Zobrazeno 1 - 10
of 36
pro vyhledávání: '"M. F. Grahn"'
Publikováno v:
Colorectal Disease. 6:308-319
Objective Fibrin glue has been used as a sphincter sparing approach for the treatment of anal fistulae for two decades. However, there is uncertainty about its short and long-term efficacy. The objective of this review was to ascertain the role of fi
Publikováno v:
Lasers in Surgery and Medicine. 27:235-240
Background and Objective Penetration of tissues by activating light ultimately limits the size of the lesions achievable in interstitial photodynamic therapy. Measurements of the wavelength-dependence of tissue optical properties suggest that substan
Autor:
Hans-Beat Ris, H. J. Altermatt, J. C. M. Stewart, A. McGuinness, M. L. De Jode, M. F. Grahn, A. Giger, Norman S. Williams
Publikováno v:
Lasers in Medical Science. 14:40-46
The in vivo photodynamic activities of four poly(ethylene glycol) (PEG) conjugates of the photosensitiser 5,10,15,20-tetrakis-(m-hydroxyphenyl)chlorin (mTHPC, temoporfin, Foscan(®)) were compared with that of mTHPC over a range of drug-light interva
Autor:
Anita McGuinness, Michael G. Dilkes, Norman S. Williams, Rachael Boyle, Babar Abbas, Robin Benzie, M. F. Grahn, Martin L. de Jode
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 37:261-266
The bacteriochlorin photosensitizer 5,10,15,20-tetrakis (m-hydroxyphenyl) bacteriochlorin (mTHPBC) is a member of a series of related compounds which includes the well-known compound 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin(mTHPC) (temoporfin). Al
Publikováno v:
Photochemistry and Photobiology. 63:885-891
The biodistribution and excretion of temoporfin (tetra[m-hydroxyphenyl]chlorin, m-THPC), a recently developed photosensitizer, was investigated in BALB/c mice. [14C]temoporfin was administered intravenously (0.73 mumol/kg) to tumor-free mice or to mi
Publikováno v:
Photochemistry and Photobiology. 61:397-401
— The biodistribution of temoporfin (tetra[m-hydroxyphenyl]chlorin, m-THPC), a recently developed photosensitizer, was investigated in BALB/c mice. The drug was administered intravenously (0.35-0.75 μmol/kg) to tumor-free mice or to mice implanted
Publikováno v:
Surgical Oncology. 3:1-10
The local recurrence rate of colorectal carcinoma after surgery is unacceptable in most series, and adjuvant therapies have made only a small impact on this. There is experimental evidence that adjuvant intraoperative photodynamic therapy (AIOPDT) ma
Publikováno v:
Lasers In Medical Science. 8:253-257
The design and application of an interstitial light delivery system suitable for photodynamic therapy of liver metastases is presented. The device incorporates an optical portion and a localization portion. Accurate geometric positioning of four 200
Publikováno v:
British Journal of Surgery. 80:115-120
The rectum and bladder share a common origin and work in harmony; disturbance in one may lead to a similar problem in the other. The two have, however, not previously been investigated dynamically and simultaneously. A new system has been devised all
Autor:
John J. Durcan, John D. Van Der Walt, Anita Griffith, Norman S. Williams, Adrian C. Rowland, M. F. Grahn, J. T. Allardice
Publikováno v:
Lasers in Medical Science. 7:133-142
A new adjunctive therapy is needed for colorectal carcinoma surgery to decrease local recurrence rates. Photodynamic therapy (PDT) may be able to fulfil this role by activating the selective photosensitizer haematoporphyrin derivative (HPD) intraoper