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Akademický článek

Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients

Autor: Hilary E. Faust, MD, MTR, Oluwatosin Oniyide, BS, Yiyue Wang, BS, Caitlin M. Forker, BA, Thomas Dunn, BS, Wei Yang, PhD, Paul N. Lanken, MD, Carrie A. Sims, MD, PhD, Nadir Yehya, MD, MSCE, Jason D. Christie, MD, Nuala J. Meyer, MD, MTR, John P. Reilly, MD, MSCE, Nilam S. Mangalmurti, MD, Michael G. S. Shashaty, MD, MSCE

Publikováno v: Critical Care Explorations, Vol 4, Iss 4, p e0663 (2022)

OBJECTIVES:. Circulating nucleic acids, alone and in complex with histones as nucleosomes, have been proposed to link systemic inflammation and coagulation after trauma to acute kidney injury (AKI). We sought to determine the association of circulati

Externí odkaz: https://doaj.org/article/e3a67060f12a4c88988f1b6145e185cb

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Akademický článek

Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study

Autor: Michael G. S. Shashaty, John P. Reilly, Hilary E. Faust, Caitlin M. Forker, Caroline A. G. Ittner, Peggy X. Zhang, Meghan J. Hotz, David Fitzgerald, Wei Yang, Brian J. Anderson, Daniel N. Holena, Paul N. Lanken, Jason D. Christie, Nuala J. Meyer, Nilam S. Mangalmurti

Publikováno v: Critical Care, Vol 23, Iss 1, Pp 1-11 (2019)

Abstract Background Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothesized that plasma RIP

Externí odkaz: https://doaj.org/article/a664ae2ff997465080f3cc919233348c

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Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness

Autor: Viviane Khoury, D. Clark Files, Michael Bonk, Jessica A. Palakshappa, Caroline A. G. Ittner, David Fitzgerald, Michael G.S. Shashaty, John P. Reilly, Brian J. Anderson, Jason D. Christie, Kelly Butler, Caitlin M. Forker, Rui Feng, Nuala J. Meyer, William D. Schweickert

Publikováno v: Journal of Critical Care. 47:324-330

Purpose The objective of this study is to describe the relationship between two quantitative muscle ultrasound measures, the rectus femoris cross-sectional area (RF-CSA) and quadriceps muscle thickness, with volitional measures of strength and functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcbe07f09d454b850c30c70638b0f39
https://doi.org/10.1016/j.jcrc.2018.04.003

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Early Tacrolimus Concentrations After Lung Transplant are Predicted by Combined Clinical and Genetic Factors and Associated with Acute Kidney Injury

Autor: Joshua M. Diamond, Michelle Oyster, Mary Porteus, Michael G.S. Shashaty, M. Brown, Todd A. Miano, Laurel Kalman, Melanie Rushefski, Wei Yang, Jason D. Christie, Rui Feng, A. Russel Localio, Judd D. Flesch, Caitlin M. Forker, Edward Cantu

Publikováno v: Clin Pharmacol Ther

Tacrolimus exhibits unpredictable pharmacokinetics (PKs) after lung transplant, partly explained by cytochrome P450 (CYP)-enzyme polymorphisms. However, whether exposure variability during the immediate postoperative period affects outcomes is unknow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3842c0f898e06fa7357d51379eb4bb2e
https://europepmc.org/articles/PMC6980920/

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Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study

Autor: Daniel N. Holena, Caroline A. G. Ittner, David Fitzgerald, Meghan J. Hotz, Jason D. Christie, Peggy Zhang, Wei Yang, Paul N. Lanken, John P. Reilly, Nilam S. Mangalmurti, Hilary Faust, Michael G.S. Shashaty, Brian J. Anderson, Nuala J. Meyer, Caitlin M. Forker

Publikováno v: Critical Care
Critical Care, Vol 23, Iss 1, Pp 1-11 (2019)

Background Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothesized that plasma RIPK3 concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6f6a0f05b0e27d3e5d2b4266cadbec
http://europepmc.org/articles/PMC6599265

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The association of post-lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study

Autor: Jason D. Christie, Michelle Oyster, Joshua M. Diamond, Caitlin M. Forker, Edward E. Cantu, Mary K. Porteous, Qufei Wu, Todd A. Miano, Wei Yang, Michael G.S. Shashaty

Publikováno v: Clin Transplant

Background Prior studies of post-lung transplant acute kidney injury (AKI) have not accounted for confounding effects of primary graft dysfunction (PGD). We sought to test the impact of PGD on AKI risk factors and on the association of AKI with morta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa3197fc09b905d1c963a9d48712899
https://pubmed.ncbi.nlm.nih.gov/31355953

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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients

Autor: Nuala J. Meyer, Hilary Faust, Caitlyn M. Forker, Nilam S. Mangalmurti, Paul N. Lanken, Caroline A. G. Ittner, Jason D. Christie, Michael G.S. Shashaty, Brian J. Anderson, Benjamin A. Weaver, John P. Reilly, Daniel N. Holena, Peggy Zhang

Publikováno v: Chest

Background Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical illness causes endothelial dysfunction and lung injury in experimental models. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8e9441386ef123b9112a33e9d2808a
https://pubmed.ncbi.nlm.nih.gov/31622590

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Postreperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation

Autor: Jason D. Christie, Joshua M. Diamond, Caitlin M. Forker, Edward E. Cantu, Michael G.S. Shashaty, John P. Reilly, Lorraine B. Ware, Todd A. Miano, Michelle Oyster, Mary K. Porteous

Publikováno v: Am J Transplant

Acute kidney injury (AKI) is common after lung transplantation, but molecular markers remain poorly studied. The endothelial activation markers soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are implicated in k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25627d844dbad13ed872e19860f3e14a
https://pubmed.ncbi.nlm.nih.gov/31017370

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