BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients

Autor: Hanne Meijers-Heijboer, Egbert Bakker, M.J.L. Ligtenberg, Anne Petrij-Bosch, Tamara Peelen, M. Drusedau, Cees J. Cornelisse, R. Olmer, Peter Devilee, S. Hageman, Hans F. A. Vasen, L.J. van 't Veer, Jan G. M. Klijn, G.J.B. van Ommen, Frans B. L. Hogervorst, Peer Arts, M. van Vliet, R. van Eijk

Publikováno v: Nature Genetics, 17, 341-345
Nature Genetics, 17, 3, pp. 341-345
Nature Genetics, 17, pp. 341-345
Nature genetics, 17(3), 341-345. Nature Publishing Group

To date, more than 300 distinct small deletions, insertions and point mutations, mostly leading to premature termination of translation, have been reported in the breast/ovarian-cancer susceptibility gene BRCA1. The elevated frequencies of some mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f5e60aebf7c879ed17cbc5d09d4da5
https://doi.org/10.1038/ng1197-341