Zobrazeno 1 - 10
of 548
pro vyhledávání: '"M. E. Duggan"'
Autor:
T. Prueksaritanont, C. Fernandez-Metzler, Y. Meng, A. Barrish, W. Halczenko, S. B. Rodan, J. H. Hutchinson, M. E. Duggan, J. H. Lin
Publikováno v:
Xenobiotica. 34:103-115
Autor:
T, Prueksaritanont, C, Fernandez-Metzler, Y, Meng, A, Barrish, W, Halczenko, S B, Rodan, J H, Hutchinson, M E, Duggan, J H, Lin
Publikováno v:
Xenobiotica. 34:103-115
1. The disposition of 3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl) propyl]-imidazolidin-1-yl]-3(S)-(6-methoxy-pyridin-3-yl)propionic acid (compound A), a potent and selective alpha(v)beta(3) antagonist, was characterized in several anima
Autor:
Zhen Yang, Elias A. Couladouros, Kyriacos C. Nicolaou, X.‐Y. Xiao, M. E. Duggan, J. Tiebes, Emmanuel A. Theodorakis, F. Sato, M. Sato, T. Bleckman, Floris P. J. T. Rutjes, C.-K. Hwang, H.‐M. He, Jongheon Shin
Publikováno v:
Journal of the American Chemical Society. 117:10239-10251
The second generation strategy for the total synthesis of brevetoxin B (1) is presented. According to this •strategy, the heptacyclic (ABCDEFG) phosphonium iodide 4 and the tricyclic (UK) aldehyde 3 were defined as the precursors for the brevetoxin
Autor:
M E, Duggan, A M, Naylor-Olsen, J J, Perkins, P S, Anderson, C T, Chang, J J, Cook, R J, Gould, N C, Ihle, G D, Hartman, J J, Lynch
Publikováno v:
Journal of Medicinal Chemistry. 38:3332-3341
The design, synthesis, and pharmacological evaluation of L-734,217, a potent, low-molecular weight, orally active fibrinogen receptor antagonist, is reported. A strategy for producing low-molecular weight inhibitors from the peptide c-[(Ac)CRGDC] A,
Autor:
F. P. J. T. Rutjes, R. A. Awartani, Emmanuel A. Theodorakis, Yoshito Abe, K. B. Reddy, Scott R. Conley, S. A. Defrees, D. A. Nugiel, M. E. Duggan, C.-K. Hwang, Kyriacos C. Nicolaou, D. R. Reddy
Publikováno v:
ChemInform. 27
Autor:
M. E. Duggan, X.‐Y. Xiao, Emmanuel A. Theodorakis, C.-K. Hwang, F. P. J. T. Rutjes, J. Tiebes, Kyriacos C. Nicolaou, T. Bleckman, Elias A. Couladouros, M. Sato, Jongheon Shin, H.‐M. He, F. Sato, Zhen Yang
Publikováno v:
ChemInform. 27
Publikováno v:
Organicbiomolecular chemistry. 3(12)
The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride has been carried out and compared
Publikováno v:
Organicbiomolecular chemistry. 3(12)
A new method for gamma-acylation of protected glutamic acids, involving intramolecular rearrangement of an acyl urethane, has been devised to prepare the protected gamma-carboxyglutamates 7, 9 and 11 and the protected 4-acylglutamates 15 and 22 from
Autor:
Wu K; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China., Kang K; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Liu D; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Zhang C; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Wang X; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Zhang M; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Li Q; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.; Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Apr 11; Vol. 30 (21), pp. e202400234. Date of Electronic Publication: 2024 Feb 20.
Autor:
G D, Hartman, M E, Duggan
Publikováno v:
Expert opinion on investigational drugs. 9(6)
The alpha(v)beta(3) integrin is a non-covalent, heterodimeric, cell-surface protein that is expressed with varying density on numerous cell types, including osteoclasts, vascular smooth muscle cells, endothelial cells and a variety of tumour cells. F