.org/10.1139/y96-124
https://doi.org/10.1139/y96-124
Autor:
M G Caron, Anja Rodenbrock, Lucille Beaudet, Claire Normand, Jaime Padrós, Nathalie Rouleau, Valérie Paquet, Nancy Gauthier, Anne Labonté, Mathieu Arcand, Roberto J. Rodriguez-suarez, Julie Blouin, Marjolaine Roy, Liliana Pedro
Publikováno v:
Journal of biomolecular screening. 17(1)
Histone posttranslational modifications are among the epigenetic mechanisms that modulate chromatin structure and gene transcription. Histone methylation and demethylation are dynamic processes controlled respectively by histone methyltransferases (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1daa88526b404b50d04edc38977f8f
https://pubmed.ncbi.nlm.nih.gov/21940714
https://pubmed.ncbi.nlm.nih.gov/21940714
Publikováno v:
Methods in molecular medicine. 62
One of the most valuable methods for understanding the function of a particular protein is the generation of animals that have had the gene encoding for the protein of interest disrupted, commonly known as a "quo;knockout"quo; or null mutant. By inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::987ef93eb6fb1834aefab72489491bba
https://pubmed.ncbi.nlm.nih.gov/21318776
https://pubmed.ncbi.nlm.nih.gov/21318776