Zobrazeno 1 - 10
of 42
pro vyhledávání: '"M. E. Wolff"'
Publikováno v:
Protein Engineering Design and Selection. 10:417-421
Basic fibroblast growth factor (bFGF) is implicated in the pathogenesis of several vascular and connective diseases. A key step in the discovery of bFGF receptor antagonists to mitigate these actions is to define the functional epitope required for r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c590bfa6decb8e57a46201a2dae763
https://doi.org/10.1093/protein/10.4.417
https://doi.org/10.1093/protein/10.4.417
Autor:
H, Zhu, K, Ramnarayan, J, Anchin, W Y, Miao, A, Sereno, L, Millman, J, Zheng, V N, Balaji, M E, Wolff
Publikováno v:
The Journal of biological chemistry. 270(37)
The importance of basic fibroblast growth factor (bFGF) in several pathophysiological processes has stimulated interest in the design of receptor antagonists to mitigate such effects. Of key importance in this connection is the characterization of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa34f884f5e8ca0b56472e926b7e3485
https://pubmed.ncbi.nlm.nih.gov/7665610
https://pubmed.ncbi.nlm.nih.gov/7665610
Publikováno v:
Biochemical and biophysical research communications. 201(1)
Novel endothelin antagonists were identified through a "pharmacophore directed screening" strategy. The sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00f959715a7820f064ae865198495c5
https://pubmed.ncbi.nlm.nih.gov/8198578
https://pubmed.ncbi.nlm.nih.gov/8198578
Autor:
M E, Wolff
Publikováno v:
NIDA research monograph. 134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e1addeb208ecdb9ce20af9ff02d48ee
https://pubmed.ncbi.nlm.nih.gov/8289885
https://pubmed.ncbi.nlm.nih.gov/8289885
Autor:
Alexander McPherson, M. E. Wolff
Publikováno v:
Nature. 345(6273)
By harnessing the remarkable power of the immune system to access the three-dimensional chemical information sequestered in target sites for drug ligands, antibody-directed drug discovery speeds the design of new therapeutic entities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3ca3dd6e1a4f9dbfe8ef4b735cf082
https://pubmed.ncbi.nlm.nih.gov/2342566
https://pubmed.ncbi.nlm.nih.gov/2342566
Publikováno v:
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 30:2516-2519
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9e2c58af0dc32b99342a5286381946
https://doi.org/10.1107/s0567740874007485
https://doi.org/10.1107/s0567740874007485
Publikováno v:
Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 31:292-295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d743577f968ddaeed8214d6b8ff310d
https://doi.org/10.1107/s0567740875002543
https://doi.org/10.1107/s0567740875002543
Publikováno v:
Chemischer Informationsdienst. 13
This communication shows that the apparent discrepancy of 0/sup 0/ to -46/sup 0/ for the value for tau (the C(16)-C(17)-C(20)-O(20) torsional angle) calculated from X-ray data and force-field calculations, is due to the use of an inadequate force-fie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9294b3c3d17303d2d2713fb9821fa0e
https://doi.org/10.1002/chin.198242068
https://doi.org/10.1002/chin.198242068
Autor:
M E, Wolff
Publikováno v:
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles. 282(1)
The nasolacrymal duct of Discoglossus pictus is able to differentiate in vitro from prometamorphosis, without thyroxine added to the culture medium if it is taken off late or with thyroxine added to the culture medium if it is taken off earlier (pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25f7cf2f549122f5686c738868c44277
https://pubmed.ncbi.nlm.nih.gov/816524
https://pubmed.ncbi.nlm.nih.gov/816524
Publikováno v:
Experientia Supplementum ISBN: 9783034857963
The nature of the relationship between chemical constitution and biological activity in steroids is of both practical and theoretical importance. Recently, we demonstrated that a given molecular modification in a steroid may exert its effect through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342c3d7910cf5d08df88f06691288225
https://doi.org/10.1007/978-3-0348-5795-6_3
https://doi.org/10.1007/978-3-0348-5795-6_3
