Výsledky vyhledávání - "M. E. Ressing"

Akademický článek

Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces

Autor: W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

Publikováno v: mAbs, Vol 16, Iss 1 (2024)

Antibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. Multiple strategies for viral epitope delivery

Externí odkaz: https://doaj.org/article/c04c265bd991403696916acc78b8076a

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Cellular immunity against DNA tumour viruses: possibilities for peptide-based vaccines and immune escape

Autor: C. J. M. Melief, René E. M. Toes, M. Hartman, Mariet C.W. Feltkamp, R. J. J. Blom, M. E. Ressing, R.M.P. Brandt, M. P. M. Vierboom, W. M. Kast, Rienk Offringa

Publikováno v: Scopus-Elsevier

Introduction The T-cell arm of the immune system plays an important role in the defence against viruses and virus-induced tumours [ 1,2]. Virus-induced tumours can be eradicated by both CD8' cytotoxic T-lymphocytes (CTLs) and CD4+ T-helper lymphocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f862abf202fd242e944161e860c17e
https://doi.org/10.1042/bst0230692

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Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides

Autor: M E Ressing, A Sette, R M Brandt, J Ruppert, P A Wentworth, M Hartman, C Oseroff, H M Grey, C J Melief, W M Kast

Publikováno v: The Journal of Immunology. 154:5934-5943

Human papillomavirus type 16 (HPV16) is strongly associated with cervical carcinogenesis. The HPV16 E6 and E7 oncoproteins are constitutively expressed in the majority of cervical tumor cells and are, therefore, attractive targets for CTL-mediated im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac91211f92de007975420378149695f1
https://doi.org/10.4049/jimmunol.154.11.5934

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CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells

Autor: M J Visseren, A van Elsas, E I van der Voort, M E Ressing, W M Kast, P I Schrier, C J Melief

Publikováno v: The Journal of Immunology. 154:3991-3998

CTL that lyse melanoma cells were previously isolated from several melanoma patients. Such CTL recognize autologous proteins, indicating the occurrence of autoreactive T cells in melanoma patients. We have now raised CTL, using responding T lymphocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc76e6c3e639aeaf4ca7718e6360cb9f
https://doi.org/10.4049/jimmunol.154.8.3991

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[Untitled]

Autor: C. W. Van Ingen, E. C. Beuvery, D.J.A. Crommelin, Herre Talsma, M. E. Ressing, Wim Jiskoot

Publikováno v: Pharmaceutical Research. :266-270

The influence of lyophilization on the stability of a monoclonal antibody (MN12) was investigated. MN12 was freeze-dried in different formulations [without lyoprotectant or in the presence of sucrose, dextran, or hydroxypropyl-beta-cyclodextrin (HP b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::592993b7f3908f2d536dccb0dc1489f7
https://doi.org/10.1023/a:1018905927544

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Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes

Autor: S H, van der Burg, M E, Ressing, K M, Kwappenberg, A, de Jong, K, Straathof, J, de Jong, A, Geluk, K E, van Meijgaarden, K L, Franken, T H, Ottenhoff, G J, Fleuren, G, Kenter, C J, Melief, R, Offringa

Publikováno v: International journal of cancer. 91(5)

Tumor-specific T-helper (Th) immunity was found to play a pivotal role in the natural and vaccine-induced immune defense against tumors. Since the majority of cervical cancers express human papillomavirus type 16 (HPV16) E7 oncoprotein, it is importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5e56cc920b06b6dbacdfd934d6cf013
https://pubmed.ncbi.nlm.nih.gov/11267969

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Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I-II trial

Autor: W.M. Kast, E.J.T. Krul, A. Tamm-Hermelink, Gert Jan Fleuren, P.A. van Dam, A.B. van Rossum, Rienk Offringa, Ed Schuuring, J.B. Trimbos, M. E. Ressing, R.M.P. Brandt, Cornelis J. M. Melief, Thomas Bauknecht, Gemma G. Kenter, W.J. van Driel

Publikováno v: European journal of cancer (Oxford, England, 35(6), 946-952. Elsevier Limited
European journal of cancer

A phase I-II clinical trial was performed involving vaccination with HPV16 E7 peptides of patients suffering from HPV16 positive cervical carcinoma which was refractory to conventional treatment. Patients receiving the vaccine were HLA-A(star)0201 po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9de31647dbec82b03416237a5949b1
https://pubmed.ncbi.nlm.nih.gov/10533477

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Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma

Autor: M E, Ressing, J H, de Jong, R M, Brandt, J W, Drijfhout, W E, Benckhuijsen, G M, Schreuder, R, Offringa, W M, Kast, C J, Melief

Publikováno v: European journal of immunology. 29(4)

Several cancer immune intervention protocols aim at inducing T cell immunity against antigens presented by HLA-A2, the most common human MHC class I molecule. In the context of HLA-A*0201, we previously identified two cytotoxic T lymphocyte epitopes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a778bf0c3aad72432cb66a68325896a1
https://pubmed.ncbi.nlm.nih.gov/10229097

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Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells

Autor: M L, De Bruijn, D H, Schuurhuis, M P, Vierboom, H, Vermeulen, K A, de Cock, M E, Ooms, M E, Ressing, M, Toebes, K L, Franken, J W, Drijfhout, T H, Ottenhoff, R, Offringa, C J, Melief

Publikováno v: Cancer research. 58(4)

Human papillomavirus (HPV) E6 and E7 oncoproteins are attractive targets for T-cell-based immunotherapy of cervical cancer. In this study, we demonstrate that dendritic cells (DCs) pulsed with HPV16 E7 protein are not only recognized in vitro by E7-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b452f3d293837bae7460f612ea7c454
https://pubmed.ncbi.nlm.nih.gov/9485027

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Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer

Autor: K, Kono, M E, Ressing, R M, Brandt, C J, Melief, R K, Potkul, B, Andersson, M, Petersson, W M, Kast, R, Kiessling

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(11)

An impaired immune response is frequently observed in patients and experimental animals with advanced cancer. We and others have shown alterations in CD3-associated signal-transducing zeta molecules in tumor-infiltrating T cells and peripheral blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65fe960cef5f5ff323d29b321e4a6bce
https://pubmed.ncbi.nlm.nih.gov/9816136

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