Výsledky vyhledávání - "M. E. Bollard"

Metabonomics: its potential as a tool in toxicology for safety assessment and data integration

Autor: M E Bollard, J L Griffin

Publikováno v: Current drug metabolism. 5(5)

The functional genomic techniques of transcriptomics and proteomics promise unparalleled global information during the drug development process. However, if these technologies are used in isolation the large multivariate data sets produced are often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542579c14c184d5a40768756cec4fb7d
https://pubmed.ncbi.nlm.nih.gov/15544433

Zobrazit plný text záznamu

High-resolution (1)H and (1)H-(13)C magic angle spinning NMR spectroscopy of rat liver

Autor: M E, Bollard, S, Garrod, E, Holmes, J C, Lindon, E, Humpfer, M, Spraul, J K, Nicholson

Publikováno v: Magnetic resonance in medicine. 44(2)

High-resolution magic angle spinning (MAS) (1)H NMR spectra of small samples (ca. 8 mg) of intact rat liver are reported for the first time. One dimensional spectra reveal a number of large well-resolved NMR signals mainly from low to medium molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01b41aa5e835c0ce355372546561bacc
https://pubmed.ncbi.nlm.nih.gov/10918318

Zobrazit plný text záznamu

1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat

Autor: John C. Lindon, M. E. Bollard, Ian D. Wilson, Elaine Holmes, C. A. Blackledge, Jeremy K. Nicholson

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 26(3)

1. 1H and 19F-nmr spectroscopy was used to investigate quantitatively the urinary excretion of the metabolites of 15 substituted phenols in the rat. The compounds studied were: 2-, 3-, and 4-fluorophenols; 2-, 3-, and 4-trifluoromethylphenol; 2,4-, 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac5d0bfc0e3ba2fa0fed2d7b28fd882
https://pubmed.ncbi.nlm.nih.gov/8730918

Zobrazit plný text záznamu

Prediction of urinary sulphate and glucuronide conjugate excretion for substituted phenols in the rat using quantitative structure-metabolism relationships

Autor: Elaine Holmes, Ian D. Wilson, C. R. Beddell, C. A. Blackledge, Jeremy K. Nicholson, M. E. Bollard, B. C. Sweatman, John C. Lindon

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 25(12)

1. The quantitative urinary excretion of the sulphate and glucuronide metabolites of 15 substituted phenols dosed to rat has been determined using high resolution 19F-nmr spectroscopy. 2. The urinary metabolic fate of each of the compounds was relate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba7698c48b26bba1be24ac326b800e0
https://pubmed.ncbi.nlm.nih.gov/8719903

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání