Zobrazeno 1 - 10
of 49
pro vyhledávání: '"M. Ebron-McCoy"'
Publikováno v:
Reproductive Toxicology. 16:173-179
The acute phase response (APR) functions to reset metabolic homeostasis following infectious, toxic, or traumatic insult. TNF-α, a putative mediator of the APR, has been associated with fetal death in rodents and preterm labor and delivery in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1353943da55efb3de7d46edca4bdab1d
https://doi.org/10.1016/s0890-6238(02)00011-4
https://doi.org/10.1016/s0890-6238(02)00011-4
Publikováno v:
Teratology. 58:54-61
Acute human exposure to methanol (MeOH) results in elevated serum concentrations of both MeOH and formic acid. In order to better assess the risk of adverse developmental effects of MeOH exposure in humans, the effects of the combination of formate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50e85516196d9342a9045cb6dce055d
https://doi.org/10.1002/(sici)1096-9926(199808)58:2<54::aid-tera6>3.0.co
https://doi.org/10.1002/(sici)1096-9926(199808)58:2<54::aid-tera6>3.0.co
Publikováno v:
Teratology. 55:314-318
We previously reported the in vitro differential stereoselective dysmorphogenic potential of the R(+) and S(-) enantiomers of 2n-propyl-4-pentynoic acid (4-yn-VPA) in mice. To determine whether this stereoselectivity is species specific, we evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6f5e22c2289b95dc88fcef05101648
https://doi.org/10.1002/(sici)1096-9926(199705)55:5<314::aid-tera3>3.0.co
https://doi.org/10.1002/(sici)1096-9926(199705)55:5<314::aid-tera3>3.0.co
Publikováno v:
Teratology. 51:243-251
Acute methanol (MeOH) toxicity in primates is attributed to the conversion of MeOH to formate and the resulting acidosis. MeOH has been shown to be developmentally toxic in mice and rats both in vivo and in vitro, but rodents neither accumulate forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354d70b94e66cde67529e3c317a8f290
https://doi.org/10.1002/tera.1420510409
https://doi.org/10.1002/tera.1420510409
Publikováno v:
Toxicology. 97:159-171
Methanol induces developmental toxicity in rats and mice producing exencephaly, cleft palate, cervical skeletal defects, reduced body weight, and increased embryo/fetal death. Exposure to methanol in whole embryo culture also induces developmental re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4eeaa8be9404f4a2153790c136b501
https://doi.org/10.1016/0300-483x(94)02945-q
https://doi.org/10.1016/0300-483x(94)02945-q
Publikováno v:
Reproductive Toxicology. 8:405-410
Yolk-sacs from untreated Sprague-Dawley rat conceptuses were removed on gestational days (GD) 9 to 18 and examined for gamma-glutamyl transferase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDH), and glutamic-oxaloacetic transaminase (GO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ddb4404e253568f0a3632e1ccb299a
https://doi.org/10.1016/0890-6238(94)90080-9
https://doi.org/10.1016/0890-6238(94)90080-9
Publikováno v:
Toxicology and Applied Pharmacology. 126:260-266
Serum from procarbazine (PCZ)-treated rats is dysmorphogenic to rat embryos cultured in vitro, but PCZ is not effective when added directly to culture medium, even with an exogenous metabolizing system. Methylazoxyprocarbazine (MPCZ) is a metabolite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecddc91c8f5d4133f5a2beddc68226b
https://doi.org/10.1006/taap.1994.1115
https://doi.org/10.1006/taap.1994.1115
Publikováno v:
Toxicology in Vitro. 7:757-762
The effects of formate exposure on mammalian embryo development were investigated using the rat whole embryo culture system as a model. Day 9.5 (presomite) rat embryos were explanted and cultured for 48 hr in rotating bottles containing rat serum wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c2638c25b4998fbd0a8cca3109c0c3
https://doi.org/10.1016/0887-2333(93)90078-j
https://doi.org/10.1016/0887-2333(93)90078-j
Autor:
Leonard M. Mole, James E. Andrews, M. Ebron-McCoy, Robert J. Kavlock, Tina R. Logsdon, John M. Rogers
Publikováno v:
Toxicology. 81:205-215
Methanol (MeOH), a widely used industrial solvent, has been proposed as an alternative motor vehicle fuel. Inhaled MeOH is developmentally toxic in both rats and mice but the mouse is more sensitive than is the rat. The contribution of the embryo to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727e2bb208df493f5edd176e096dd531
https://doi.org/10.1016/0300-483x(93)90013-i
https://doi.org/10.1016/0300-483x(93)90013-i
Publikováno v:
Fundamental and Applied Toxicology. 18:288-293
Methyl 2-benzimidazolecarbamate (MBC) and its parent compound benomyl are used as agricultural fungicides. Both chemicals are embryotoxic if administered during organogenesis, and benomyl is teratogenic. Based on a previous study indicating a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da0bee7d24f610195546d06297c6db8c
https://doi.org/10.1016/0272-0590(92)90057-o
https://doi.org/10.1016/0272-0590(92)90057-o