Zobrazeno 1 - 10
of 19
pro vyhledávání: '"M. Elizabeth Deerhake"'
Autor:
William E. Barclay, Nupur Aggarwal, M. Elizabeth Deerhake, Makoto Inoue, Toshiaki Nonaka, Kengo Nozaki, Nathan A. Luzum, Edward A. Miao, Mari L. Shinohara
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory
Externí odkaz:
https://doaj.org/article/9f2d7b3e62ca454686293fc58c6fcbd1
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophils are critical as the first-line defense against fungal pathogens. Yet, previous studies indicate that neutrophil function is complex during Cryptococcus neoformans (Cn) infection. To better understand the role of neutrophils in acute pulmo
Externí odkaz:
https://doaj.org/article/e2d515e9148343199027775011344aa7
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS
Externí odkaz:
https://doaj.org/article/562597864f864ccb8d4e580e0d1c1de9
Publikováno v:
Journal of leukocyte biology. 112(6)
Dectin-1 is known to drive proinflammatory cytokine production by macrophages and dendritic cells which promotes Th17 CD4+ T cell responses in the setting of fungal infection. However, the role of Dectin-1 signaling in neutrophils and its impact on C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe82f4bc667788466a49400606bcc28
https://pubmed.ncbi.nlm.nih.gov/36073780
https://pubmed.ncbi.nlm.nih.gov/36073780
Autor:
Makoto Inoue, Kengo Nozaki, Edward A. Miao, Mari L. Shinohara, Nupur Aggarwal, William E. Barclay, M. Elizabeth Deerhake, Toshiaki Nonaka, Nathan A. Luzum
Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740af11a1ddb5d2585167107a340fbb2
https://doi.org/10.1101/2021.10.03.462457
https://doi.org/10.1101/2021.10.03.462457
Publikováno v:
Trends Immunol
Dectin-1 is a C-type lectin receptor (CLR) expressed on the surface of various mammalian myeloid cells. Dectin-1 recognizes β-glucans and elicits antifungal proinflammatory immune responses. Recent studies have begun to examine the biology of Dectin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24615383adaabefae9e675ad5cafb66
https://pubmed.ncbi.nlm.nih.gov/34489167
https://pubmed.ncbi.nlm.nih.gov/34489167
Autor:
Shengjie Xu-Vanpala, Mari L. Shinohara, Maria Ciofani, Morgan E. Parker, M. Elizabeth Deerhake, Joshua D. Wheaton, Nancie J. MacIver, Praveen R. Juvvadi
Publikováno v:
Sci Immunol
Alveolar macrophages (AMs) are the major lung-resident macrophages and have contradictory functions. AMs maintain tolerance and tissue homeostasis, but they also initiate strong inflammatory responses. However, such opposing roles within the AM popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9130f4a28026ed7a584d7292cd4922f
https://doi.org/10.1126/sciimmunol.aba7350
https://doi.org/10.1126/sciimmunol.aba7350
Autor:
Mari L. Shinohara, William E. Barclay, Keiko Danzaki, Emre D. Cardakli, Nupur Aggarwal, Makoto Inoue, M. Elizabeth Deerhake, Toshiaki Nonaka, Ru-Rong Ji
Pathologic roles for innate immunity in neurologic disorders are well-described, but protective aspects of the immune response are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely known to induce inflammation. However, we found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87082ddc0db77d8c163f2181a8960e7
Autor:
Nupur Aggarwal, M. Elizabeth Deerhake, Devon DiPalma, Shailesh K. Shahi, Margaret R. Gaggioli, Ashutosh K. Mangalam, Mari L. Shinohara
Publikováno v:
Cell reports
SUMMARY Osteopontin (OPN) has been considered a potential biomarker of graft-versus-host disease (GVHD). However, the function of OPN in GVHD is still elusive. Using a mouse model of acute GVHD (aGVHD), we report that OPN generated by CD4+ T cells is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ac00facb337f05ffb641ffec1cae77
https://doi.org/10.1016/j.celrep.2021.110170
https://doi.org/10.1016/j.celrep.2021.110170
Publikováno v:
Immunity. 49:796-798
Researchers have previously hypothesized autoimmune origins for narcolepsy on the basis of its strong genetic association with an MHC class II allele. In a recent issue of Nature, Latorre et al. (2018) discovered that narcolepsy patients had autoreac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221cbf78ca9045538761392bd800b173
https://doi.org/10.1016/j.immuni.2018.11.002
https://doi.org/10.1016/j.immuni.2018.11.002