Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M. E. Hickman"'
Autor:
Michael Themis, A Pavirani, S Jezzard, Robert D. Goldin, M. E. Hickman, Tristan R. McKay, Alan W. Cuthbert, Charles Coutelle, Ben Carpenter, L J MacVinish
Publikováno v:
Gene Therapy. 7:644-652
We have investigated the use of polycations to increase adenovirus-mediated expression of transgenic protein to the biliary epithelia with a view to gene therapy for hepatobiliary disease in CF. We have shown that adenovirus carrying the β-galactosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54abfde02556694c69d55f615ab0d6e0
https://doi.org/10.1038/sj.gt.3301144
https://doi.org/10.1038/sj.gt.3301144
Publikováno v:
British Journal of Pharmacology. 126:358-364
The mammalian colonic epithelium carries out a number of different transporting activities simultaneously, of which more than one is increased following activation with a single agonist. These separate activities can be quantified by solving a set of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caa893a5deb40bca6a4cff2759a26bc7
https://doi.org/10.1038/sj.bjp.0702290
https://doi.org/10.1038/sj.bjp.0702290
Publikováno v:
The Journal of Physiology. 510:237-247
The hyperpolarization of the apical membrane which results from the activation of basolateral K+ channels increases the driving force for the exit of Cl− ions in electrogenic secretory epithelia, as first proposed by Smith & Frizzel in 1984. In sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e1383769141873d17743f7d5b64b71
https://doi.org/10.1111/j.1469-7793.1998.237bz.x
https://doi.org/10.1111/j.1469-7793.1998.237bz.x
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 274:G1045-G1052
Mouse gallbladders (4 mm2) were investigated using the short-circuit current ( I sc) technique. Responses of 50 μA/cm2 were obtained in response to forskolin and agents that stimulated the adenylate cyclase system (IBMX and dibutyryl-cAMP). The calc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f28c8ca493aa8d14882d217fb5ddee
https://doi.org/10.1152/ajpgi.1998.274.6.g1045
https://doi.org/10.1152/ajpgi.1998.274.6.g1045
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1325:99-107
Iodide efflux, an index of anion permeability, has been monitored in cultured rat brain endothelial cells. Following hypotonicity-induced swelling, large, rapid increases in permeability occur, the extent of these increases depending on the degree of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ea3d0a164e2f47beea4e8e37946e06
https://doi.org/10.1016/s0005-2736(96)00249-0
https://doi.org/10.1016/s0005-2736(96)00249-0
Autor:
Peter R. Twentyman, Robert M. Henderson, Atticus H. Hainsworth, Margery A. Barrand, M. E. Hickman, Tracey Rowlands, Stephen B. Hladky
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 432:234-240
Anion transport in human multidrug-resistant large cell lung tumour cells (COR-L23/R) which overexpress the multidrug-resistance-associated protein (MRP) has been compared with that in cells of the parent line (COR-L23/P). Whole-cell patch-clamp reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaaf2a6289dc2ad837746ce69cb23b6
https://doi.org/10.1007/s004240050129
https://doi.org/10.1007/s004240050129
Autor:
William H. Colledge, Rosemary Ratcliff, Alan W. Cuthbert, L J MacVinish, M. E. Hickman, Mathew J. Evans
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 428:508-515
Electrogenic ion transport in the isolated colonic epithelium from normal and transgenic mice with cystic fibrosis (CF mice) has been investigated under short-circuit current (Isc) conditions. Normal tissues showed chloride secretion in response to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974ad631927cb3c2ca908f2d1626def1
https://doi.org/10.1007/bf00374572
https://doi.org/10.1007/bf00374572
Publikováno v:
British journal of pharmacology. 126(1)
1. The mammalian colonic epithelium carries out a number of different transporting activities simultaneously, of which more than one is increased following activation with a single agonist. These separate activities can be quantified by solving a set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbf2dd5a123d725d2ca0788c1b3c727d
https://pubmed.ncbi.nlm.nih.gov/10051156
https://pubmed.ncbi.nlm.nih.gov/10051156
Autor:
William H. Colledge, Alan W. Cuthbert, L. C. Martin, Christopher F. Higgins, L J MacVinish, C. M. Curtis, M. E. Hickman, M. J. Evans
Publikováno v:
Scopus-Elsevier
Gallbladders from cystic fibrosis (CF) mice ( Cftrtm1Cam and Cftrtm2Cam ) were examined with the short-circuit current technique. The tissues failed to show any electrogenic anion transport in response to forskolin (cAMP stimulus) but responded to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99f3261703aacbcb1d6afbc75a96762
https://pubmed.ncbi.nlm.nih.gov/9696705
https://pubmed.ncbi.nlm.nih.gov/9696705
Autor:
Alan W. Cuthbert, M. E. Hickman, Mathew J. Evans, William H. Colledge, P.W. Seale, P.P.A. Humphrey, Rosemary Ratcliff, L J MacVinish
Publikováno v:
Scopus-Elsevier
1. Guanylin, a 15 amino acid endogenous gut peptide, increased the short circuit current (SCC) in the epithelium of the mouse colon, but only when applied to the apical and not the basolateral surface. 2. By use of selective blockers of epithelial io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea3de09782293fe73a562c04d01a83e
https://pubmed.ncbi.nlm.nih.gov/7518307
https://pubmed.ncbi.nlm.nih.gov/7518307