Zobrazeno 1 - 10 of 67 pro vyhledávání: '"M. F. Powell"'
1
Long-term stability studies using radiopharmaceuticals: consequence of using multiply tritiated compounds, with an application to fluocinolone acetonide
Autor: M F, Powell, A, Magill, A R, Becker
Publikováno v: Pharmaceutical research. 3(6)
The use of multiply tritiated radiopharmaceutical compounds for long-term stability studies should be avoided because different radiolabeled products are produced by radioactive decay than by chemical degradation. This is demonstrated by showing that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08c3dea178d9867ffae53cbe8dc29831
https://pubmed.ncbi.nlm.nih.gov/24271836
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2
Solvent Isotope Effects in H2O−D2O Mixtures (Proton Inventories) on Serine-Protease-Catalyzed Hydrolysis Reactions. Influence of Oxyanion Hole Interactions and Medium Effects
Autor: James A. Wells, T. K. Chang, H.-X. Guo, A. J. Kresge, L. Mathew, Yvonne Chiang, M. F. Powell
Publikováno v: Journal of the American Chemical Society. 118:8802-8807
Rates of hydrolysis of succinyl-Ala-Ala-Pro-Phe-p-nitroanilide catalyzed by subtilisin and its N155G mutant were measured in H2O, D2O, and “HDO” (1:1 H2O:D2O). The solvent isotope effects (proton inventories) determined by these data showed no di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9a524bcb50f8cb0fb8b1a24903c4494
https://doi.org/10.1021/ja9614326
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3
HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions
Autor: A Sette, J Sidney, C Oseroff, M F del Guercio, S Southwood, T Arrhenius, M F Powell, S M Colón, F C Gaeta, H M Grey
Publikováno v: The Journal of Immunology. 151:3163-3170
In the present study, we describe the definition of a DRB1*0401 (DR4w4)-specific motif. The strategy used entailed a three-step process: 1) screening a large set of unrelated peptide ligands to identify good MHC binders; 2) truncation analysis of sev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad28a664ed801da027dc4864977da56
https://doi.org/10.4049/jimmunol.151.6.3163
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5
The use of peptide analogs with improved stability and MHC binding capacity to inhibit antigen presentation in vitro and in vivo
Autor: A G Lamont, M F Powell, S M Colón, C Miles, H M Grey, A Sette
Publikováno v: The Journal of Immunology. 144:2493-2498
The identification of a core region for OVA 323-339, which is critical in determining binding to IAd, has enabled us to generate a series of analog peptides in which this core region was extended at both the N and C termini with different amino acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26198cd2518e120585d69efe2b0aa07f
https://doi.org/10.4049/jimmunol.144.7.2493
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6
Rates of hydrogen exchange and kinetic isotope effects in the reaction ofp-nitrophenylnitromethane with amine bases in toluene solution: Absence of internal return
Autor: M. F. Powell, A. J. Kresge
Publikováno v: Journal of Physical Organic Chemistry. 3:55-61
Rates of loss of tritium from p-nitrophenylnitromethane-α-t in toluene solution catalyzed by a series of amine bases show that hydrogen exchange in this system occurs at the same rate as ionization of the carbon acid, and that internal return is not
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::341d079ee45c4ff15cc540e8c16694f5
https://doi.org/10.1002/poc.610030111
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7
Diabetic patient compliance as a function of counseling. 1979
Autor: M F, Powell, V D, Burkhart, P P, Lamy
Publikováno v: The Annals of pharmacotherapy. 40(4)
The impact of a specially designed patient education program upon the diabetes-related knowledge and compliance of insulin dependent diabetic patients was investigated. The program consisted of an audiovisual presentation, illustrated handout materia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e98a426e7e23ff695a40a5e3e0eca852
https://pubmed.ncbi.nlm.nih.gov/16569793
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9
Stability of alkoxycarbonylamidine prodrugs
Autor: Z, Shahrokh, E, Lee, A G, Olivero, R A, Matamoros, K D, Robarge, A, Lee, K J, Weise, B K, Blackburn, M F, Powell
Publikováno v: Pharmaceutical research. 15(3)
Alkoxycarbonylamidine prodrug modification was used to mask the positively-charged amidine moiety of an Arg-Gly-Asp peptidomimetic and enhance oral bioavailability. The aqueous stability of ethoxycarbonylamidine (ECA), ethanethiocarbonylamidine (ETCA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a77f2c24600371c1c45e658e9c7248b
https://pubmed.ncbi.nlm.nih.gov/9563074
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10
Drug delivery issues in vaccine development
Autor: M F, Powell
Publikováno v: Pharmaceutical research. 13(12)
Although significant headway has been made in vaccine development, there are several delivery-related issues that must be overcome to advance tomorrow's candidate vaccines. Some of these are in the areas of: single-shot subunit vaccines, therapeutic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98e773e04a17d17490595a878e334a3e
https://pubmed.ncbi.nlm.nih.gov/8987071
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