Výsledky vyhledávání - "M. F. Krummel"

Akademický článek

High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease

Autor: K. W. Im, L. A. Huppert, L. Malevanchik, H. S. Rugo, A. J. Combes, M. J. Campbell, M. F. Krummel, M. E. Melisko

Publikováno v: npj Breast Cancer, Vol 9, Iss 1, Pp 1-9 (2023)

Abstract Leptomeningeal disease (LMD) is a devastating complication of metastatic breast cancer (MBC). In this non-therapeutic study, we enrolled 12 patients with MBC and known or suspected LMD who were undergoing a lumbar puncture as part of clinica

Externí odkaz: https://doaj.org/article/9f6f8d8916c14e1abaf4fa234b9b3b05

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Akademický článek

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background Checkpoint blockade immunotherapy has improved metastatic cancer patient survival, but response rates remain low. There is an unmet need to identify mechanisms and tools to circumvent resistance. In human patients, responses to ch

Externí odkaz: https://doaj.org/article/4fe6933efb37461d998179c6fde2d077

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Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7

Autor: M F, Krummel, W R, Heath, J, Allison

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)

The role of second signals delivered through B7/CD28 interactions in T cell activation is well documented. However, once CTLs are elicited, TCR-mediated cytotoxicity appears to be uncoupled from the requirement for costimulatory signals. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe2135911badf4ca87649ffa0ebc8412
https://pubmed.ncbi.nlm.nih.gov/10477562

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The threshold for autoimmune T cell killing is influenced by B7-1

Autor: J, Allison, L A, Stephens, T W, Kay, C, Kurts, W R, Heath, J F, Miller, M F, Krummel

Publikováno v: European journal of immunology. 28(3)

The concept that naive CD4+ and CD8+ T cells require co-stimulatory signals for activation and proliferation is well documented. Less clear is the need for co-stimulation during the effector phase of the T cell response. Here we examined the influenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30229381fdd2f244ef42da2ca53874f5
https://pubmed.ncbi.nlm.nih.gov/9541590

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