Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M. Fayez Aziz"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract The structures and functions of proteins are embedded into the loop scaffolds of structural domains. Their origin and evolution remain mysterious. Here, we use a novel graph-theoretical approach to describe how modular and non-modular loop p
Externí odkaz:
https://doaj.org/article/211d9ce37a8d49bb918f751dce00ce01
Autor:
M. Fayez Aziz, Gustavo Caetano-Anollés
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Domains are the structural, functional and evolutionary units of proteins. They combine to form multidomain proteins. The evolutionary history of this molecular combinatorics has been studied with phylogenomic methods. Here, we construct net
Externí odkaz:
https://doaj.org/article/5e3ea5d14cda4503a3a348ecdbd00710
Autor:
Gustavo Caetano-Anollés, M. Fayez Aziz, Fizza Mughal, Ibrahim Koç, Kelsey Caetano-Anollés, Derek Caetano-Anollés
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 4, p 128 (2022)
Recruitment is a pervasive activity of life that is at the center of novelty generation and persistence. Without recruitment, novelties cannot spread and biological systems cannot maintain identity through time. Here we explore the problem of identit
Externí odkaz:
https://doaj.org/article/28d03181ceb64b21844eba526088571d
Autor:
Gustavo Caetano-Anollés, M Fayez Aziz, Fizza Mughal, Frauke Gräter, Ibrahim Koç, Kelsey Caetano-Anollés, Derek Caetano-Anollés
Publikováno v:
Evolutionary Bioinformatics, Vol 15 (2019)
Networks describe how parts associate with each other to form integrated systems which often have modular and hierarchical structure. In biology, network growth involves two processes, one that unifies and the other that diversifies. Here, we propose
Externí odkaz:
https://doaj.org/article/d7fb2d3441494a748df4f0c994e43007
Tracing protein and proteome history with chronologies and networks: folding recapitulates evolution
Publikováno v:
Expert Review of Proteomics. 18:863-880
Introduction While the origin and evolution of proteins remain mysterious, advances in evolutionary genomics and systems biology are facilitating the historical exploration of the structure, function and organization of proteins and proteomes. Molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cca7bf3e6b0bb5dd0333f77202142a
https://doi.org/10.1080/14789450.2021.1992277
https://doi.org/10.1080/14789450.2021.1992277
While the origin and early evolution of proteins and their biosynthetic mechanisms remain mysterious, advances in evolutionary genomics and systems biology are facilitating the historical exploration of the structure, function and organization of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af17358cff13cb8aa3370e99afffe1ea
https://doi.org/10.14293/s2199-1006.1.sor-.ppg9jlw.v1
https://doi.org/10.14293/s2199-1006.1.sor-.ppg9jlw.v1
Autor:
Derek Caetano-Anollés, Kelsey Caetano-Anollés, Ibrahim Koç, Fizza Mughal, M. Fayez Aziz, Gustavo Caetano-Anollés
Publikováno v:
Frontiers in bioscience (Landmark edition). 27(4)
Recruitment is a pervasive activity of life that is at the center of novelty generation and persistence. Without recruitment, novelties cannot spread and biological systems cannot maintain identity through time. Here we explore the problem of identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a009d7fd78e312b5f482327575bb96
https://pubmed.ncbi.nlm.nih.gov/35468687
https://pubmed.ncbi.nlm.nih.gov/35468687
Autor:
Gustavo Caetano-Anollés, M. Fayez Aziz
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Domains are the structural, functional and evolutionary units of proteins. They combine to form multidomain proteins. The evolutionary history of this molecular combinatorics has been studied with phylogenomic methods. Here, we construct networks of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7da58eab8a9e1638e033d42f1f336d
https://doi.org/10.1038/s41598-021-90498-8
https://doi.org/10.1038/s41598-021-90498-8
Autor:
Ibrahim Koc, Kelsey Caetano-Anolles, Derek Caetano-Anollés, Gustavo Caetano-Anollés, Fizza Mughal, Frauke Gräter, M. Fayez Aziz
Publikováno v:
Evolutionary Bioinformatics
Evolutionary Bioinformatics, Vol 15 (2019)
Evolutionary Bioinformatics, Vol 15 (2019)
Networks describe how parts associate with each other to form integrated systems which often have modular and hierarchical structure. In biology, network growth involves two processes, one that unifies and the other that diversifies. Here, we propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412adeeb37b2c541eea59a7446a9d7ea
https://doi.org/10.1177/1176934319872980
https://doi.org/10.1177/1176934319872980
Publikováno v:
Scientific Reports
The formation of protein structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dc08b46f6e3e09a339c0824ca32c99