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Akademický článek

A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy

Autor: Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, Cliff J. Luke, Gary A. Silverman, Stephen C. Pak

Publikováno v: Autophagy Reports, Vol 3, Iss 1 (2024)

Autophagy is important for many physiological processes; and disordered autophagy can contribute to the pathogenesis of a broad range of systemic disorders. C. elegans is a useful model organism for studying the genetics of autophagy, however, curren

Externí odkaz: https://doaj.org/article/50031cc4024141b38ff18745781f19c2

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Akademický článek

LAIR-1 agonism as a therapy for acute myeloid leukemia

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)

Effective eradication of leukemic stem cells (LSCs) remains the greatest challenge in treating acute myeloid leukemia (AML). The immune receptor LAIR-1 has been shown to regulate LSC survival; however, the therapeutic potential of this pathway remain

Externí odkaz: https://doaj.org/article/4400206aba4d473a88839c90e119c65a

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Akademický článek

Testing the detection of large, secretive snakes using camera traps

Autor: Danielle K. Walkup, Wade A. Ryberg, Josh B. Pierce, Emlyn Smith, James Childress, Forrest East, Brian L. Pierce, Price Brown, Corey M. Fielder, Toby J. Hibbitts

Publikováno v: Wildlife Society Bulletin, Vol 47, Iss 1, Pp n/a-n/a (2023)

Abstract Novel technologies, such as camera traps, have expanded the opportunities for species detection, especially for rare species. Corresponding changes in data processing must occur to handle the large volume of data gathered from technology lik

Externí odkaz: https://doaj.org/article/42606b71a70c4972a9a9d5c72c563cf3

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Akademický článek

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Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay

Autor: Sara M. Fielder, Jill A. Rosenfeld, Lindsay C. Burrage, Lisa Emrick, Seema Lalani, Ruben Attali, Joshua N. Bembenek, Hieu Hoang, Dustin Baldridge, Gary A. Silverman, Tim Schedl, Stephen C. Pak

Publikováno v: Mol Genet Metab

We describe a proband evaluated through the Undiagnosed Diseases Network (UDN) who presented with microcephaly, developmental delay, and refractory epilepsy with a de novo p.Ala47Thr missense variant in the protein phosphatase gene, PPP5C. This gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5d7fdbb1ad9d65f3179720a07aad2b
https://doi.org/10.1016/j.ymgme.2022.03.007

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A motor independent requirement for dynein light chain in Caenorhabditis elegans meiotic synapsis

Autor: Sara M Fielder, William G. Kelly, Huiping Ling, Elizabeth J. Gleason, Tori Kent

Publikováno v: Genetics

The dynein motor complex is thought to aid in homolog pairing in many organisms by moving chromosomes within the nuclear periphery to promote and test homologous interactions. This precedes synaptonemal complex (SC) formation during homolog synapsis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe3fcabbf1079b30d5272445387cc44
https://pubmed.ncbi.nlm.nih.gov/34788833

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