Conversion of unresponsiveness to immune checkpoint inhibition by fecal microbiota transplantation in patients with metastatic melanoma: study protocol for a randomized phase Ib/IIa trial

Autor: J. S. W. Borgers, F. H. Burgers, E. M. Terveer, M. E. van Leerdam, C. M. Korse, R. Kessels, C. C. Flohil, C. U. Blank, T. N. Schumacher, M. van Dijk, J. G. E. Henderickx, J. J. Keller, H. W. Verspaget, E. J. Kuijper, J. B. A. G. Haanen

Publikováno v: BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)

Abstract Background The gut microbiome plays an important role in immune modulation. Specifically, presence or absence of certain gut bacterial taxa has been associated with better antitumor immune responses. Furthermore, in trials using fecal microb

Externí odkaz: https://doaj.org/article/6bd20975d8584eeab94f604ed9b0c810

Smoking status informs about the risk of advanced serrated polyps in a screening population

Autor: J. E. G. IJspeert, P. M. Bossuyt, E. J. Kuipers, I. Stegeman, T. R. de Wijkerslooth, E. M. Stoop, M. E. van Leerdam, E. Dekker

Publikováno v: Endoscopy International Open, Vol 04, Iss 01, Pp E73-E78 (2016)

Background and study aims: Evidence has accumulated that approximately 15 % to 30 % of colorectal cancers (CRC) arise from serrated polyps (SP). Population screening, therefore, should be designated to detect advanced SP, in addition to advanced aden

Externí odkaz: https://doaj.org/article/f6b0f945108843a59cbbf4b888dd5fba

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Autor: Andrés Cervantes, H.P. Knol, L. Østergaard, M.L. Lydrup, S.A. Radema, R.F. Schmitz, P. Nieboer, J. Hol, I. Edhemovic, K.C.M.J. Peeters, A. Johnsson, F.J.F. Jeurissen, Pieter J. Tanis, A.C.M. van de Luijtgaarden, P. Quarles an Ufford, H. Kim, Hein Putter, W.A. Bleeker, Tone Fokstuen, M E van Leerdam, K. Kovacs, A. Pronk, E.D. Kerver, L.G.H. Dewit, E. Garcia Granero, P.A. Nijenhuis, T. Fokstuen, S. Ottosson, P. Flygare, M.J. Safont, Iris D. Nagtegaal, F. Svendsen Jensen, C. Bratthäll, H.M. Ceha, L. Malmberg, P. Hede, W.M. van der Deure, G. Carlsson, J. Haux, Derk Jan A. de Groot, Esmée A Dijkstra, Renu R. Bahadoer, G.A.P. Nieuwenhuijzen, B. de Valk, B. Lindh, D. Hess, G.L. Beets, J.C. Bernal, A.M.E. Bruynzeel, R.M.P.H. Crolla, C. Kersten, P. Pfeiffer, S. Biondo, M.L. Silviera, Jannet C. Beukema, W.H. Schreurs, O. Hallböök, B.L. Lödén, A. Espí Macías, V. Velenik, L. Österlund, A. Slot, Geke A. P. Hospers, H. de Wilt, A.W.K.S. Marinelli, O. Lundberg, C. Radu, J. die Trill, I. Verbiené, P. Matthiessen, Mathijs P. Hendriks, J.H.M. Bekker, M. Walldén, V. Pachón, H.W. Kapiteijn, J.M. Immink, A. Piwowar, R. Salazar, L. Påhlman, P. Braam, K.E.J. Jensen, S. Festen, O. Mjåland, Elma Meershoek-Klein Kranenbarg, Jaume Capdevila, U. Palenius, K. Villmann, J.J. van der Vliet, Albert J. ten Tije, A. Berglund, Corrie A.M. Marijnen, G. Dafnis, J. Assarsson, J. Capdevila, J.W.T. Dekker, M. Grønlie Guren, G.J. Veldhuis, Q.A.J. Eijsbouts, G.J. Creemers, J.B. Tuynman, C.J.A. Punt, P.H.J.M. Veldman, J. Aparicio, Klaas Havenga, E.D. Geijsen, W.H. Steup, T. Rozema, K. Smedh, Lennart Blomqvist, J. de Boer, Cornelis J.H. van de Velde, S. Jangmalm, J.W.P. Vanstiphout, T.C. Stam, A.C.M. van den Bergh, Annet G H Roodvoets, Janet R. Vos, E.J.M. Siemerink, R.J.I. Bosker, Bengt Glimelius, A. Cervantes, E. Espin, Per Nilsson, A.J. Ten Tije, Ibrahim Edhemovic, Boudewijn van Etten, M. Tascilar, A.N. Nesbakken, G.A. Patijn, O. Reerink, Regina G. H. Beets-Tan, S. Skullman, H. Hörberg, P. Parinkh, G. Svaninger, M.B. Polée, D. Ten Bokkel Huinink, C. Hoff, A.F.T. Olieman, H. van den Berg, F.P. Peters, Torbjörn Holm, J.M. van Rooijen, M.P. Hendriks, J. Benedik, J.H. Svensson, A.L.T. Imholz

Publikováno v: Lancet Oncology, 22, 29-42
Lancet Oncology, 22(1), 29-42. ELSEVIER SCIENCE INC
the RAPIDO collaborative investigators 2021, ' Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial ', The Lancet Oncology, vol. 22, no. 1, pp. 29-42 . https://doi.org/10.1016/S1470-2045(20)30555-6
The Lancet Oncology, 22(1), 29-42. ELSEVIER SCIENCE INC
The Lancet. Oncology
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Lancet Oncology, 22, 1, pp. 29-42
The Lancet Oncology, 22(1), 29-42. ELSEVIER
The Lancet Oncology, 22(1), 29-42. Lancet Publishing Group
lancet oncology, 22(1), 29-42. Lancet Publishing Group

BACKGROUND: Systemic relapses remain a major problem in locally advanced rectal cancer. Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d055e24de581f7d953a2dafec480d7
https://doi.org/10.1016/s1470-2045(20)30555-6

Cutaneous squamous cell carcinoma is associated with Lynch syndrome: widening the spectrum of Lynch syndrome-associated tumours

Autor: Berbel L. M. Ykema, E. Dekker, M E van Leerdam, Marianne B. Crijns, Fonnet E. Bleeker, F. Adan, Petur Snaebjornsson, M. W. Bekkenk

Publikováno v: British journal of dermatology, 185(2), 462-463. Wiley-Blackwell

Dear Editor, Lynch syndrome (LS) is caused by a germline mutation in one of the mismatch repair (MMR) genes. Individuals with LS have an increased risk of developing colorectal and many other tumours including skin tumours.1 Sebaceous neoplasms and k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e898decfa42729b4e29ef57da8072d
https://pure.amc.nl/en/publications/cutaneous-squamous-cell-carcinoma-is-associated-with-lynch-syndrome-widening-the-spectrum-of-lynch-syndromeassociated-tumours(cbb6b450-c668-4662-a345-690f4f39413c).html

Adherence to Mismatch Repair Testing Guidelines in PT1 Colorectal Carcinomas Diagnosed Before the age of 70 Years

Autor: A. M. van Berkel, Berbel L. M. Ykema, T Dutch, M E van Leerdam, Iris D. Nagtegaal, Koert F. D. Kuhlmann

Publikováno v: ESGE Days 2021.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f342e7d4af1060b24b1f13056fa11e62
https://doi.org/10.1055/s-0041-1724337