Zobrazeno 1 - 10
of 58
pro vyhledávání: '"M. E. Hughes"'
Autor:
Min Zhou, Jet Tsien, Ryan Dykstra, Jonathan M. E. Hughes, Byron K. Peters, Rohan R. Merchant, Osvaldo Gutierrez, Tian Qin
Publikováno v:
Nature Chemistry. 15:550-559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c25e5adc5e48fe671cf32ecbba01e7
https://doi.org/10.1038/s41557-023-01150-z
https://doi.org/10.1038/s41557-023-01150-z
Autor:
Chao Hu, Cuong Vo, Rohan R. Merchant, Si-Jie Chen, Jonathan M. E. Hughes, Byron K. Peters, Tian Qin
Publikováno v:
J Am Chem Soc
Heterocycles are the backbone of modern medical chemistry and drug development. The derivatization of "an olefin" inside aromatic rings represents an ideal approach to access functionalized saturated heterocycles from abundant aromatic building block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb786bc1df463228da2a87e6e6ebb65
https://doi.org/10.1021/jacs.2c11664
https://doi.org/10.1021/jacs.2c11664
Publikováno v:
Nature Chemistry. 13:950-955
Bicyclic hydrocarbons, and bicyclo[1.1.1]pentanes (BCPs) in particular, are playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical and materials chemistry. Taking advantage of strain-release strategies, prior synthetic stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34e12b451a3c008bd3651795bd4c16f
https://doi.org/10.1038/s41557-021-00786-z
https://doi.org/10.1038/s41557-021-00786-z
Autor:
Patrick J. Walsh, Anthony Ciro, Rohan R Merchant, Jonathan M E Hughes, Russell A. Shelp, Youge Pu
Publikováno v:
Chemical Science
We report a 3-component reaction between N-benzyl ketimines, [1.1.1]propellane, and pinacol boronates to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates. These structures are analogous to highly sought diarylmethanamine cores, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1363a793bc2f5f4f986c4b56193ce9ef
https://doi.org/10.1039/d1sc01349a
https://doi.org/10.1039/d1sc01349a
Publikováno v:
Journal of the American Chemical Society. 143:471-480
Alkyl boronic acids and esters play an important role in the synthesis of C(sp3)-rich medicines, agrochemicals, and material chemistry. This work describes a new type of transition-metal-free mediated transformation to enable the construction of C(sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ed37b1da5ef4c92926703be87787d0
https://doi.org/10.1021/jacs.0c11964
https://doi.org/10.1021/jacs.0c11964
Autor:
Álvaro Gutiérrez-Bonet, Stasik Popov, Marion H. Emmert, Jonathan M. E. Hughes, Andrew F. Nolting, Serge Ruccolo, Yunyi Wang
Publikováno v:
Organic letters. 24(19)
The cyclopropanation of alkenyl boronates and subsequent derivatization of the boronate handle are a convenient strategy to quickly build molecular complexity and access diverse compounds with a high sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1587aa63c088d55935199652ac3b145d
https://pubmed.ncbi.nlm.nih.gov/35544734
https://pubmed.ncbi.nlm.nih.gov/35544734
Autor:
Alexis L. Gabbey, Nicholas W. M. Michel, Jonathan M. E. Hughes, Louis-Charles Campeau, Sophie A. L. Rousseaux
Publikováno v:
Organic letters. 24(17)
The transition-metal-catalyzed α-arylation of secondary amides remains a synthetic challenge due to the presence of a free N-H bond. We report a strategy to synthesize secondary α-aryl amides via a Ni-catalyzed reductive arylation of redox-active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70045b3431ef3a47288e7b5bf57c188
https://pubmed.ncbi.nlm.nih.gov/35471845
https://pubmed.ncbi.nlm.nih.gov/35471845
Autor:
My Sam Mansueto, Brooke M Swalm, Patrick S. Fier, Rachel L. Palte, Sandra Lee, Kristin Geddes, Josep Saurí, Michael H. Reutershan, Charles S. Yeung, Benjamin Nicholson, David J. Witter, Murray Wan, Robert P Hayes, Haiyan Xu, David L. Sloman, Nicole Follmer, Daniel S. Spellman, Danica A. Rankic, Pierre Daublain, Timothy J. Henderson, Jongwon Lim, Dapeng Chen, Erik Munsell, Guo Feng, Steven M. Silverman, Ryan V Quiroz, Doug Linn, Sulagna Sanyal, Michelle R. Machacek, Craig R. Gibeau, Shuhei Kawamura, Yuanwei Gao, Jonathan M E Hughes, Sebastian Schneider, Phieng Siliphaivanh, Yingchun Ye, Brian M. Lacey
Publikováno v:
Journal of medicinal chemistry. 64(7)
Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyzes the post-translational symmetric dimethylation of protein substrates. PRMT5 plays a critical role in regulating biological processes including transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c9cca5e958fa221091b3803ef442cf
https://pubmed.ncbi.nlm.nih.gov/33755451
https://pubmed.ncbi.nlm.nih.gov/33755451
Bicyclic hydrocarbons, bicyclo[1.1.1]pentanes (BCPs) in particular, play an emerging role as saturated bioisosteres in pharmaceutical, agrochemical, and material chemistry. Taking advantage of strain release strategies, prior synthetic studies have f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::922e98ae4e07a8b7110e6f0e6854c14d
https://doi.org/10.26434/chemrxiv.13724827.v1
https://doi.org/10.26434/chemrxiv.13724827.v1
Autor:
Yangyang, Yang, Jet, Tsien, Ayala, Ben David, Jonathan M E, Hughes, Rohan R, Merchant, Tian, Qin
Publikováno v:
Journal of the American Chemical Society. 143(1)
Alkyl boronic acids and esters play an important role in the synthesis of C(sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d2fade1cc78acdd061f7ca800a9175d
https://pubmed.ncbi.nlm.nih.gov/33347297
https://pubmed.ncbi.nlm.nih.gov/33347297