Výsledky vyhledávání

Variability of markers of inflammation and infection in induced sputum in children with cystic fibrosis

Autor: M. E. Wohl, Claudia L. Ordoñez, Alex Kartashov

Publikováno v: The Journal of Pediatrics. 145:689-692

To determine reproducibility of inflammatory marker concentrations in induced sputum from subjects with cystic fibrosis (CF), 15 nonexpectorating children, 6 to 13 years of age with mild CF lung disease, underwent 3 weekly sputum inductions with 3% s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed88515dd519e4f3a4a25f0a433e0a8
https://doi.org/10.1016/j.jpeds.2004.06.054

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Safety of repeated intermittent courses of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis

Autor: Henry L. Dorkin, David H. Christiansen, M. E. Wohl, Arnold L. Smith, Moira L. Aitken, Jay D. Eisenberg, Daniel V. Schidlow, Ivan R. Harwood, Bonnie W. Ramsey, Henry J. Fuchs, Robert W. Wilmott

Publikováno v: The Journal of Pediatrics. 131:118-124

Objectives: To determine the effect of repeated doses of aerosolized recombinant human deoxyribonuclease (rhDNase) on the development of anti-rhDNase antibodies, acute allergic reactions, and pulmonary function in patients with cystic fibrosis. Desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8813feced058e3b77dc450d82d07fef
https://doi.org/10.1016/s0022-3476(97)70134-3

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Standards and indications for cardiopulmonary sleep studies in children. American Thoracic Society

Autor: John L. Carroll, B. R. Maddern, D. C. Givan, Claude Gaultier, I. T. Nathanson, Debra E. Weese-Mayer, S. L. Davidson Ward, Carol L. Rosen, S. J. England, Gerald M. Loughlin, P. Ferber, Robert T. Brouillette, Gabriel G. Haddad, B. E. Chipps, M. E. Wohl, George B. Mallory, N. F. Ferraro, B. T. Thach, L. J. Brooke

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 153:866-878

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a51ae023acd4a1d4c432caf41cd1d5a
https://doi.org/10.1164/ajrccm.153.2.8564147

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Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

Autor: Clifford J. Rosen, Meryl S. LeBoff, Catherine M. Gordon, M. E. Wohl, Emanuela Binello, A. A. Colin

Publikováno v: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 17(5)

Patients with cystic fibrosis (CF) are known to be at risk for early osteoporosis, and the mechanisms that mediate bone loss are still being delineated. The aim of the present investigation was to investigate if a correlation exists in these patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec57309d5749be0c5537951d01f906d
https://pubmed.ncbi.nlm.nih.gov/16541207

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Epidemiologic study of cystic fibrosis: design and implementation of a prospective, multicenter, observational study of patients with cystic fibrosis in the U.S. and Canada

Autor: W J, Morgan, S M, Butler, C A, Johnson, A A, Colin, S C, FitzSimmons, D E, Geller, M W, Konstan, M J, Light, H R, Rabin, W E, Regelmann, D V, Schidlow, D C, Stokes, M E, Wohl, H, Kaplowitz, M M, Wyatt, S, Stryker

Publikováno v: Pediatric pulmonology. 28(4)

Cystic fibrosis (CF) is a complex illness characterized by chronic lung infection leading to deterioration in function and respiratory failure in over 85% of patients. An understanding of the risk factors for that progression and the interaction of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6dc4cf0b06e16408cae2dd144c548fb9
https://pubmed.ncbi.nlm.nih.gov/10497371

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Inhibition of neutrophil elastase in CF sputum by L-658,758

Autor: D D, Rees, J D, Brain, M E, Wohl, J L, Humes, R A, Mumford

Publikováno v: The Journal of pharmacology and experimental therapeutics. 283(3)

Elastases in cystic fibrosis (CF) pulmonary fluids damage lung tissue and perpetuate cycles of infection, inflammation and injury. Elastases from three different sources may be present in CF airways: neutrophils, macrophages and Pseudomonas. We measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4ffbc6560d119cf9f3eab03695e5803
https://pubmed.ncbi.nlm.nih.gov/9399994

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The effect of the absence of abdominal muscles on pulmonary function and exercise

Autor: M. E. Wohl, J. M. Ewig, N T Griscom

Publikováno v: American journal of respiratory and critical care medicine. 153(4 Pt 1)

In order to determine the long-term sequelae of prune belly syndrome (PBS) and whether the absence of abdominal wall musculature impairs exercise performance we studied nine patients 6 to 31 yr of age with PBS. Conventional spirometry, lung volumes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111e6122bff1a93d0656936bf517e037
https://pubmed.ncbi.nlm.nih.gov/8616560

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Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group

Autor: H J, Fuchs, D S, Borowitz, D H, Christiansen, E M, Morris, M L, Nash, B W, Ramsey, B J, Rosenstein, A L, Smith, M E, Wohl

Publikováno v: The New England journal of medicine. 331(10)

Respiratory disease in patients with cystic fibrosis is characterized by airway obstruction caused by the accumulation of thick, purulent secretions, which results in recurrent, symptomatic exacerbations. The viscoelasticity of the secretions can be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ade478e52c61520afca57a41bc1dbfca
https://pubmed.ncbi.nlm.nih.gov/8052279

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Efficacy and safety of short-term administration of aerosolized recombinant human deoxyribonuclease in patients with cystic fibrosis

Autor: Henry J. Fuchs, Arnold L. Smith, Daniel V. Schidlow, Ivan R. Harwood, Jay D. Eisenberg, Henry L. Dorkin, Steven Shak, Robert W. Wilmott, M. E. Wohl, Susan J. Astley, Bonnie W. Ramsey, Moira L. Aitken, Andrew A. Colin, Laura J. Meyerson, Ronald L. Gibson, Wylie Burke

Publikováno v: The American review of respiratory disease. 148(1)

Chronic endobronchial bacterial infection evokes purulent airway secretions in patients with CF. The viscoelastic properties of these secretions is primarily due to the presence of polymerized DNA from degenerating leukocytes. Recombinant human DNase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a252269dca12a3d72bef0a950d63e5
https://pubmed.ncbi.nlm.nih.gov/8317790

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Spinal fusion in Duchenne muscular dystrophy: a multidisciplinary approach

Autor: M. E. Wohl, Linda A. Specht, Navil F. Sethna, Steven D. Colan, Frederic Shapiro

Publikováno v: Musclenerve. 15(5)

We studied 27 Duchenne muscular dystrophy patients having spinal fusion for scoliosis. One patient died intraoperatively of cardiac arrest; all others have done well with no instances of malignant hyperthermia, postoperative ventilatory system depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b90a3a91f548a3bd5e5c717c9c4388c
https://pubmed.ncbi.nlm.nih.gov/1584253

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