Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M. Eden Childs"'
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
Autor:
Sarah L'Heureux, Candice Romany, Olga Shestova, M. Eden Childs, Phyllis A. Gimotty, Lanwei Xu, Warren S. Pear, Mark Y. Chiang, Gavin Histen, Jon C. Aster
Publikováno v:
The Journal of clinical investigation. 118(9)
Gain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice, but it is unknown whether the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed0de3af19d392d6925b24f1e6baf07
https://pubmed.ncbi.nlm.nih.gov/18677410
https://pubmed.ncbi.nlm.nih.gov/18677410
Publikováno v:
Blood. 114:7-7
Abstract 7 Notch signaling is activated in ∼70% of human T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) samples and many human and mouse T-ALL cell lines require Notch signals for growth and survival. To gain insight into the role of Notch du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcc39185cb3bbb3470c4158c193330b
https://doi.org/10.1182/blood.v114.22.7.7
https://doi.org/10.1182/blood.v114.22.7.7
Publikováno v:
Blood. 114:395-395
Abstract 395 The Leukemia Stem Cell (LSC) hypothesis proposes that a subset of the cells in the bulk tumor cell population is responsible for leukemia maintenance and propagation. We tested the LSC hypothesis in murine T-cell acute lymphoblastic leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8d627449c8e3b54ac625f26ab431b1
https://doi.org/10.1182/blood.v114.22.395.395
https://doi.org/10.1182/blood.v114.22.395.395