Výsledky vyhledávání

Transfer of a protein binding epitope to a minimal designed peptide

Autor: David Y. Jackson, H H Chiu, Susan M. Keating, Nicholas J. Skelton, M. E. Renz, Dean R. Artis, Cynthia P. Quan, Kevin R Clark, Maureen Beresini, Sherman Fong

Publikováno v: Biopolymers. 47:265-275

Results from protein mutagenesis and x-ray crystallographic studies of the multidomain protein Vascular Cell Adhesion Molecule (VCAM) were used to design cyclic octapeptides that retain the critical structural and binding elements of the epitope of V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72bb39ff6551186481948439be4fe3b9
https://doi.org/10.1002/(sici)1097-0282(1998)47:4<265::aid-bip2>3.0.co

Zobrazit plný text záznamu

Mucosal addressin cell adhesion molecule-1: a structural and functional analysis demarcates the integrin binding motif

Autor: J L Viney, S Jones, H H Chiu, B Lagrimas, M E Renz, L G Presta, D Jackson, K J Hillan, S Lew, S Fong

Publikováno v: The Journal of Immunology. 157:2488-2497

The leukocyte integrin receptor, alpha 4 beta 7, and the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are postulated to be important in regulating lymphocyte trafficking to normal intestine. Here we provide the first description of MAdCAM-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4252c93b5e89185ec3627525637c75a5
https://doi.org/10.4049/jimmunol.157.6.2488

Zobrazit plný text záznamu

Autor: H H Chiu, D T Crowe, M E Renz, L G Presta, S Jones, I L Weissman, S Fong

Publikováno v: The Journal of Immunology. 155:5257-5267

The integrin receptors alpha 4 beta 1 and alpha 4 beta 7 both bind to vascular cell adhesion molecule-1 (VCAM-1). Here, we report that the amino acid residue requirements for murine VCAM-1 adhesion to murine alpha 4 beta 1 (WEHI 231) and alpha 4 beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42687324ba51d05bd5a7f02df78d72aa
https://doi.org/10.4049/jimmunol.155.11.5257

Zobrazit plný text záznamu

Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to alpha 4 beta 1

Autor: M E Renz, J Fox, H H Chiu, L G Presta, Sherman Fong, K J Kim, S Jones

Publikováno v: The Journal of Cell Biology

This study describes the identification of seven amino acid residues of the vascular cell adhesion molecule (VCAM-1) that influence binding to the alpha 4 beta 1 receptor. Using recombinant murine VCAM-1-IgG, which is bound by both mouse (WEHI 231) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477a9dc501a22964c696bca6a275bd33
http://europepmc.org/articles/PMC2290915

Zobrazit plný text záznamu