Zobrazeno 1 - 10
of 236
pro vyhledávání: '"M. Dreyfuss"'
Autor:
J. Shapiro, B. Getz, S.B. Cohen, Y. Jenudi, D. Underberger, M. Dreyfuss, T.I. Ber, S. Steinberg-Koch, A. Ben-Tov, Y. Shoenfeld, O. Shovman
Publikováno v:
Journal of Translational Autoimmunity, Vol 7, Iss , Pp 100207- (2023)
Background: Psoriatic arthritis (PsA), an immune-mediated chronic inflammatory skin and joint disease, affects approximately 0.27% of the adult population, and 20% of patients with psoriasis. Up to 10% of psoriasis patients are estimated for having u
Externí odkaz:
https://doaj.org/article/694bd3a2140b4613bcf909228ac3fac7
Autor:
Jonathan M. Dreyfuss, Vera Djordjilović, Hui Pan, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Matthias Blüher, Yu-Hua Tseng, Matthew D. Lynes
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Activating brown adipose tissue (BAT) improves systemic metabolism, making it a promising target for metabolic syndrome. BAT is activated by 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), which we previously identified to be inversely
Externí odkaz:
https://doaj.org/article/afea66cd67a749dc88a7aa390e8ba4af
Autor:
Pattarawan Pattamaprapanont, Eileen M. Cooney, Tara L. MacDonald, Joao A. Paulo, Hui Pan, Jonathan M. Dreyfuss, Sarah J. Lessard
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100159- (2024)
Skeletal muscle has a unique ability to remodel in response to stimuli such as contraction and aerobic exercise training. Phenotypic changes in muscle that occur with training such as a switch to a more oxidative fiber type, and increased capillary d
Externí odkaz:
https://doaj.org/article/37f49428b788458294966f8f3bd9d9c4
Autor:
Jonathan M. Dreyfuss, Yixing Yuchi, Xuehong Dong, Vissarion Efthymiou, Hui Pan, Donald C. Simonson, Ashley Vernon, Florencia Halperin, Pratik Aryal, Anish Konkar, Yinong Sebastian, Brandon W. Higgs, Joseph Grimsby, Cristina M. Rondinone, Simon Kasif, Barbara B. Kahn, Kathleen Foster, Randy Seeley, Allison Goldfine, Vera Djordjilović, Mary Elizabeth Patti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Factors underlying the effects of gastric bypass surgery on glucose homeostasis are incompletely understood. Here the authors developed and applied high-throughput mediation analysis to identify proteome/metabolome mediators of improved glucose homeo
Externí odkaz:
https://doaj.org/article/77b147ec15344c3cb4b79626a96517bd
Autor:
Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F. De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M. Dreyfuss, A.M. James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111436- (2022)
Summary: Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by S961, a pharmacological
Externí odkaz:
https://doaj.org/article/3143a9f198114e48a593ab4fa7acda69
Autor:
Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNA-seq). We introduce s
Externí odkaz:
https://doaj.org/article/0a2587f053b54f06ac12b83d0434a5c0
Autor:
Gourav Bhardwaj, Christie M. Penniman, Katherine Klaus, Eric T. Weatherford, Hui Pan, Jonathan M. Dreyfuss, K. Sreekumaran Nair, C. Ronald Kahn, Brian T. O’Neill
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene expression. Here, we show that while muscle-speci
Externí odkaz:
https://doaj.org/article/12e0ed4261ec4c6fa29831c2ccb2b2f1
Autor:
Mari Sato, Tadataka Tsuji, Kunyan Yang, Xiaozhi Ren, Jonathan M Dreyfuss, Tian Lian Huang, Chih-Hao Wang, Farnaz Shamsi, Luiz O Leiria, Matthew D Lynes, King-Wai Yau, Yu-Hua Tseng
Publikováno v:
PLoS Biology, Vol 18, Iss 2, p e3000630 (2020)
Opsin3 (Opn3) is a transmembrane heptahelical G protein-coupled receptor (GPCR) with the potential to produce a nonvisual photoreceptive effect. Interestingly, anatomical profiling of GPCRs reveals that Opn3 mRNA is highly expressed in adipose tissue
Externí odkaz:
https://doaj.org/article/796dbcea1d5e487694fa40a3e9fa5947
Autor:
Shiho Fujisaka, Julian Avila-Pacheco, Marion Soto, Aleksandar Kostic, Jonathan M. Dreyfuss, Hui Pan, Siegfried Ussar, Emrah Altindis, Ning Li, Lynn Bry, Clary B. Clish, C. Ronald Kahn
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 3072-3086 (2018)
Summary: Diet, genetics, and the gut microbiome are determinants of metabolic status, in part through production of metabolites by the gut microbiota. To understand the mechanisms linking these factors, we performed LC-MS-based metabolomic analysis o
Externí odkaz:
https://doaj.org/article/60ccf368e5734442a9a4679d88badbcc
Autor:
Alfred K. Ramirez, Matthew D. Lynes, Farnaz Shamsi, Ruidan Xue, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif, Jonathan M. Dreyfuss
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3040-3048 (2017)
White adipocytes are specialized for energy storage, whereas brown adipocytes are specialized for energy expenditure. Explicating this difference can help identify therapeutic targets for obesity. A common tool to assess metabolic differences between
Externí odkaz:
https://doaj.org/article/eae133fb784c475695891c7ed8339569