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Synthesis and antinociceptive activity of [(2-oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones

Autor: M, Gökce, B, Cakir, K, Erol, M F, Sahin

Publikováno v: Archiv der Pharmazie. 334(8-9)

The synthesis and pharmacological evaluation of new [(2-oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones are reported. All compounds were screened for analgesic and antiinflammatory activities by using the AcOH induced-stretchin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3608b76969bcb43b0c4530e3831d88ad
https://pubmed.ncbi.nlm.nih.gov/11688138

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Synthesis and antinociceptive activity of (5-chloro-2-benzothiazolinon-3-yl)acetamide derivatives

Autor: T, Onkol, D S, Dogruer, S, Ito, M F, Sahin

Publikováno v: Archiv der Pharmazie. 333(10)

The synthesis of (5-chloro-2-benzothiazolinon-3-yl)acetamide derivatives is reported. The structure of these compounds is supported by their IR and 1H-NMR spectra. The compounds were tested for antinociceptive activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c239ddbb3337b091a6e6218143ff2402
https://pubmed.ncbi.nlm.nih.gov/11092136

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Studies on some 3(2H)-pyridazinone derivatives with antinociceptive activity

Autor: D S, Dogruer, M F, Sahin, S, Unlü, S, Ito

Publikováno v: Archiv der Pharmazie. 333(4)

Nineteen new [6-(4-methoxyphenyl)-3(2H)-pyridazinone-2-yl]-acetamide (1-10) and 3-[6-(4-methoxyphenyl)-3(2H)-pyridazin-one-2-yl]propanamide (11-19) derivatives have been synthesized in this study. The structures of the compounds have been elucidated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::047bc4d883483406b0d4100501058d62
https://pubmed.ncbi.nlm.nih.gov/10816899

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Hemicholinium-3 congeners as potential antagonists to organophosphate-induced toxicity

Autor: M. F. Sahin, Raj K. Bhatnagar, John P. Long, Jan R. Flynn, Joseph G. Cannon

Publikováno v: Journal of Medicinal Chemistry. 33:577-579

A series of congeners of hemicholinium-3, in which the 1,4-oxazinium rings of hemicholinium are replaced by pyrrolidine, piperidine, 1,3-dioxane, or 1,4-oxazine rings, is described. Several of the target compounds produced blockade of neuromuscular t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafdf934b65b39f4c82fb2a6460deb06
https://doi.org/10.1021/jm00164a017

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Prevention of organophosphate-induced toxicity in mice

Autor: U, Ozkutlu, J P, Long, J G, Cannon, M F, Sahin, C, Liang

Publikováno v: Archives internationales de pharmacodynamie et de therapie. 329(2)

bis-Quaternary amines, which are acetal analogues of hemicholinium-3, were synthesized and several compounds were potent chemicals to antagonize toxicity induced by the organophosphate, paraoxon. Structural requirements were specific and included two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec118049d424750f91796ca7c0ef5f44
https://pubmed.ncbi.nlm.nih.gov/8540771

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