Zobrazeno 1 - 8 of 8 pro vyhledávání: '"M. E. Van Dam"'
1
Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy
Autor: Martine J. Smit, Maikel Wijtmans, Cindy M. E. van Dam, Rob Leurs, Dennis Verzijl, Iwan J. P. de Esch, Leontien Bosch
Publikováno v: Wijtmans, M, Verzijl, D, van Dam, C M E, Bosch, L, Smit, M J, Leurs, R & de Esch, I J P 2009, ' Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy. ', Bioorganic and Medicinal Chemistry Letters, vol. 19, pp. 2252-7 . https://doi.org/10.1016/j.bmcl.2009.02.093
Bioorganic and Medicinal Chemistry Letters, 19, 2252-7. Elsevier Limited
A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d124e5846a2dc9047b98a23d3c85ec5
https://doi.org/10.1016/j.bmcl.2009.02.093
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2
Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists
Autor: Obbe P. Zuiderveld, Aldo Jongejan, Cindy M. E. van Dam, Frans J. J. de Kanter, Rob Leurs, Gabriella Coruzzi, Enade Perdana Istyastono, Rogier A. Smits, Iwan J. P. de Esch, Maristella Adami
Publikováno v: Smits, R A, Adami, M, Istyastono, E P, Zuiderveld, O P, Van Dam, C M, De Kanter, F J J, Jongejan, A, Coruzzi, G, Leurs, R & De Esch, I J 2010, ' Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists. ', Journal of Medicinal Chemistry, vol. 53, pp. 2390-2400 . https://doi.org/10.1021/jm901379s
Journal of Medicinal Chemistry, 53, 2390-2400. American Chemical Society
Hit optimization of the class of quinazoline containing histamine H(4) receptor (H(4)R) ligands resulted in a sulfonamide substituted analogue with high affinity for the H(4)R. This moiety leads to improved physicochemical properties and is believed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3596cabc02d3d37d3e531a890bc913e
https://research.vu.nl/en/publications/083d10d6-12d4-448a-9a16-961ae13559c2
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3
Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist
Autor: Herman D. Lim, Remko A. Bakker, Rob Leurs, Cindy M. E. van Dam, Rogier A. Smits, Iwan J. P. de Esch
Publikováno v: Lim, H D, Smits, R A, Bakker, R A, van Dam, C M E, de Esch, I J P & Leurs, R 2006, ' Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist ', Journal of Medicinal Chemistry, vol. 49, no. 23, pp. 6650-1 . https://doi.org/10.1021/jm060880d
Journal of Medicinal Chemistry, 49(23), 6650-1. American Chemical Society
During an in-house database screen, we identified S-(2-guanidylethyl)-isothiourea as a high affinity agonist for the histamine H4 receptor, with a 33-fold selectivity over the histamine H3 receptor and negligible affinity for the other histamine rece
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91ce052354e2d500135c0f2b5c3724d
https://research.vu.nl/en/publications/297d977a-0516-4fca-8086-c046ef52ea22
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4
Implicit memory tested in children during inhalation anaesthesia
Autor: M. E. Van Dam, F. M. E. Slijper, J. W. Van Kleff, Benno Bonke
Publikováno v: Anaesthesia. 47:747-749
Memory for stimuli presented during inhalation anaesthesia was tested in 80 children undergoing eye surgery. Two groups were exposed, in a random double-blind study, to repeated neutral phrases including either the colour orange or green. A postopera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181f37b2b83b22b4e0b9ab496152e6d8
https://doi.org/10.1111/j.1365-2044.1992.tb03251.x
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6
Metal affinity precipitation of proteins
Autor: M E, Van Dam, G E, Wuenschell, F H, Arnold
Publikováno v: Biotechnology and applied biochemistry. 11(5)
Proteins containing multiple surface-accessible histidine residues can be precipitated using small quantities of bis-copper chelates. The chelates serve to crosslink the proteins, presumably via the accessible histidines, leading to the formation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb23dcb5b8a5f00d213b3b63d69bf7e1
https://pubmed.ncbi.nlm.nih.gov/2508699
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