Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M. E. Veronese"'
Autor:
J. A. Mazrimas, M. E. Veronese, Kenneth W. Turteltaub, M. H. Buonarati, James S. Felton, M. E. McManus, Mark G. Knize
Publikováno v:
Carcinogenesis. 11:941-946
The cytochrome P450-dependent metabolism of the heterocyclic amine mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) has been determined. We investigated the in vitro metabolism of PhIP by polycyclic hydrocarbon-induced mouse and rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3de63dcff041b68b1a4c2301514eb1
https://doi.org/10.1093/carcin/11.6.941
https://doi.org/10.1093/carcin/11.6.941
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(1)
The conversion of toluene and o-, m- and p-xylene to their respective side-chain and ring monohydroxylated metabolites by human liver microsomes was investigated. Methyl hydroxylation, to form a benzylalcohol, was the major metabolic pathway for all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6562ebe5456f130e693d96770ac1abfa
https://pubmed.ncbi.nlm.nih.gov/8558417
https://pubmed.ncbi.nlm.nih.gov/8558417
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(3)
Tolyl methylhydroxylation is the rate-limiting step in the elimination of torsemide, a newly developed diuretic, in humans in vivo. Kinetic and inhibitor studies with human liver microsomes and complementary DNA-expressed enzyme were performed to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd0a622a6170020cabd788fbb523ff6b
https://pubmed.ncbi.nlm.nih.gov/7891318
https://pubmed.ncbi.nlm.nih.gov/7891318
Autor:
W, Tassaneeyakul, D J, Birkett, M E, Veronese, M E, McManus, R H, Tukey, L C, Quattrochi, H V, Gelboin, J O, Miners
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(1)
Kinetic and inhibitor studies using cDNA-expressed enzymes and human liver microsomes have characterized the specificity of a range of cytochrome P450 (CYP) 1A substrate and inhibitor probes towards the two isoforms comprising this subfamily. Express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::682216fa9b3747ef6e4be8d8bc47d78d
https://pubmed.ncbi.nlm.nih.gov/8474022
https://pubmed.ncbi.nlm.nih.gov/8474022
Autor:
M. E. Veronese, Stuart McLean
Publikováno v:
European journal of clinical pharmacology. 40(5)
The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00472db399d1c9aa34342fb31b8251ea
https://pubmed.ncbi.nlm.nih.gov/1884730
https://pubmed.ncbi.nlm.nih.gov/1884730
Autor:
Stuart McLean, M. E. Veronese
Publikováno v:
European journal of clinical pharmacology. 40(6)
The metabolism of paracetamol and phenacetin has been studied in subjects previously phenotyped as either extensive or poor metabolisers of debrisoquine (EM and PM, respectively), in order to examine the relationship between phenacetin and paracetamo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9bbab956bd7c3f173bd904bb04482f
https://pubmed.ncbi.nlm.nih.gov/1884734
https://pubmed.ncbi.nlm.nih.gov/1884734
Publikováno v:
Cancer research. 50(11)
The human P-450 CYP1A1 gene and a P450IA2 complementary DNA have been expressed in Cos-1 cells and the expressed proteins were assayed for their capacity to metabolize the carcinogens 2-acetylaminofluorene (AAF), benzo(a)pyrene, 2-amino-3-methylimida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ab1730989e174aafd1534323a57de0c
https://pubmed.ncbi.nlm.nih.gov/2334931
https://pubmed.ncbi.nlm.nih.gov/2334931
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(3)
Tolbutamide hydroxylation has been investigated in human, rabbit and rat liver microsomes and by six purified forms of hepatic rabbit cytochromes P-450. These studies were carried out to investigate whether an appropriate animal model could be develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38b8c27b9ece0123e18d02b0ff203175
https://pubmed.ncbi.nlm.nih.gov/1974199
https://pubmed.ncbi.nlm.nih.gov/1974199
Autor:
M E, McManus, W M, Burgess, M E, Veronese, J S, Felton, M G, Knize, E G, Snyderwine, L C, Quattrochi, R H, Tukey
Publikováno v:
Progress in clinical and biological research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9088b75a9b6b7f01c9df75be178496cd
https://pubmed.ncbi.nlm.nih.gov/2392457
https://pubmed.ncbi.nlm.nih.gov/2392457
Publikováno v:
Biochemical pharmacology. 37(6)
Tolbutamide hydroxylation has been investigated in human liver microsomes. Anti-human liver NADPH-cytochrome P-450 reductase IgG inhibited hydroxytolbutamide formation and this metabolite was not formed when NADPH-generating system was omitted from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf08400520708b6ef0bc3994579cf979
https://pubmed.ncbi.nlm.nih.gov/3355588
https://pubmed.ncbi.nlm.nih.gov/3355588