Zobrazeno 1 - 10
of 26
pro vyhledávání: '"M. E. J. Billingham"'
Publikováno v:
Annals of the Rheumatic Diseases. 57:703-710
Hypothesis Persistent synovitis results from a hypoxia driven progressive transition to glycolytic metabolism that promotes transcriptional changes permissive to unresolved inflammation as the disease progresses. Erosion of cartilage and bone may inv
Publikováno v:
Arthritis & Rheumatism. 38:525-532
OBJECTIVE To determine whether chondrocytes in early experimental osteoarthritic (OA) cartilage continue to show increased synthesis and turnover of proteoglycans (PGs) during explant culture. A comparison was also made between the responsiveness of
Autor:
J. J. Nietfeld, A. J. Duits, G. Venn, M. E. J. Billingham, Elizabeth C. Arner, T. E. Hardingham, F. M. Brennan, M. Covington
Publikováno v:
Arthritis & Rheumatism. 36:819-826
Objective. To measure levels of cytokines, proteases, and glycosaminoglycans (GAG) in synovial fluid (SF) from the knees of animals with experimental osteoarthritis (OA) and from their contralateral (control) knees, and to compare and correlate these
Autor:
Graham N. Wishart, M. E. J. Billingham, Dell Colin Peter, Srinivasan Chandrasekhar, J. M. Bailey, Smith Colin William, Ann E. Kingston, Caroline A Hicks, Anita K. Harvey
Publikováno v:
ChemInform. 27
Publikováno v:
The Journal of Experimental Medicine
A recombinant (r)65-kD protein from Mycobacterium leprae, at levels far in excess of those present in whole mycobacteria, was unable to induce arthritis. Even when combined with a synthetic adjuvant, CP20961, to mimic the peptidoglycan adjuvant compo
Publikováno v:
Agents and Actions. 29:77-87
Monoclonal antibodies to certain cell surface constituents on lymphocytes, monocytes and macrophages have been administered to Lewis rats with developing, established or adoptively transferred arthritis, to determine any immunomodulatory properties.
Publikováno v:
Agents and Actions. 41:C198-C200
Cathepsin B is a lysosomal cysteine proteinase, thought to be involved in the degradation of connective tissue breakdown products internalized by endocytosis. It has also been implicated in the extracellular matrix degradation of collagens and proteo
Autor:
J. Koopdonk-Kool, S. C. R. Meacock, Rowena A.D. Bunning, M. H. M. Meijers, M. E. J. Billingham, C. J. F. Van Noorden
Publikováno v:
Agents and actions, 39(Spec No), C219-C221. Birkhauser Verlag Basel
Cathepsin B and L activity was studied histochemically in arthritic rat ankle joints using specific synthetic substrates in a post coupling method on unfixed and undecalcified cryostat sections of rat ankle joints. Activity was strongly increased in
SUMMARY The effects of a mycobacterial 71-kD hsp antigen have been investigated for its ability to modulate arthritis in rats. Subcutaneous injection (base of tail) of increasing amounts of hsp71 from Mycobacterium tuberculosis (MTB) produced dose-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45390d960269e23945467abc9beea27f
https://europepmc.org/articles/PMC2200306/
https://europepmc.org/articles/PMC2200306/
Publikováno v:
Annals of the rheumatic diseases. 53(10)
OBJECTIVES--The role of lymphocytes and macrophages in developing adjuvant arthritis induced by an injection of CP20961 in inbred Lewis rats was studied over a 32 day period using a novel biotin-avidin immunoperoxidase histochemical technique. METHOD