Tandem metalloenzymes gate plant cell entry by pathogenic fungi

Autor: Bastien Bissaro, Sayo Kodama, Takumi Nishiuchi, Anna Maria Díaz-Rovira, Hayat Hage, David Ribeaucourt, Mireille Haon, Sacha Grisel, A. Jalila Simaan, Fred Beisson, Stephanie M. Forget, Harry Brumer, Marie-Noëlle Rosso, Victor Guallar, Richard O’Connell, Mickaël Lafond, Yasuyuki Kubo, Jean-Guy Berrin

Publikováno v: Science Advances
Science Advances, 2022, 8 (51), ⟨10.1126/sciadv.ade9982⟩

Global food security is endangered by fungal phytopathogens causing devastating crop production losses. Many of these pathogens use specialized appressoria cells to puncture plant cuticles. Here, we unveil a pair of alcohol oxidase–peroxidase enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1c8f1036eaddd3ee43ca110ca7a398
https://hal.inrae.fr/hal-03918339/document

On the Catalytic Activity of a GT1 Family Glycosyltransferase from Streptomyces venezuelae ISP5230

Autor: Stephanie M. Forget, Sydney B Shepard, Ebrahim Soleimani, David L. Jakeman

Publikováno v: The Journal of Organic Chemistry. 84:11482-11492

GT1 family glycosyltansferase, Sv0189, from Streptomyces venezuelae ISP5230 (ATCC 10721) was characterized. The recombinantly produced protein Sv0189 possessed UDP-glycosyltransferase activity. Screening, using an assay employing unnatural nitropheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04b8f5adf710de439354e095f1307c2f
https://doi.org/10.1021/acs.joc.9b01130

Discovery of a Fungal Copper Radical Oxidase with High Catalytic Efficiency toward 5-Hydroxymethylfurfural and Benzyl Alcohols for Bioprocessing

Autor: Alexander Holm Viborg, Wendy A. Offen, Bernard Henrissat, Yann Mathieu, Luisa Ciano, Gideon J. Davies, Harry Brumer, Stephanie M. Forget, Paul H. Walton, Elena Blagova

Publikováno v: ACS Catalysis
ACS Catalysis, American Chemical Society, 2020, 10 (5), pp.3042-3058. ⟨10.1021/acscatal.9b04727⟩
ACS Catalysis, 2020, 10 (5), pp.3042-3058. ⟨10.1021/acscatal.9b04727⟩

International audience; Alternatives to petroleum-based chemicals are highly sought-after for ongoing efforts to reduce the damaging effects of human activity on the environment. Copper radical oxidases from Auxiliary Activity Family 5/Subfamily 2 (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c95f3436707908e18649cb5430e8a00
https://hal-amu.archives-ouvertes.fr/hal-03162761

The expansive library of jadomycins

Autor: Jeanna M. MacLeod, David L. Jakeman, Stephanie M. Forget

Publikováno v: Canadian Journal of Chemistry. 96:495-501

The jadomycin family of natural products was discovered from Streptomyces venezuelae ISP5230 in the 1990s. Subsequent identification of the biosynthetic gene cluster along with synthetic efforts established that incorporation of an amino acid into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3957d2fe709d102139f260fb387a953b
https://doi.org/10.1139/cjc-2017-0573

Post Polyketide Synthase Carbon–Carbon Bond Formation in Type-II PKS-Derived Natural Products from Streptomyces venezuelae

Autor: Leah G. Bennett, David L. Jakeman, Hebelin Correa, Kerry B. Goralski, Jeanna M. MacLeod, Steven R. Hall, Russell G. Kerr, Stephanie M. Forget, Andrew W. Robertson, Logan W. MacIntyre

Publikováno v: The Journal of Organic Chemistry. 83:1876-1890

Polyketide synthase (PKS) derived natural products are biosynthesized by head-to-tail addition of acetate and malonate extender units resulting in linear extended-polyketide chains. Despite the well-documented structural diversity associated with PKS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34673c611f63401b2a7fb5cfe55e86a
https://doi.org/10.1021/acs.joc.7b02823